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RISS 인기검색어
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- 저자 : Partha MANDAL (검색결과 8 건)
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Partha Mandal,Barrett P. O’Donnell,Eric Reuben Smith,Osamah Al-Bayati,Adam Khalil,Serena Jen,Mario Vela,Jorge Lopera 소화기인터벤션의학회 2022 Gastrointestinal Intervention Vol.11 No.1
Background: This study investigated the incidence and clinical outcomes of portal and hepatic vein thrombosis (VT) on imaging after transjugular intrahepatic portosystemic shunt (TIPS). Methods: A retrospective review of records at a single liver transplant center between 2010 and 2018 revealed 423 patients who underwent TIPS. Contrast-enhanced computed tomography and magnetic resonance images within 1 year post-TIPS were available for 138 patients and compared to assess the imaging findings of VT and liver infarction. The associations of VT with overall survival, patient characteristics, stent size, pre- and post- TIPS Model for End-Stage Liver Disease (MELD) scores, and post-TIPS hepatic encephalopathy at 90 days were analyzed. Results: The prevalence of VT on imaging within 1 year was 63.0% (n = 87). VT within the right portal vein was more common: 41 cases were in the right portal vein, 25 in the posterior portal vein, and two in the anterior right portal vein. Ten patients had VT in the left portal vein. Four had VT in the main portal vein (MPV), and one had shunt thrombosis extending into the superior mesenteric vein. Hepatic VT was seen in the right hepatic vein in 17 patients and in the middle hepatic vein in six patients. VT was associated with liver infarction (n = 9, P = 0.018). There was no relationship between VT and sex, age, cirrhosis etiology, indication for TIPS, stent size, or hepatic encephalopathy at 90 days. VT in the MPV had poorer survival (P < 0.001). Older age (P = 0.028) and higher pre-TIPS MELD score (P = 0.049) were poor prognostic factors. VT was not treated. Conclusion: Portal and hepatic VTs were common imaging findings after TIPS without worsened clinical outcomes unless VT involved the MPV. VT may cause liver infarction, but infarcts were not independently associated with poorer survival.
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Partha Mandal,Barrett P. O’Donnell,Eric Reuben Smith,Osamah Al-Bayati,Adam Khalil,Serena Jen,Mario Vela,Jorge Lopera 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.1
Background: This study investigated the incidence and clinical outcomes of portal and hepatic vein thrombosis (VT) on imaging after transjugular intrahepatic portosystemic shunt (TIPS). Methods: A retrospective review of records at a single liver transplant center between 2010 and 2018 revealed 423 patients who underwent TIPS. Contrast-enhanced computed tomography and magnetic resonance images within 1 year post-TIPS were available for 138 patients and compared to assess the imaging findings of VT and liver infarction. The associations of VT with overall survival, patient characteristics, stent size, pre- and post- TIPS Model for End-Stage Liver Disease (MELD) scores, and post-TIPS hepatic encephalopathy at 90 days were analyzed. Results: The prevalence of VT on imaging within 1 year was 63.0% (n = 87). VT within the right portal vein was more common: 41 cases were in the right portal vein, 25 in the posterior portal vein, and two in the anterior right portal vein. Ten patients had VT in the left portal vein. Four had VT in the main portal vein (MPV), and one had shunt thrombosis extending into the superior mesenteric vein. Hepatic VT was seen in the right hepatic vein in 17 patients and in the middle hepatic vein in six patients. VT was associated with liver infarction (n = 9, P = 0.018). There was no relationship between VT and sex, age, cirrhosis etiology, indication for TIPS, stent size, or hepatic encephalopathy at 90 days. VT in the MPV had poorer survival (P < 0.001). Older age (P = 0.028) and higher pre-TIPS MELD score (P = 0.049) were poor prognostic factors. VT was not treated. Conclusion: Portal and hepatic VTs were common imaging findings after TIPS without worsened clinical outcomes unless VT involved the MPV. VT may cause liver infarction, but infarcts were not independently associated with poorer survival.
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Ghosh Debasis,Mandal Mrinal,Karmakar Manas,Mandal Dayamoy,Modak Partha,Ghosh Biswajit,Mandi Susanta,Haque Sk. Mafizul 대한공간정보학회 2021 Spatial Information Research Vol.29 No.5
Malnutrition is a global phenomenon in general and India is no exception. Present study was conducted to determine the prevalence of undernutrition among the Santal children of Ajodhya Gram Panchayat of Purulia district of West Bengal, India. Here, quality of life of the households of the studied research participants is also investigated to understand the role of quality of life in the prevalence of undernutrition. A total number of 307 children aged in between 5–10 years were evaluated using the standard anthropometric techniques, such as height-forage, weight-for-age and body mass index for-age to determine the prevalence of stunting, wasting and underweight conditions of the Santal tribal children. The nutritional status index of children and the quality of life index of those children’s households have also been calculated to perceive the relation between these two indices. A cluster analysis has also been performed to see the similarity in terms of nutritional level among the children across the mouzas of Ajodhya Gram Panchayat. The prevalence of stunting, wasting and underweight among the children is found to be 27.69%, 36.81% and 44.63% respectively. The overall prevalence of undernutrition is recorded 58.31%. The nutritional status index is calculated to be 0.488 (moderate) for children, while the quality of life index for households is computed as 0.199 (very poor). The study reveals the occurrence of undernutrition among children is closely associated with poor quality of life of households of Ajodhya. The chi-square tests indicate that no statistically significant variation (p\0.05) in the prevalence of undernutrition in between male and female children, and among the different age groups is observed.
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Ghosh, Ishita,Ghosh, Pramit,Bharti, Alok Chandra,Mandal, Ranajit,Biswas, Jaydip,Basu, Partha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Background: Human papillomavirus (HPV) is a very common sexually transmitted disease affecting both men and women and is responsible for different ano-genital cancers in either sex. Co-existing sexually transmitted infections (STI) including HIV have been considered as important co-factors for carcinogenesis induced by HPV. The purpose of this study was to determine the prevalence of any HPV, HPV 16 and HPV 18 and also concomitant STIs among female sex workers (FSW), men having sex with men (MSM) and injectable drug users (IDU). Material and Method: This cross-sectional study was conducted among 45 FSWs, 26 MSMs and 58 IDUs who attended the STI or de-addiction clinics. Genital scrape samples collected from glans penis and coronal sulcus in males and cervical squamo-columnar junction in females were tested for HPV DNA by PCR using HPV L1 consensus primer. Type specific PCR to detect HPV 16 and 18 was done on the samples positive on consensus PCR. All participants were tested for associated STIs including HIV and hepatitis B and cervical cytology was done on all females. Results: Among the FSWs, HPV was detected in 73.3% and HPV 16 and 18 was detected in 25.7%. Though the HPV prevalence was similarly high among MSMs (69.2%) and IDUs (72.4%), the prevalence of HPV 16 and 18 was much lower in these groups compared to the FSWs. Prevalence of cervico-vaginal infection with Trichomonas vaginalis and syphilis was significantly higher in the HPV positive women compared to the HPV negative women. There was no statistically significant difference in the prevalence of other STIs among HPV positive and negative women and men. Conclusion: HPV infection is highly prevalent among FSW, MSM and IDUs. Trichomonas vaginalis infection is more frequent in HPV positive women.
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Lipika Rani Bairi,Darothi Bairagi,Partha Duley,Sumantra Mandal 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.7
The current study investigates the effect of long-term immersion on the corrosion response and the consequent passive filmformation process of lean duplex stainless steel 2101 in 3.5 wt% NaCl solution. The corrosion behavior of the alloy has beenmonitored through long term immersion tests at different time intervals, viz. 0, 3, 5, 10, 20, 40, and 70 days. The electrochemicaltests, such as potentiodynamic polarization and electrochemical impedance spectroscopy, have been performedafter each immersion period to understand the change in corrosion rate and passivation behaviour, respectively, with respectto immersion duration. With the increase in immersion duration, the pitting potential (Epit) gradually shifts towards a noblerdirection with a simultaneous reduction in corrosion rate (rcorr). This has been attributed to the gradual increase in the thicknessof the passive film with the increase in duration of immersion, as revealed through the EIS analysis. The passive filmis found to become nearly stable after 40 days of immersion of the specimen in 3.5 wt% NaCl solution. Interestingly, thethickness and stability of the passive film obtained after 40 days of immersion in 3.5 wt% NaCl solution are comparable tothe passive film that is formed in mildly passivating media, namely borate buffer solution. An investigation of post immersionsurface morphology has also confirmed the gradual improvement in the uniformity and compactness of the oxide-richpassive layer with increase in immersion period, which eventually led to improved corrosion resistance of the alloy in thesaline environment.
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Gopal, Velmani,AL Rashid, Mohammad Harun,Majumder, Sayani,Maiti, Partha Pratim,Mandal, Subhash C KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.2
Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 naphthoquinone and its metabolite THN by using the molecular docking program AutoDock 4. Methods: The 3D structure of ligands such as hydrogen peroxide ($H_2O_2$), nitric oxide synthase (NOS), catalase (CAT), glutathione (GSH), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PDH) and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) were drawn using hyperchem drawing tools and minimizing the energy of all pdb files with the help of hyperchem by $MM^+$ followed by a semi-empirical (PM3) method. The docking process was studied with ligand molecules to identify suitable dockings at protein binding sites through annealing and genetic simulation algorithms. The program auto dock tools (ADT) was released as an extension suite to the python molecular viewer used to prepare proteins and ligands. Grids centered on active sites were obtained with spacings of $54{\times}55{\times}56$, and a grid spacing of 0.503 was calculated. Comparisons of Global and Local Search Methods in Drug Docking were adopted to determine parameters; a maximum number of 250,000 energy evaluations, a maximum number of generations of 27,000, and mutation and crossover rates of 0.02 and 0.8 were used. The number of docking runs was set to 10. Results: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids. Conclusion: Naphthoquinone derivatives of lawsone, which can be metabolized into THN by a catalyst DTD, were examined. Lawsone and THN were found to be identically potent molecules for their affinities for selected proteins.
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Velmani Gopal,Mohammad Harun AL Rashid,Sayani Majumder,Partha Pratim Maiti,Subhash C. Mandal 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.2
Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 naphthoquinone and its metabolite THN by using the molecular docking program AutoDock 4. Methods: The 3D structure of ligands such as hydrogen peroxide (H2O2), nitric oxide synthase (NOS), catalase (CAT), glutathione (GSH), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PDH) and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) were drawn using hyperchem drawing tools and minimizing the energy of all pdb files with the help of hyperchem by MM+ followed by a semi-empirical (PM3) method. The docking process was studied with ligand molecules to identify suitable dockings at protein binding sites through annealing and genetic simulation algorithms. The program auto dock tools (ADT) was released as an extension suite to the python molecular viewer used to prepare proteins and ligands. Grids centered on active sites were obtained with spacings of 54 × 55 × 56, and a grid spacing of 0.503 was calculated. Comparisons of Global and Local Search Methods in Drug Docking were adopted to determine parameters; a maximum number of 250,000 energy evaluations, a maximum number of generations of 27,000, and mutation and crossover rates of 0.02 and 0.8 were used. The number of docking runs was set to 10. Results: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids. Conclusion: Naphthoquinone derivatives of lawsone, which can be metabolized into THN by a catalyst DTD, were examined. Lawsone and THN were found to be identically potent molecules for their affinities for selected proteins.
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