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Radiative seesaw mechanism in a minimal 3-3-1 model
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta American Physical Society 2016 Physical Review D Vol.93 No.7
<P>We study the neutrino sector in a minimal SU(3)(L) x U(1)(X) model, in which its mass is generated at a one-loop level with the charged lepton mass, and hence, there exists a strong correlation between the charged-lepton mass and the neutrino mass. We identify the parameter region of this model to satisfy the current neutrino oscillation data as well as the constraints on lepton flavor violating processes. We also discuss a possibility to explain the muon anomalous magnetic moment.</P>
Higgs phenomenology in the minimalSU(3)L×U(1)Xmodel
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta,Yagyu, Kei American Physical Society 2016 Physical Review D Vol.94 No.1
<P>We investigate the phenomenology of a model based on the SU(3)(c) x SU(3)(L) x U(1)(X) gauge theory, the so-called 331 model. In particular, we focus on the Higgs sector of the model which is composed of three SU(3)L triplet Higgs fields and is the minimal form for realizing a phenomenologically acceptable scenario. After the spontaneous symmetry breaking SU(3)(L) x U(1)(X) -> SU(2)(L) x U(1)(Y), our Higgs sector effectively becomes that with two SU(2)(L) doublet scalar fields, in which the first-and the second-generation quarks couple to a different Higgs doublet from that which couples to the third-generation quarks. This structure causes the flavor-changing neutral current mediated by Higgs bosons at the tree level. By taking an alignment limit of the mass matrix for the CP-even Higgs bosons, which is naturally realized in the case with the breaking scale of SU(3)(L) x U(1)(X) much larger than that of SU(2)(L) x U(1)(Y), we can avoid current constraints from flavor experiments such as the B-0-(B) over bar (0) mixing even for the Higgs bosons masses that are O(100) GeV. In this allowed parameter space, we clarify that a characteristic deviation in quark Yukawa couplings of the Standard Model-like Higgs boson is predicted, which has a different pattern from that seen in two Higgs doublet models with a softly broken Z(2) symmetry. We also find that the flavor-violating decay modes of the extra Higgs boson, e.g., H/A -> tc and H-+/- -> ts, can be dominant, and they yield the important signature to distinguish our model from the two Higgs doublet models.</P>
Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions
Seigo Okada,Yuichi Ishikawa,Maiko Shimomura,Shinpei Sunagawa,Reiji Hirano,Shinnosuke Fukunaga,Akiko Miyake,Yusuke Okada,Takashi Maki 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.3
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-oldgirl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx,cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severepain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which wasdetected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmonella spp issensitive. Echocardiography performed as screening for fever of unknown origin revealed medium-sized aneurysms of the leftanterior descending artery. EN masked the diagnosis of KD, and the patient developed a coronary artery lesion. KD should beconsidered in the differential diagnosis of refractory EN in pediatric patients.
Explainable artificial intelligence in emergency medicine: an overview
Okada Yohei,Ning Yilin,Ong Marcus Eng Hock 대한응급의학회 2023 Clinical and Experimental Emergency Medicine Vol.10 No.4
Artificial intelligence (AI) and machine learning (ML) have potential to revolutionize emergency medical care by enhancing triage systems, improving diagnostic accuracy, refining prognostication, and optimizing various aspects of clinical care. However, as clinicians often lack AI expertise, they might perceive AI as a “black box,” leading to trust issues. To address this, “explainable AI,” which teaches AI functionalities to end-users, is important. This review presents the definitions, importance, and role of explainable AI, as well as potential challenges in emergency medicine. First, we introduce the terms explainability, interpretability, and transparency of AI models. These terms sound similar but have different roles in discussion of AI. Second, we indicate that explainable AI is required in clinical settings for reasons of justification, control, improvement, and discovery and provide examples. Third, we describe three major categories of explainability: pre-modeling explainability, interpretable models, and post-modeling explainability and present examples (especially for post-modeling explainability), such as visualization, simplification, text justification, and feature relevance. Last, we show the challenges of implementing AI and ML models in clinical settings and highlight the importance of collaboration between clinicians, developers, and researchers. This paper summarizes the concept of “explainable AI” for emergency medicine clinicians. This review may help clinicians understand explainable AI in emergency contexts.
Precision measurement of the 3d->2p x-ray energy in kaonic <sup>4</sup>He
Okada, S.,Beer, G.,Bhang, H.,Cargnelli, M.,Chiba, J.,Choi, S.,Curceanu, C.,Fukuda, Y.,Hanaki, T.,Hayano, R.S.,Iio, M.,Ishikawa, T.,Ishimoto, S.,Ishiwatari, T.,Itahashi, K.,Iwai, M.,Iwasaki, M.,Juhasz, North-Holland Pub. Co 2007 Physics letters: B Vol.653 No.5
We have measured the Balmer-series x-rays of kaonic <SUP>4</SUP>He atoms using novel large-area silicon drift x-ray detectors in order to study the low-energy K@?-nucleus strong interaction. The energy of the 3d->2p transition was determined to be 6467+/-3(stat)+/-2(syst) eV. The resulting strong-interaction energy-level shift is in agreement with theoretical calculations, thus eliminating a long-standing discrepancy between theory and experiment.
Erectile Dysfunction in Germ Cell Tumor Survivors
Okada Koichi,Fujita Kazutoshi,Fukuhara Shinichiro,Kiuchi Hiroshi,Uemura Motohide,Imamura Ryoichi,Nonomura Norio 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.3
Purpose: Germ cell tumors (GCTs) are the most common malignant neoplasms in adolescents and young adults, and most patients with these tumors can be completely cured. Therefore, maintaining quality of life (QOL) is important. Erectile dysfunction (ED) is one factor that reduces the QOL of GCT survivors. We aimed to clarify the relationship between ED and age, follow-up period, serum levels of hormones, and treatment methods for GCT survivors. Materials and Methods: We evaluated ED using the Sexual Health Inventory for Men questionnaire (SHIM) and measured serum levels of hormones in survivors after GCT treatment. The relationships between the SHIM score responses and age, serum levels of hormones, follow-up period, and treatment methods were assessed using a logistic analysis. Results: Fifty-two GCT survivors were enrolled and 46 survivors completed the SHIM. The median age, follow-up period, and SHIM score were 38 years, 35 months, and 18, respectively. Regarding the SHIM scores, 85% had scores <22 and 46% had scores <17. The percentage of SHIM scores <17 was 69% in patients with under 2 years of follow-up. It significantly improved to 33% in patients with over 2 years of follow-up. The multivariate analysis identified the follow-up period as an independent factor for SHIM scores <17. Age, serum levels of hormone, and treatment method were not significant factors for SHIM scores <17. Conclusions: Improvement of SHIM score can be expected after GCT treatment regardless of age, serum levels of hormone, and treatment method.