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Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts
Kim, Byung-Mi,Chen, Mei-Huei,Chen, Pau-Chung,Park, Hyesook,Ha, Mina,Kim, Yangho,Hong, Yun-Chul,Kim, Young Ju,Ha, Eun-Hee Elsevier 2017 Science of the Total Environment Vol.605 No.-
<P><B>Abstract</B></P> <P>Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level>25th percentile) was detected (maternal blood: β=−0.056; 95% CI, −0.100 to −0.013, cord blood: β=−0.075; 95% CI, −0.121 to −0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β=−0.177, <I>P</I> =0.01 in MOCEH, β=−0.204, <I>P</I> =0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The association between Hg from fish consumption and birth weight is unclear. </LI> <LI> Path analysis showed a direct path from fish consumption to cord blood Hg. </LI> <LI> Cord blood Hg level was directly related to lower birth weight. </LI> <LI> Decreased between birth weight was indirectly related to fish consumption. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
The National Health Insurance Research Database (NHIRD)
Liang-Yu Lin,Charlotte Warren-Gash,Liam Smeeth,Pau-Chung Chen 한국역학회 2018 Epidemiology and Health Vol.40 No.-
Electronic health records (EHRs) can provide researchers with extraordinary opportunities for population based research. The National Health Insurance system of Taiwan was established in 1995 and covers more than 99.6% of the Taiwanese population; this system’s claims data are released as the National Health Insurance Research Database (NHIRD). All data from primary outpatient departments and inpatient hospital care settings are included in this database. After a change and update in 2016, the NHIRD is maintained and regulated by the Data Science Centre of the Ministry of Health and Welfare of Taiwan. Datasets for approved research are released in three forms: sampling datasets comprising two million subjects, disease-specific datasets, and full population datasets. These datasets are de-identified and contain basic demographic information, disease diagnoses, prescriptions, operations, and investigations. Data can be linked to governmental surveys or other research datasets. While only a small number of validation studies with small sample sizes have been undertaken, they generally report positive predictive values of over 70% across different diagnoses. Currently, patients cannot opt out of inclusion in the database, though this requirement is under review. In conclusion, the NHIRD is a large, powerful data source for biomedical research.