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Higgs phenomenology in the minimalSU(3)L×U(1)Xmodel
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta,Yagyu, Kei American Physical Society 2016 Physical Review D Vol.94 No.1
<P>We investigate the phenomenology of a model based on the SU(3)(c) x SU(3)(L) x U(1)(X) gauge theory, the so-called 331 model. In particular, we focus on the Higgs sector of the model which is composed of three SU(3)L triplet Higgs fields and is the minimal form for realizing a phenomenologically acceptable scenario. After the spontaneous symmetry breaking SU(3)(L) x U(1)(X) -> SU(2)(L) x U(1)(Y), our Higgs sector effectively becomes that with two SU(2)(L) doublet scalar fields, in which the first-and the second-generation quarks couple to a different Higgs doublet from that which couples to the third-generation quarks. This structure causes the flavor-changing neutral current mediated by Higgs bosons at the tree level. By taking an alignment limit of the mass matrix for the CP-even Higgs bosons, which is naturally realized in the case with the breaking scale of SU(3)(L) x U(1)(X) much larger than that of SU(2)(L) x U(1)(Y), we can avoid current constraints from flavor experiments such as the B-0-(B) over bar (0) mixing even for the Higgs bosons masses that are O(100) GeV. In this allowed parameter space, we clarify that a characteristic deviation in quark Yukawa couplings of the Standard Model-like Higgs boson is predicted, which has a different pattern from that seen in two Higgs doublet models with a softly broken Z(2) symmetry. We also find that the flavor-violating decay modes of the extra Higgs boson, e.g., H/A -> tc and H-+/- -> ts, can be dominant, and they yield the important signature to distinguish our model from the two Higgs doublet models.</P>
Radiative seesaw mechanism in a minimal 3-3-1 model
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta American Physical Society 2016 Physical Review D Vol.93 No.7
<P>We study the neutrino sector in a minimal SU(3)(L) x U(1)(X) model, in which its mass is generated at a one-loop level with the charged lepton mass, and hence, there exists a strong correlation between the charged-lepton mass and the neutrino mass. We identify the parameter region of this model to satisfy the current neutrino oscillation data as well as the constraints on lepton flavor violating processes. We also discuss a possibility to explain the muon anomalous magnetic moment.</P>
Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions
Seigo Okada,Yuichi Ishikawa,Maiko Shimomura,Shinpei Sunagawa,Reiji Hirano,Shinnosuke Fukunaga,Akiko Miyake,Yusuke Okada,Takashi Maki 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.3
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-oldgirl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx,cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severepain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which wasdetected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmonella spp issensitive. Echocardiography performed as screening for fever of unknown origin revealed medium-sized aneurysms of the leftanterior descending artery. EN masked the diagnosis of KD, and the patient developed a coronary artery lesion. KD should beconsidered in the differential diagnosis of refractory EN in pediatric patients.
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>