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Chu Hongmin,Park Seongjun,Kang Kyungho,Lee Joohyun,Oh Jeewoo,Yoon Juwon,Piao Quanyu,Kim Jaehyo,Lee Sanghun 대한침도의학회 2023 대한침도의학회지 Vol.7 No.2
Background: Ultrasound-guided acupuncture has gained significance in diverse medical applications, particularly in enhancing the accuracy and safety of procedures. This tech- nique has shown promising results in clinical effectiveness and safety compared to tradi- tional methods. Methods: We conducted a comprehensive review of studies involving ultrasound-guided acupuncture, analyzing its accuracy and clinical impact. We explored various conditions, such as musculoskeletal pain syndromes, trigger finger, knee osteoarthritis, and more, to compare the efficacy of ultrasound-guided acupuncture against conventional techniques. Results: Ultrasound-guided acupuncture demonstrated enhanced accuracy in targeting specific anatomical structures, thereby improving the precision and effectiveness of the treatment. Studies highlighted its superiority in reducing complications and recurrence rates, particularly in conditions like trigger finger and knee osteoarthritis. Conclusion: The development and application of ultrasound technology in guiding acu- puncture procedures offer a safer and more effective approach to clinical practice. As ultrasound technology continues to advance, its integration with acupuncture can further refine and standardize protocols, potentially influencing future research and establishing standardized guidelines for practice.
Choi, Won Ho,Choi, Hye Ran,Seo, Eunsoo,Hwang, Jeewoo,Oh, Heekyung,Kim, Myeong Rae,Han, Su Rin,Kim, Min Seok,Kang, Seong-Hyeon,Lee, Youngjin Elsevier 2019 OPTIK -STUTTGART- Vol.183 No.-
<P><B>Abstract</B></P> <P>Magnetic resonance imaging (MRI) has many advantages and has developed various pulse sequences. In particular, the diffusion weighted image (DWI) technique is widely used because it can acquire images quickly during examination of stroke, through a proper adjustment of the diffusion-weighted gradient b-value. However, a setting with inappropriate b-value causes loss of image signal that increases the influence of noise. Therefore, in this study, we quantitatively evaluated image quality after applying a variety of algorithms to the image acquired by changing the b-value and the main magnetic field in the MRI device. To acquire the image, the phantom was self-produced with an acrylic panel and chicken breast. Wiener filter, total variation (TV), and our proposed fast non-local means (FNLM) noise reduction algorithms were applied to the image. Consequently, the signal intensity at a 3.0 T magnetic field increased by a factor 4.8 compared to a 1.5 T magnetic field. Moreover, the signal-to-noise ratio and contrast-to-noise ratio were highest with the FNLM algorithm, and the values increased by factors of 9.5 and 9.9 with a 1.5 T magnetic field and by factors of 9.9 and 5.0 with a 3.0 T magnetic field compared to the noise image, respectively. The result of time resolution, the Wiener filter appeared the finest value, but had no significant difference compared to FNLM algorithm. In conclusion, our results confirmed that the proposed FNLM noise reduction algorithm can acquire both improved image quality and high processing time in MRI imaging with the DWI technique.</P>
Cho, Tae-Min,Kim, Ji Young,Kim, Yoon-Jae,Sung, Daeil,Oh, Eunhye,Jang, Seojin,Farrand, Lee,Hoang, Van-Hai,Nguyen, Cong-Truong,Ann, Jihyae,Lee, Jeewoo,Seo, Jae Hong Elsevier 2019 Cancer letters Vol.447 No.-
<P><B>Abstract</B></P> <P>Triple-negative breast cancer (TNBC) is an aggressive heterogeneous disease with a divergent profile. It has an earlier tendency to form metastases and is associated with poor clinical outcomes due to the limited treatment options available. Heat-shock protein (HSP90) represents a potential treatment target as it promotes tumor progression and metastasis by modulating the maturation and stabilization of signal transduction proteins. We sought to investigate the efficacy of the C-terminal HSP90 inhibitor L80 on cell proliferation, breast cancer stem cell (BCSC)-like properties, tumor growth and metastasis. L80 suppressed cell viability and concomitantly inhibited AKT/MEK/ERK/JAK2/STAT3 signaling in TNBC cells but did not induce cytotoxicity in normal cells. L80 effectively targeted BCSC-like traits, together with significant reductions in the CD44high/CD24low-population, ALDH1 activity and mammosphere forming-ability. In support of the <I>in vitro</I> observations, L80 administration caused significant impairment in tumor growth, angiogenesis and distant metastases in an orthotopic allograft model with BCSC-enriched cells <I>in vivo</I>. These phenomena were associated with the suppression of BCSC-like characteristics and STAT3 dysfunction. Our findings highlight properties of the L80 compound that may be useful in suppressing metastatic TNBC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The C-terminal HSP90 inhibitor L80 targets cancer stem-like properties. </LI> <LI> L80 inhibits HSP90 client protein kinases including AKT, MEK, JAK and STAT3. </LI> <LI> L80 suppresses tumor growth and distant TNBC metastases <I>in vivo.</I> </LI> <LI> Antitumor activity of L80 is associated with dysregulation of STAT3 activation. </LI> </UL> </P>