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Higgs phenomenology in the minimalSU(3)L×U(1)Xmodel
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta,Yagyu, Kei American Physical Society 2016 Physical Review D Vol.94 No.1
<P>We investigate the phenomenology of a model based on the SU(3)(c) x SU(3)(L) x U(1)(X) gauge theory, the so-called 331 model. In particular, we focus on the Higgs sector of the model which is composed of three SU(3)L triplet Higgs fields and is the minimal form for realizing a phenomenologically acceptable scenario. After the spontaneous symmetry breaking SU(3)(L) x U(1)(X) -> SU(2)(L) x U(1)(Y), our Higgs sector effectively becomes that with two SU(2)(L) doublet scalar fields, in which the first-and the second-generation quarks couple to a different Higgs doublet from that which couples to the third-generation quarks. This structure causes the flavor-changing neutral current mediated by Higgs bosons at the tree level. By taking an alignment limit of the mass matrix for the CP-even Higgs bosons, which is naturally realized in the case with the breaking scale of SU(3)(L) x U(1)(X) much larger than that of SU(2)(L) x U(1)(Y), we can avoid current constraints from flavor experiments such as the B-0-(B) over bar (0) mixing even for the Higgs bosons masses that are O(100) GeV. In this allowed parameter space, we clarify that a characteristic deviation in quark Yukawa couplings of the Standard Model-like Higgs boson is predicted, which has a different pattern from that seen in two Higgs doublet models with a softly broken Z(2) symmetry. We also find that the flavor-violating decay modes of the extra Higgs boson, e.g., H/A -> tc and H-+/- -> ts, can be dominant, and they yield the important signature to distinguish our model from the two Higgs doublet models.</P>
Radiative seesaw mechanism in a minimal 3-3-1 model
Okada, Hiroshi,Okada, Nobuchika,Orikasa, Yuta American Physical Society 2016 Physical Review D Vol.93 No.7
<P>We study the neutrino sector in a minimal SU(3)(L) x U(1)(X) model, in which its mass is generated at a one-loop level with the charged lepton mass, and hence, there exists a strong correlation between the charged-lepton mass and the neutrino mass. We identify the parameter region of this model to satisfy the current neutrino oscillation data as well as the constraints on lepton flavor violating processes. We also discuss a possibility to explain the muon anomalous magnetic moment.</P>
Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions
Seigo Okada,Yuichi Ishikawa,Maiko Shimomura,Shinpei Sunagawa,Reiji Hirano,Shinnosuke Fukunaga,Akiko Miyake,Yusuke Okada,Takashi Maki 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.3
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-oldgirl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx,cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severepain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which wasdetected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmonella spp issensitive. Echocardiography performed as screening for fever of unknown origin revealed medium-sized aneurysms of the leftanterior descending artery. EN masked the diagnosis of KD, and the patient developed a coronary artery lesion. KD should beconsidered in the differential diagnosis of refractory EN in pediatric patients.
Effect of degenerate particles on internal bremsstrahlung of Majorana dark matter
Okada, H.,Toma, T. North-Holland Pub. Co 2015 Physics letters. Section B Vol.750 No.-
Gamma-rays induced by annihilation or decay of dark matter can be its smoking gun signature. In particular, gamma-rays generated by internal bremsstrahlung of Majorana and real scalar dark matter is promising since it can be a leading emission of sharp gamma-rays. However in the case of Majorana dark matter, its cross section for internal bremsstrahlung cannot be large enough to be observed by future gamma-ray experiments if the observed relic density is assumed to be thermally produced. In this paper, we introduce some degenerate particles with Majorana dark matter, and show they lead enhancement of the cross section. As a result, increase of about one order of magnitude for the cross section is possible without conflict with the observed relic density, and it would be tested by the future gamma-ray experiments such as GAMMA-400 and Cherenkov Telescope Array (CTA). In addition, the constraints of perturbativity, positron observation by the AMS experiment and direct search for dark matter are discussed.
Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
Okada, Jun-ichi,Washio, Takumi,Sugiura, Seiryo,Hisada, Toshiaki The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted drug-induced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http://ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.
TWO POINTS DISTORTION ESTIMATES FOR CONVEX UNIVALENT FUNCTIONS
Okada, Mari,Yanagihara, Hiroshi Korean Mathematical Society 2018 대한수학회보 Vol.55 No.3
We study the class $C{\mathcal{V}} ({\Omega})$ of analytic functions f in the unit disk ${\mathbb{D}}=\{z{\in}{\mathbb{C}}$ : ${\mid}z{\mid}$ < 1} of the form $f(z)=z+{\sum}_{n=2}^{\infty}a_nz^n$ satisfying $$1+\frac{zf^{{\prime}{\prime}}(z)}{f^{\prime}(z)}{\in}{\Omega},\;z{\in}{\mathbb{D}}$$, where ${\Omega}$ is a convex and proper subdomain of $\mathbb{C}$ with $1{\in}{\Omega}$. Let ${\phi}_{\Omega}$ be the unique conformal mapping of $\mathbb{D}$ onto ${\Omega}$ with ${\phi}_{\Omega}(0)=1$ and ${\phi}^{\prime}_{\Omega}(0)$ > 0 and $$k_{\Omega}(z)={\displaystyle\smashmargin{2}{\int\nolimits_{0}}^z}{\exp}\({\displaystyle\smashmargin{2}{\int\nolimits_{0}}^t}{\zeta}^{-1}({\phi}_{\Omega}({\zeta})-1)d{\zeta}\)dt$$. Let $z_0,z_1{\in}{\mathbb{D}}$ with $z_0{\neq}z_1$. As the first result in this paper we show that the region of variability $\{{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0)\;:\;f{\in}C{\mathcal{V}}({\Omega})\}$ coincides wth the set $\{{\log}\;k^{\prime}_{\Omega}(z_1z)-{\log}\;k^{\prime}_{\Omega}(z_0z)\;:\;{\mid}z{\mid}{\leq}1\}$. The second result deals with the case when ${\Omega}$ is the right half plane ${\mathbb{H}}=\{{\omega}{\in}{\mathbb{C}}$ : Re ${\omega}$ > 0}. In this case $CV({\Omega})$ is identical with the usual normalized class of convex univalent functions on $\mathbb{D}$. And we derive the sharp upper bound for ${\mid}{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0){\mid}$, $f{\in}C{\mathcal{V}}(\mathbb{H})$. The third result concerns how far two functions in $C{\mathcal{V}}({\Omega})$ are from each other. Furthermore we determine all extremal functions explicitly.