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Park, Pil-Gu,Cho, Min-Hee,Rhie, Gi-eun,Jeong, Haeseul,Youn, Hyewon,Hong, Kee-Jong The Korean Vaccine Society 2012 Clinical and Experimental Vaccine Research Vol.1 No.1
<P><B>Purpose</B></P><P>In vaccine efficacy evaluation, visualization of pathogens in whole organism at each time point would be able to reduce the consuming animals and provide the <I>in vivo</I> information within consistent background with identical organism.</P><P><B>Materials and Methods</B></P><P>Using IVIS spectrum whole live-animal imaging system, fluorescent intensity was optimized and visualized proportionately by concentrating <I>Escherichia coli</I> MC1061 strain which expresses GFP (<I>E. coli</I>-GFP) in BALB/C mice after injection.</P><P><B>Results</B></P><P>Local distribution of disseminated <I>E. coli</I>-GFP was traced in each organ by fluorescence. Detached organ showed more obvious fluorescent signal, and intestine showed strongest fluorescent signal.</P><P><B>Conclusion</B></P><P>This <I>in vivo</I> imaging method using GFP-tagged pathogen strain suggest quantified infected pathogens by fluorescence intensity in whole animals can provide the information about the localization and distribution after infection.</P>
Current development of therapeutic vaccines for the treatment of chronic infectious diseases
Park Pil-Gu,Fatima Munazza,An Timothy,Moon Ye-Eun,Woo Seungkyun,Youn Hyewon,Hong Kee-Jong 대한백신학회 2024 Clinical and Experimental Vaccine Research Vol.13 No.1
Chronic infectious diseases refer to diseases that require a long period of time from onset to cure or death, the use of therapeutic vaccines has recently emerged to eradicate diseases. Currently, clinical research is underway to develop therapeutic vaccines for chronic infectious diseases based on various vaccine formulations, and the recent success of the messenger RNA vaccine platform and efforts to apply it to therapeutic vaccines are having a positive impact on conquering chronic infectious diseases. However, since research on the development of therapeutic vaccines is still relatively lacking compared to prophylactic vaccines, there is a need to focus more on the development of therapeutic vaccines to overcome threats to human health caused by chronic infectious diseases. In order to accelerate the development of therapeutic vaccines for chronic infectious diseases in the future, it is necessary to establish a clear concept of therapeutic vaccines suitable for the characteristics of each chronic infectious disease, as well as standardize vaccine effectiveness evaluation methods, secure standards/reference materials, and simplify the vaccine approval procedure.
Web-Based KNHANES System in Cloud Computing
Park, Mi-Yeon,Park, Pil-Sook,Kim, Guk-Boh,Park, Jin-Yong,Jeong, Gu-Beom Korea Multimedia Society 2014 멀티미디어학회논문지 Vol.17 No.3
Cloud computing is an internet-based technology, providing services to the virtualized IT environment, and allowing users to add or remove resources of hardware or software at their discretion. Since Cloud computing can construct virtually integrated environments out of multiple local computing environments, various information services can be provided by it. In addition, state organizations also strive to build the cloud computing environments due to the benefits of reduced costs to introduce the system and of reduced time to build and provide the IT services. This study suggests a web-based cloud computing system for the computing environments, to be applied for the Korean National Health and Nutrition Examination Survey (KNHANES) by the Ministry of Health and Welfare, Republic of Korea.
만성질환 이환율을 이용한 여자노인의 체질량지수에 대한아시아-태평양지역 기준과 Entropy모델 기준 비교
정구범(Gu Beom Jeong),박진용(Jin Yong Park),권세영(Se Young Kwon),박경옥(Kyung Ok Park),박필숙(Pil Sook Park),박미연(Mi Yeon Park) 대한지역사회영양학회 2014 대한지역사회영양학회지 Vol.19 No.5
This study was conducted to propose the need of re-establishing the criteriaof the body weight classification in the elderly. We compared the Asia-Pacific RegionCriteria (APR-C) with Entropy Model Criteria (ENT-C) using Morbidity rate of chronicdiseases which correlates significantly with Body Mass Index (BMI). Methods: Subjects were 886 elderly female participating in the 2007-2009 KoreaNational Health and Nutrition Examination Survey (KNHANES). We compared APRCwith those of ENT-C using Receiver Operating Characteristics (ROC) curve andlogistic regression analysis. Results: In the case of the morbidity of hypertension, the results were as follows:Where it was in the T-off point of APR-C, sensitivity was 67.5%, specificity was43.1%, and Youden``s index was 10.6. While in the cut-off point of ENT-C, it was56.7%, 56.6%, and 13.3 respectively. In the case of the morbidity of diabetes, theresults were as follows: In the cut-off point of APR-C, Youden’s index was 14.2. Whilein the cut-off point of ENT-C, it was 17.2 respectively. The Area Under the ROCCurve (AUC) of the subjects who had more than 2 diseases among hypertension,diabetes, and dyslipidemia was 0.615 (95% CI: 0.578-0.652). Compared to the normalgroup, the odds ratio of the hypertension group which will belong to the overweight orobesity was 1.79 (95% CI: 1.30-2.47) in the APR-C, and 2.04 (95% CI: 1.49-2.80) inthe ENT-C (p < 0.001). Conclusions: We conclude that the optimal cut-off point of BMI to distinguish betweennormal weight and overweight was 24 kg/m2 (ENT-C) rather than 23 kg/m2 (APR-C).
포스터 전시 : 상부위장관 ; 식도 이완 불능증 환자에서 발생한 조기 위암 1예
박정필 ( Park Jeong Pil ),김신 ( Kim Sin ),김유리 ( Kim Yu Li ),임대관 ( Im Dae Gwan ),김지연 ( Kim Ji Yeon ),박무인 ( Park Mu In ),박선자 ( Park Seon Ja ),박요한 ( Park Yo Han ),구자영 ( Gu Ja Yeong ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<증례>심한 심와부 동통으로 상부 위장관 내시경을 시행한 57세 여자 환자에서 식도에 잔류된 음식물과 함께 상부 위체부의 후벽에 1.5㎝ 크기의 불규칙한 미란 및 궤양 반흔이 보여 조직 생검을 시행하였으며 그 결과 인환 세포암으로 나왔다. 식도 내압 검사상 식도 무연 운동을 보였는데 20년전 식도 이완 불능증으로 진단 받은 후 간헐적으로 연하곤란을 느꼈지만 특별한 치료를 받지 않고 지냈다고 한다. 과거력상 자궁암으로 자궁 전적출술을 받았으며 갑상선 기능