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RISS 인기검색어
- 검색키워드
- 저자 : Pegah Khazaei (검색결과 3 건)
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Pegah Khazaei,Mehdi Mohammadimehr 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.76 No.1
In this paper, the deflection and buckling analyses of porous nano-composite piezoelectric plate reinforced by carbon nanotube (CNT) are studied. The equations of equilibrium using energy method are derived from principle of minimum total potential energy. In the research, the non-local strain gradient theory is employed to consider size dependent effect for porous nanocomposite piezoelectric plate. The effects of material length scale parameter, Eringen’s nonlocal parameter, porosity coefficient and aspect ratio on the deflection and critical buckling load are investigated. The results indicate that the effect of porosity coefficient on the increase of the deflection and critical buckling load is greatly higher than the other parameters effect, and size effect including nonlocal parameter and the material length scale parameter have a lower effect on the deflection increase with respect to the porosity coefficient, respectively and vice versa for critical buckling load. Porous nanocomposites are used in various engineering fields such as aerospace, medical industries and water refinery.
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Pegah Khazaei,Mehdi Mohammadimehr 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.26 No.1
This paper investigates the size dependent effect on the vibration analysis of a porous nanocomposite viscoelastic plate reinforced by functionally graded-single walled carbon nanotubes (FG-SWCNTs) by considering nonlocal strain gradient theory. Therefore, using energy method and Hamilton’s principle, the equations of motion are derived. In this article, the effects of nonlocal parameter, aspect ratio, strain gradient parameter, volume fraction of carbon nanotubes (CNTs), damping coefficient, porosity coefficient, and temperature change on the natural frequency are perused. The innovation of this paper is to compare the effectiveness of each mentioned parameters individually on the free vibrations of this plate and to represent the appropriate value for each parameter to achieve an ideal nanocomposite plate that minimizes vibration. The results are verified with those referenced in the paper. The results illustrate that the effect of damping coefficient on the increase of natural frequency is significantly higher than the other parameters effect, and the effects of the strain gradient parameter and nonlocal parameter on the natural frequency increase are less than damping coefficient effect, respectively. Furthermore, the results indicate that the natural frequency decreases with a rise in the nonlocal parameter, aspect ratio and temperature change. Also, the natural frequency increases with a rise in the strain gradient parameter and CNTs volume fraction. This study can be used for optimizing the industrial and medical designs, such as automotive industry, aerospace engineering and water purification system, by considering ideal properties for the nanocomposite plate.
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Antiproliferatory Effects of Crab Shell Extract on Breast Cancer Cell Line (MCF7)
Leila Rezakhani,Zahra Rashidi,Pegah Mirzapur,Mozafar Khazaei 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3
Purpose: Breast cancer is the most common type of cancer inwomen. Despite various pharmacological developments, theidentification of new therapies is still required for treating breastcancer. Crab is often recommended as a traditional medicine forcancer. This study aimed to determine the in vitro effect of a hydroalcoholiccrab shell extract on a breast cancer cell line. Methods:In this experimental study, MCF7 breast cancer cell line wasused. Crab shell was powdered and a hydroalcoholic (70° ethanol)extract was prepared. Five concentrations (100, 200, 400,800, and 1,000 μg/mL) were added to the cells for three periods,24, 48, and 72 hours. The viability of the cells were evaluatedusing trypan blue and 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assays. Cell apoptosis was determined usingthe terminal deoxynucleotidyl transferase dUTP nick end labelingmethod. Nitric oxide (NO) level was assessed using theGriess method. Data were analyzed using analysis of variance,and p<0.05 was considered significant. Results: Cell viabilitydecreased depending on dose and time, and was significantlydifferent in the groups that were treated with 400, 800, and 1,000μg/mL doses compared to that in the control group (p<0.001). Increasing the dose significantly increased apoptosis (p<0.001). NO secretion from MCF7 cells significantly decreased in responseto different concentrations of the extract in a dose- andtime-dependent manner (p<0.050). Conclusion: The crab shellextract inhibited the proliferation of MCF7 cells by increasingapoptosis and decreasing NO production.
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