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- 저자 : Owoyele, Bamidele Victor (검색결과 8 건)
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Traditional oil palm (Elaeis guineensis jacq.) and its medicinal uses: A review
Bamidele Victor Owoyele,Gbenga Opeyemi Owolabi 셀메드 세포교정의약학회 2014 셀메드 (CellMed) Vol.4 No.3
The oil palm ( Elaeis guineensis Jacq.) has been reported to originate along the gulf of the guinea in West Africa. The various parts of the tree have been used locally and traditionally for various medicinal purposes. Some of these uses have been proved by scientific experiments. Palm oil is extracted from the mesocarp of the fruit and is used traditionally for the treatment of headaches, pains, rheumatism, cardiovascular diseases, arterial thrombosis and an atherosclerosis due to its rich phytonutrients. The leaves are also used for the treatment of cancer, cardiovascular diseases, kidney diseases and wound healing. The sap also has been found to be rich in phytonutrients that can be used to treat various diseases. This review therefore seeks to explore many of the uses of the oil palm using the various parts of the oil palm.
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Analgesic and Anti-Inflammatory Effects of Aqueous Extract of Zea mays Husk in Male Wistar Rats
Bamidele V. Owoyele,Muhammed N. Negedu,Samuel O. Olaniran,Samuel A. Onasanwo,Stephen O. Oguntoye,Joseph O. Sanya,Sabitiu A. Oyeleke,Adekemi J. Ibidapo,Ayodele O. Soladoye 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
The analgesic and anti-inflammatory activities of Zea mays husk extract (25, 50, 100, and 200mg/kg of body weight) were investigated in rats. The hot plate and formalin-induced paw licking models were used to assess analgesic effects of the extract, whereas the carrageenan and cotton pellet models were used for the evaluation of anti-inflammatory activity. The extract at 25, 50, 100, and 200mg/kg body weight significantly (P<.05) reduced pain stimuli and inflammatory activity when compared with the control group. The reductions in paw licking time and granuloma weight in the formalin and cotton pellet models were both dose dependent. Also, the 200mg/kg doses of the extract produced higher effects compared with indomethacin (5mg/kg body of weight) in all the tests. These observations suggest that Z. mays husk extract may have analgesic and anti-inflammatory effects that may be due to its tannins and polyphenolic constituents. These results provide scientific validation for the use of Z. mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine.
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Bamidele Victor Owoyele,Ahmed Olalekan Bakare,Olutayo Folajimi Olaseinde,Mohammed Jelil Ochu,Akorede Munirdeen Yusuff,Favour Ekebafe,Oluwadamilare Lanre Fogabi,Treister Roi 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.3
Background: Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats. Methods: Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8) treated with normal saline/acetaminophen/acetaminophen + L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia were assessed using hotplate and von Frey tests, respectively. Investigation of spinal proinflammatory cytokines and antioxidant system were carried out after twenty-one days of treatment. Results: The results showed that the co-administration of acetaminophen and Lcarnosine significantly (P < 0.001) increased the paw withdrawal threshold to thermal and mechanical stimuli in ligated rats compared to the ligated naïve group. There was a significant (P < 0.001) decrease in the levels of nuclear factor kappa light chain enhancer B cell inhibitor, calcium ion, interleukin-1-beta, and tumour necrotic factor-alpha in the spinal cord of the group coadministered with acetaminophen and L-carnosine compared to the ligated control group. Co-administration with acetaminophen and L-carnosine increased the antioxidant enzymatic activities and reduced the lipid peroxidation in the spinal cord. Conclusions: Co-administration of acetaminophen and L-carnosine has anti-inflammatory effects as a mechanism that mediate its antinociceptive effects in CCIinduced peripheral neuropathy in Wistar rat.
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Patrick Oluwole Abolarin,Bamidele Victor Owoyele 환경독성보건학회 2024 환경독성보건학회지 Vol.39 No.2
Chronic exposure to glyphosate-based herbicide (Gly) has been associated with neurological disorders. Tannic acid (TA) is an antioxidant with attenuating action against neuroinflammation-associated conditions. This study evaluated the effect of Gly on pain perception alongside antinociceptive and anti-inflammatory actions of TA in Gly-exposed mice. Male Swiss mice were randomly divided into six groups (n=8): control (distilled water 0.2 ml/kg), Gly (Gly 500 mg/kg), Pre-TA + Gly (TA 50 mg/kg pre-treatment, afterwards Gly-administered), TA + Gly (TA 50 mg/kg and Gly co-administered), Pre-AA + Gly (ascorbic acid (AA) 10 mg/kg pre-treatment, afterwards Gly-administered), and AA + Gly (AA 10 mg/kg and Gly co-administered). Mechanical, thermal, and chemical pain were evaluated six weeks post vehicle/drugs administrations orally, followed by brain biochemical measurements. TA treatment alleviated Gly-induced hyperalgesia in similar version to the values of control and AA groups by increasing significantly (p < 0.05) nociceptive thresholds. Moreover, TA-treatment significantly decreased malondialdehyde (MDA) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) levels, significantly increased anti-inflammatory cytokines (IL-10, IL-4, and TGF-1β) levels, and antioxidant enzymes, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities compared to Gly-treated mice (p < 0.05). Conclusively, TA treatment exerted antinociceptive and anti-inflammatory actions, possibly through its antioxidant and anti-inflammatory actions in Gly-exposed mice. Notably, TA pre-treatment showed a better response than TA and Gly co-administration. We propose the potential neuroprotective and ameliorative functions of TA in Gly-induced hyperalgesia. This merits further clinical research into protective roles of TA against pesticide-related conditions.
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Ahmed Olalekan Bakare,Bamidele Victor Owoyele 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.1
Background: The continuous search for a novel neuropathic pain drug with few or no side effects has been a main focus of researchers for decades. This study investigated the antinociceptive and neuroprotective effects of bromelain in sciatic nerve ligation-induced neuropathic pain in Wistar rats. Methods: Forty-eight Wistar rats randomly divided into eight groups comprised of six animals each were used for this study. Peripheral neuropathy was induced via chronic constriction of the common sciatic nerve. Thermal hyperalgesic and mechanical allodynia were assessed using a hotplate and von Frey filaments, respectively. The functional recovery and structural architecture of the ligated sciatic nerve were evaluated using the sciatic functional index test and a histological examination of the transverse section of the sciatic nerve. The neuroprotective effects of bromelain were investigated in the proximal sciatic nerve tissue after 21 days of treatment. Results: Bromelain significantly (P < 0.05) attenuated both the thermal hyperalgesia and mechanical allodynic indices of neuropathic pain. There were improvements in sciatic function and structural integrity in rats treated with bromelain. These rats showed significant (P < 0.05) increases in sciatic nerve nuclear transcription factors (nuclear factor erythroid-derived-2-related factors-1 [NrF-1] and NrF-2), antioxidant enzymes (superoxide dismutase and glutathione), and reduced membranelipid peroxidation compared with the ligated control group. Conclusions: This study suggest that bromelain mitigated neuropathic pain by enhancing the activities of nuclear transcription factors (NrF-1 and NrF-2) which increases the antioxidant defense system that abolish neuronal stress and structural disorganization.
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Aboyeji Lukuman Oyewole,Bamidele Victor Owoyele 셀메드 세포교정의약학회 2012 TANG Vol.2 No.4
This study was carried out to investigate the neurobehavioural effects of the smoking of Carica papaya leaves based on ethnopharmacological information. Twenty -four rats used for the study were grouped into four groups namely; Groups 1 (Control, unexposed to any smoke) and Groups 2 - 4 (exposed to smoke from varying amount of pawpaw leaf powder). Groups 2, 3, and 4 were exposed to smoke from 6.25 g (low dose), 12.50 g (medium dose), and 18.75 g (high dose) of dry pawpaw leaves respectively in a smoking chamber twice daily for 21 one days with each exposure lasting 3 min. The spontaneous motor activities and locomotory behaviour of the animals were assessed using an open field maze and hole board maze test. The results showed that the smoking of Carica papaya leaves led to a significant (p < 0.05) increase in locomotory activities from 33.36 ± 3.36 (control) to 66.50 ± 6.16 (high dose), number of head dips (from 8.50 ± 0.36, to 12.83 ± 0.87) and rearing behaviour (from 14.83 ± 0.74, to 27.0 ± 1.46). However, the freezing durations as animals were introduced into the maze and grooming behaviour were significantly (p < 0.05) reduced in the treated groups. In conclusion, the increased ambulations and exploratory behaviours imply that the anxiety level is low in the treated groups compared to the control group which thus confirms that dry Carica papaya leaf may possibly contain psychoactive substance(s) that become active when smoked.
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A. O. Bakare,A. L. Oyewole,B. V. Owoyele 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
Diverse etiology of neuropathic pain conditions demands new understanding of its pathogenesis and development of efective therapy. Treatment of induced neuropathic pain using aqueous Adansonia digitata bark extract has not been investigated. We probed the systemic administration efects of A. digitata bark extract on sciatic nerve ligated induced neuropathic pain. Treatments with extract caused increased pain threshold on hot plate, hot- and cold-immersion test. Notably, an apparent decreased in systemic prostaglandin E2 occurred concurrently with strengthened oxidative defense system. By contrast, extract-hexamethonium, -propranolol, -atropine or -prazosin cotreatments in induced-neuropathic rats suggested no involvement of muscarinic, nicotinic, beta or alpha-1 receptors in the analgesic action of the extract. Though, a weaken oxidative defense system was observed based on oxidative markers measured. These results indicate the crude extract ability to induce pain relief in neuropathic pain and this coincides with degree of decreased PGE2 and increased antioxidants as well as decreased lipid peroxidation product. This is the frst report demonstrating the usefulness of aqueous A. digitata bark extract in the management of neuropathic pain, an action that involves alteration of PGE2 and oxidative defense system.
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