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Vishrut K. Srinivasan,Shano Naseem,Neelam Varma,Deepesh P. Lad,Pankaj Malhotra 대한혈액학회 2020 Blood Research Vol.55 No.3
BackgroundChronic lymphocytic leukemia (CLL) is a heterogeneous disease, which is attributed to differences in the genetic characteristics of the leukemic clone. We studied the genomic profile of 52 treatment-naïve CLL patients. MethodsGenetic analysis was performed by multiplex ligation-dependent probe amplification (MLPA) using the SALSA P038 Probemix (MRC Holland, Amsterdam), which contains probes for 2p (MYCN,ALK,REL), 6q, 8p (TNFRSF10A/B), 8q (EIF3H,MYC), 9p21 (CDKN2A/B), 10q (PTEN), 11q (ATM, RDX, PPP2R1B, CADM1), chromosome 12, 13q14 (RB1, DLEU1/2/7, KCNRG, MIR15A), 14q, 17p (TP53) and chromosome 19, and for NOTCH1 7541-7542delCT, SF3B1 K700E, and MYD88 L265P mutations.ResultsThe median age was 65 years (male:female=2:1). The median hemoglobin, total leuko- cyte, and platelet counts were 12.4 g/dL, 57.7×109/L, and 176.5×109/L, respectively. At least one genetic abnormality was observed in 34 (65%) patients. The most common ab-normality was del(13q14) (deleted DLEU2 and DLEU1/RB1 genes), which was observed in 22 (42%) cases, followed by trisomy 12 [7 (13%) cases]. Del(11q) (deleted ATM, RDX11/PPP2R1B-4) and del(17p) (deleted TP53) were present in 5 (10%) and 2 (4%) cas-es, respectively. 19p13.2 (CDKN2D-2) amplification and NOTCH1 mutation were found in one case each.ConclusionGenetic abnormalities are commonly (65%) observed in CLL patients. Del(13q), which is associated with DLEU2 and DLEU1/RB1 gene deletion, was the most common. Compared with other abnormalities, del(11q) and del(17p) patients presented with cyto-penia and higher Binet stage, while those with del(13q14) had a longer time to first treatment.
Crystal Structure Analysis of 3-(4-ethylphenyl)-3-Hchromeno[4,3-c]isoxazole-3a(4H)-carbonitrile
P. Malathy, Jagadeesan Ganapathy, J. Srinivasan, Bakthadoss Manickam 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.4
초록 The crystal structure of the potential active 3-(4-ethylphenyl)-3H-chromeno[4,3-c] isoxazole-3a(4H)-carbonitrile (C19H16N2O2) has been determined from single crystal X-ray diffraction data. In the title compound crystallizes in the monoclinic space group P21/c with unit cell dimension a=6.6869 (8) Å, b=15.8326 (19) Å and c= 15.237 (2) Å [α=90°, β= 100.663° and γ= 90°]. In the structure chromene, isoxazole and carboxylate are almost coplanar each other. All geometrical parameters revelled that chromene ring of pyran ring adopt sofa conformation. The crystal packing is stabilized by intermolecular C-H...N and C-H...O hydrogen bond interaction.
P. Malathy, P. Sharmila, J. Srinivasan, Bakthadoss Manickam, S. Aravindhan 조선대학교 기초과학연구원 2016 조선자연과학논문집 Vol.9 No.2
The crystal structure of the potential active Methyl 8-bromo-3-phenyl-5a,9a-dihydro-3H- chromen [4,3-c][1,2] isoxazole- 3a(4H)- carboxylate (C18H15BrNO4) has been determined from single crystal X-ray diffraction technique. The title compound crystallizes in the triclinic space group Pī with unit cell dimension a=8.3129 (3) Å, b=9.5847 (4) Å and c= 11.1463(4) Å [α= 98.457(3)°, β= 102.806(2)° and γ= 105.033(5)°]. Single crystals suitable for X-ray diffraction were obtained by slow evaporation method, the isoxazole and six membered pyran rings adopts envelope conformation. In the crystal, molecules are linked via pairs of inter molecular C-H…O hydrogen bonds to form dimmers.
Malathy, P.,Sharmila, P.,Srinivasan, J.,Manickam, Bakthadoss,Aravindhan, S. The Basic Science Institute Chosun University 2016 조선자연과학논문집 Vol.9 No.2
The crystal structure of the potential active Methyl 8-bromo-3-phenyl-5a,9a-dihydro-3H-chromen [4,3-c][1,2] isoxazole-3a(4H)-carboxylate ($C_{18}H_{15}BrNO_4$) has been determined from single crystal X-ray diffraction technique. The title compound crystallizes in the triclinic space group Pī with unit cell dimension a=8.3129 (3) ${\AA}$, b=9.5847 (4) ${\AA}$ and c=11.1463(4) ${\AA}$ [${\alpha}=98.457(3)^{\circ}$, ${\beta}=102.806(2)^{\circ}$ and ${\gamma}=105.033(5)^{\circ}$]. Single crystals suitable for X-ray diffraction were obtained by slow evaporation method, the isoxazole and six membered pyran rings adopts envelope conformation. In the crystal, molecules are linked via pairs of inter molecular $C-H{\ldots}O$ hydrogen bonds to form dimmers.
A Semiconducting Organic Radical Cationic Host–Guest Complex
Fahrenbach, Albert C.,Sampath, Srinivasan,Late, Dattatray J.,Barnes, Jonathan C.,Kleinman, Samuel L.,Valley, Nicholas,Hartlieb, Karel J.,Liu, Zhichang,Dravid, Vinayak P.,Schatz, George C.,Van Duyne, R American Chemical Society 2012 ACS NANO Vol.6 No.11
<P>The self-assembly and solid-state semiconducting properties of single crystals of a trisradical tricationic complex composed of the diradical dicationic cyclobis(paraquat-<I>p</I>-phenylene) (CBPQT<SUP>2(•+)</SUP>) ring and methyl viologen radical cation (MV<SUP>•+</SUP>) are reported. An organic field effect transistor incorporating single crystals of the CBPQT<SUP>2(•+)</SUP>⊂MV<SUP>•+</SUP> complex was constructed using lithographic techniques on a silicon substrate and shown to exhibit <I>p</I>-type semiconductivity with a mobility of 0.05 cm<SUP>2</SUP> V<SUP>–1</SUP> s<SUP>–1</SUP>. The morphology of the crystals on the silicon substrate was characterized using scanning electron microscopy which revealed that the complexes self-assemble into “molecular wires” observable by the naked-eye as millimeter long crystalline needles. The nature of the recognition processes driving this self-assembly, radical–radical interactions between bipyridinium radical cations (BIPY<SUP>•+</SUP>), was further investigated by resonance Raman spectroscopy in conjunction with theoretical investigations of the vibrational modes, and was supported by X-ray structural analyses of the complex and its free components in both their radical cationic and dicationic redox states. These spectroscopic investigations demonstrate that the bond order of the BIPY<SUP>•+</SUP> radical cationic units of host and guest components is not changed upon complexation, an observation which relates to its conductivity in the solid-state. We envision the modularity inherent in this kind of host–guest complexation could be harnessed to construct a library of custom-made electronic organic materials tailored to fit the specific needs of a given electronic application.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-11/nn303553z/production/images/medium/nn-2012-03553z_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn303553z'>ACS Electronic Supporting Info</A></P>
Singu, B.S.,Male, U.,Srinivasan, P.,Yoon, K.R. THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2017 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.49 No.-
<P>Multi-walled carbon nanotubes (MWNTs), and titanium oxide (TiO2) were incorporated in polyaniline (PANI) to enhance the pseudocapacitance and cycle stability of PANI. PANI-MWNTs-TiO2, ternary composite was prepared by in-situ chemical polymerization of aniline in the presence of MWNTs and TiO2. Morphology analysis of ternary composite revealed the uniform covering of MWNTs by PANI nanofibers and TiO2 nanoparticles. The specific capacitance of PANI-MWNTs-TiO2 is 270 Fg-1, much higher than that of MWNTs (30 Fg(-1)) and PANI (210 Fg(-1)) electrodes. PANI-MWNTs-TiO2 showed good rate capability with excellent cycling stability. (C) 2017 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.</P>