http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
홍용근,양민석,박윤배 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
We previously reported that the exogenous administration of cumambrin A, a sesquiterpene lactone from the dried flowers of Chrysanthemum boreale Makino has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In the present study, we further investigated the effect of cumambrin A on the relaxation of phenylephrine-induced precontracted rat aortic artery rings. The potency of cumambrin A was then compared to verapamil, a well known Ca^(2+)-channel blocker. The results demonstrate that the isolated rat aortic arteries are relaxed to basal tension at a concentration of 5X10^(-5)M cumambrin A treatment. The results also show that the phenylephrine-induced contraction is inhibited by a pretreatment of cumambrin A. Co-treatment of cumambrin A and verapamil showed a strong synergetic effect on the relaxation of rat aortic artery rings. Thus, these data demonstrate that cumambrin A is a potent relaxant of rat aortic smooth muscle and suggest that cumambrin A modulates intracellular or extracellular Ca^(2+) mobilization.
Pak Yun-Suk,Ro Young Sun,Kim Se-Hyung,Han So-Hyun,Ko Sung-keun,Kim Taehui,Kwak Young Ho,Heo Tag,Moon Sungwoo 대한의학회 2021 Journal of Korean medical science Vol.36 No.16
Background: The purpose of this study was to review the nationwide emergency care-related health policies during the coronavirus disease 2019 (COVID-19) pandemic disaster in Korea and to analyze the effects of the policies on the safety of patients who visit emergency departments (EDs) during this period. Methods: This study is a quasi-experiment study. The study population was patients who visited all 402 EDs in Korea between December 31, 2019 and May 13, 2020, using the National Emergency Department Information System (NEDIS) database. The study period was classified into 5 phases according to the level of national crisis warning of infectious disease and the implementation of emergency care-related health policies, and all study phases were 27 days. The primary outcome was in-hospital mortality, and the secondary outcome was length of stay (LOS) in the ED during the COVID-19 outbreak. Results: The number of ED visits during the study period was 2,636,341, and the in-hospital mortality rate was 1.4%. The number of ED visits decreased from 803,160 in phase 1 to 496,619 in phase 5 during the study period. For in-hospital mortality, the adjusted odds ratio (OR) (95% confidence interval) was 0.77 (0.74–0.79) in phase 5 compared to phase 3. Additionally, by subgroup, the ORs were 0.69 (0.57–0.83) for the patients with acute myocardial infarction and 0.76 (0.67–0.87) for severe trauma in phase 5 compared to phase 3. The ED LOS increased while the number of ED visits decreased as the COVID-19 pandemic progressed, and the ED LOS declined after policy implementation (beta coefficient: −5.3 [−6.5 to −4.2] minutes in phase 5 compared to phase 3). Conclusion: Implementing appropriate emergency care policies in the COVID-19 pandemic would have contributed to improving the safety of all emergency patients and reducing in-hospital mortality by preventing excessive deaths.
서울지역 미세먼지가 호흡기계 질환으로 입원한 환자에 미치는 영향
박해용,박윤숙,Pak, Hae-Yong,Pak, Yun-Suk 중소기업융합학회 2019 융합정보논문지 Vol.9 No.6
서울지역의 호흡기질환으로 입원한 환자를 대상으로 미세먼지 노출에 대한 건강영향을 평가하였다. 건강보험공단의 2002-2010년 동안 표본코호트의 만성폐쇄성 폐 질환(COPD), 천식 및 폐렴과 같은 호흡기 질환으로 입원한 13,974명의 환자를 대상자로 하였다. 추적관찰 기간동안 미세먼지 농도가 50ug/m3 이상에서 10ug/m3 증가할 때 15세 미만의 연령층에서는 1.38%, 65세 이상의 연령층에서는 1.62%, 75세 이상 연령층에서는 2.87% 호흡기질환으로 입원이 증가하였고, 폐렴환자는 1.50%, COPD 환자는 1.51%, 폐렴 및 천식환자는 1.55% 입원이 증가하였다. 또한 미세먼지가 80ug/m3 이상에서는 65세 이상 연령층에서 3.71%, 75세 이상 연령층에서 4.25% 입원환자가 증가하였다. 높은 미세먼지농도와 호흡기 질환으로 입원한 환자들과, 특히 노인에서 관련성이 높게 나타났다. 이미 호흡기 질환이 있었던 사람들, 특히 나이가 많은 환자는 고농도의 미세먼지에 노출되지 않도록 주의해야 한다. This cohort study aimed to identify the effects of daily PM10 exposure on the hospital admission of patients with respiratory diseases, during the nine-year period (2002-2010), in Seoul, Korea. The research subjects were 13,974 patients who had been hospitalized with respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia. During the follow-up period, an increase of 10 ug/m3 in PM10 under the threshold of 50 ug/m3 of PM10 led to hospital admission in 1.38% of the age group younger than 15 years, 1.62% in those 65 years or older, 2.87% in patients 75 years or older and in 1.50% of pneumonia patients, 1.51% of COPD patients, and 1.55% of pneumonia and asthma patients. Under the threshold of 80 ug/m3 of PM10, there was a 3.71% increase in new patients admitted in the age group 65 years or older and 4.25% in those at least 75 years old. Our study found that high PM10 was associated with increased risk of admission of respiratory patients, especially in the elderly. People who already have a respiratory disease should refrain from exposure to particulate matter when there is a high concentration of PM10, especially older patients.
The Effects of PM10 on the Hospital Admission of Patients with Respiratory Disease in Seoul, Korea
Hae-Yong Pak,Yun-Suk Pak 중소기업융합학회 2019 융합정보논문지 Vol.9 No.6
서울지역의 호흡기질환으로 입원한 환자를 대상으로 미세먼지 노출에 대한 건강영향을 평가하였다. 건강보험공단의 2002-2010년 동안 표본코호트의 만성폐쇄성 폐 질환(COPD), 천식 및 폐렴과 같은 호흡기 질환으로 입원한 13,974명의 환자를 대상자로 하였다. 추적관찰 기간동안 미세먼지 농도가 50ug/m3 이상에서 10ug/m3 증가할 때 15세 미만의 연령 층에서는 1.38%, 65세 이상의 연령층에서는 1.62%, 75세 이상 연령층에서는 2.87% 호흡기질환으로 입원이 증가하였고, 폐렴환자는 1.50%, COPD 환자는 1.51%, 폐렴 및 천식환자는 1.55% 입원이 증가하였다. 또한 미세먼지가 80ug/m3 이상 에서는 65세 이상 연령층에서 3.71%, 75세 이상 연령층에서 4.25% 입원환자가 증가하였다. 높은 미세먼지농도와 호흡기 질환으로 입원한 환자들과, 특히 노인에서 관련성이 높게 나타났다. 이미 호흡기 질환이 있었던 사람들, 특히 나이가 많은 환자는 고농도의 미세먼지에 노출되지 않도록 주의해야 한다. This cohort study aimed to identify the effects of daily PM10 exposure on the hospital admission of patients with respiratory diseases, during the nine-year period (2002–2010), in Seoul, Korea. The research subjects were 13,974 patients who had been hospitalized with respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia. During the follow-up period, an increase of 10 ug/m3 in PM10 under the threshold of 50 ug/m3 of PM10 led to hospital admission in 1.38% of the age group younger than 15 years, 1.62% in those 65 years or older, 2.87% in patients 75 years or older and in 1.50% of pneumonia patients, 1.51% of COPD patients, and 1.55% of pneumonia and asthma patients. Under the threshold of 80 ug/m3 of PM10, there was a 3.71% increase in new patients admitted in the age group 65 years or older and 4.25% in those at least 75 years old. Our study found that high PM10 was associated with increased risk of admission of respiratory patients, especially in the elderly. People who already have a respiratory disease should refrain from exposure to particulate matter when there is a high concentration of PM10, especially older patients.