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Synthesis of 5'-substituted fluoro-neplanocin A analogues
Moon, Hyung-Ryong,Lee, Hyun-Joo,Kim, Kyung-Ran,Lee, Kang-Man,Lee, Sang-Kook,Kim, Hea-Ok,Chun, Moon-Woo,Jeong, Lak-Shin 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, using cyclopentenone derivative 2 as a key intermediate. The inhibitory activity against SAH was in the following order: NH₂>SH>F, N₃, indicating a hydrogen bonding donor such as OH or NH₂was essential for inhibitory activity. All the final compounds showed much less decreased cytotoxicity in two cancer cell lines(Col2 and A549), implying that phosphorylation of the 5'-hydroxyl group of fluoro-neplanocin A is closely related to its high cytotoxicity.
Mixed Osteosarcoma with Metastatic Alveolar Carcinomatous Appearance in Canine Mammary Gland Tumor
Moon-Jung Goo(구문정),Il-Hwa Hong(홍일화),Jin-Kyu Park(박진규),Hai-Jie Yang(양해걸),Dong-Wei Yuan(위엔동웨이),Mi-Ran Ki,(기미란),Hye-Rim Lee(이혜림),Kyung-Sook Hong(홍경숙),Jung-Youn Han(한정연),Ok-Kyung Hwang(황옥경),Tae-Hwan Kim,( 한국생명과학회 2007 생명과학회지 Vol.17 No.12
본 증례는 개의 유선에서 발생한 골형성성의 악성 혼합 유선 종양으로 샘포의 암종성 변화를 동반하고 있다. 종양은 12년령 암캐의 좌측 5번째 유선에서 절제되었으며 직경 2~2.5㎝의 단단한 mass로 절단 시 경도가 높은 골성의 구조를 가지고 있었다. 현미경학적 관찰 시, 골유사 물질이 미네랄 침착되고 있었으며 다수의 골형성 세포와 일부 파골세포가 골생성 종양 기질 전반에 걸쳐서 관찰되었다. 이러한 골유사 병변은 높은 밀집도를 보이는 근상피 세포와 연접하고 있었으며 이러한 세포들은 수 개의 유사분열상을 나타내고 있었다. 이와 더불어, 유선세관과 샘포의 암종성 변화를 보이는 세포들이 인접 기질로 침습하고 있는 모습이 관찰되었고 이것 역시 증가된 근상피 세포들로 둘러싸여 있었다. 본 증례에서 볼 수 있는 이러한 세포들의 출현은 동시 발생된 악성 종양의 형태를 제시할 수 있으며 종양의 기원은 상피 유래의 암종성 조직과 중간엽 유래의 육종성 연골 및 골 조직으로 구별할 수 있겠다. We describe here a case of malignant mixed osteogenic tumor of the mammary gland with alveolar carcinomatous appreance. A firm, 2 to 2.5cm (in diameter) mass under the 5th nipple, showing the structure of extraosseous osteogenic sarcoma, was removed from the left 5th mammary gland of 12-year-old female dog. When investigated under the microscope, the osteoid material undergoing mineralization was surrounded by numerous scattered osteoblasts and a few osteoclastic cells throughout the osteoid tumorous stroma. The osteoid lesions were continuous with hypercellular myoepithelial cells of a very immature character with several mitotic figures. In addition, there were also carcinomatous tubules and alveoli, with invading cells into peripheral stroma, surrounded by myoepithelial cells in the mammary gland. In these lesions, emanating cords of tumor cells appear to be continuous with the myoepithelial cell layer of a duct. The presence of all these cell types suggests the existence of a common malignant origin, the stem cell being differentiated into epithelial carcinomatous and mesenchymal sarcomatous chondral and osteogenic tissues.
Poster Display : Unilateral Aplasia of Uterine Horn with Ipsilateral Renal Agenesis in a Persian Cat
( Moon Jung Goo ),( Hai Ji Yang ),( Dong Wei Yuan ),( Il Hwa Hong ),( Jin Kyu Park ),( Mi Ran Ki ),( Hye Rim Lee ),( Kyung Sook Hong ),( Jung Youn Han ),( Ok Kyung Hwang ),( Seung Geun Lee ),( Sun Hee 한국수의병리학회 2007 한국수의병리학회 학술발표논문집 Vol.11 No.-
Poster Presentation : Splenolithiasis with Calcium Oxalate Cytolithiasis in a Female Dog
( Moon Jung Goo ),( Il Hwa Hong ),( Jin Kyu Park ),( Dong Wei Yuan ),( Mi Ran Ki ),( Kyung Sook Hong ),( Jung Youn Han ),( Ok Kyung Hwang ),( Ae Ri Ji ),( Sun Hee Do ),( Tae Hwan Kim ),( Kyu Shik Jeon 한국수의병리학회 2008 한국수의병리학회 학술발표논문집 Vol.12 No.2
Goo, Moon-Jung,Ki, Mi-Ran,Lee, Hye-Rim,Hong, Il-Hwa,Park, Jin-Kyu,Yang, Hai-Jie,Yuan, Dong-Wei,Hwang, Ok-Kyung,Do, Sun-Hee,Yoo, Sung-Eun,Jeong, Kyu-Shik Lippincott Williams Wilkins, Inc. 2008 European journal of gastroenterology & hepatology Vol.20 No.10
We report a case of primary biliary cirrhosis (PBC) that occurred in a 24-month-old male C57BL/6 mouse infected with Helicobacter pylori (H. pylori). Microscopically, the portal tract in the liver showed nonsuppurative destructive cholangitis with variable cytologic distortion of the epithelial cells and peribiliary lymphoplasmacytic infiltration. Immunohistochemistry using α-smooth muscle actin demonstrated fibrous bands associating with the wall of vasculature. The level of serum antivacuolating toxin IgG in this mouse showed the highest value (optical density=2.1470) of the H. pylori-infected group (n=13) (optical density=1.7168±0.1759, mean±SD). Spontaneously developed PBC-like lesions in C57BL/6 mice have been reported by several authors. However, this case strikingly resembles human PBC with its characterized histological features. Therefore, we propose that the increase in vacuolating toxin caused by H. pylori infection may be related to the development of PBC by molecular mimicry.
Helicobacter pylori promotes hepatic fibrosis in the animal model
Goo, Moon-Jung,Ki, Mi-Ran,Lee, Hye-Rim,Yang, Hai-Jie,Yuan, Dong-Wei,Hong, Il-Hwa,Park, Jin-Kyu,Hong, Kyung-Sook,Han, Jung-Youn,Hwang, Ok-Kyung,Kim, Dong-Hwan,Do, Sun-Hee,Cohn, Ronald D,Jeong, Kyu-Shik Springer Science and Business Media LLC 2009 Laboratory investigation Vol.89 No.11
<P>Helicobacter pylori infection has been reported to be very common in patients with chronic liver diseases, including cirrhosis. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl(4)) administration. We observed the histopathological changes and the presence of H. pylori genes by PCR in the liver. Significant increase in the fibrotic score as well as in serum alanine aminotransferase and aspartate aminotransferase levels was shown in the CCl(4)+H. pylori group compared with that in the CCl(4)-treated group. Compared with the CCl(4)-treated group, alpha-smooth muscle actin and transforming growth factor-beta1 were enhanced; however, senescence marker protein-30, a multifunctional protein protecting hepatocytes against oxidative stress and apoptosis, was suppressed in the CCl(4)+H. pylori group. The 16S rRNA (400 bp) was demonstrated by PCR for H. pylori genes from genomic DNA extracted from the liver, and H. pylori-infected mice showed 93.8% (15 of 16) seropositivity by contrast with seronegativity in all H. pylori-noninfected mice. In addition, immunohistochemical study against H. pylori showed positive antigen fragments in the liver of the infected groups. Consequently, our data suggest that H. pylori infection could be an important contributing infectious factor to the development of liver cirrhosis.</P>