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Dietary Total Antioxidant Capacity as a Useful Tool for Predicting Health Risk
Kyungho Ha,Ock K. Chun 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Diets rich in fruits and vegetables provide antioxidants, including vitamins C and E, carotenoids, and flavonoids, and dietary antioxidants suppress reactive oxygen species generation as radical scavengers. In a recent previous study, we evaluated the association between individual antioxidant vitamin intake and mortality risk in 20,602 US adults using the 1999-2010 the National Health and Nutrition Examination Survey (NHANES). During a median follow-up of 9.3 years, higher intake of vitamin E was associated with lower all-cause mortality and higher intake of vitamin A was associated with lower mortality from cardiovascular disease and cancer. These findings indicate that dietary antioxidant may have beneficial health effects. However, our usual diets consist of antioxidants in various chemical forms with different degrees of antioxidant capacities and these combined antioxidants may exert cumulative or synergistic effects. In this regard, dietary total antioxidant capacity (TAC) has received attention as a useful tool for predicting total antioxidant power in the diet and it may be a novel predictor of major health outcomes as they relate to oxidative stress and deserves investigation as a measure of diet quality considering its convenience and effectiveness in assessing antioxidant-rich dietary patterns. Thus, evaluated the associations between dietary TAC and traditional diet quality index scores (DQIS), such as Healthy Eating Index-2015 (HEI-2015), Alternative Healthy Eating Index-2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH), and all-cause mortality in 23,797 US adults using the NHANES 1988∼1994 and 1999∼2006. After theoretically calculating dietary TAC, we found that US adults with high dietary TAC had greater adherence to the DQIS including HEI-2015, AHEI-2010, aMED, and DASH and dietary TAC was inversely associated with all-cause mortality similar to DQIS. These findings suggest that dietary TAC might be a relatively valid predictor of all-cause mortality in the US population and further studies need to expand upon this investigation to assess disease-specific mortality among various populations.
임다희,김우기,이미기,허호진,Ock K. Chun,김대옥 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.6
This study evaluated total phenolics, total flavonoids, and antioxidant capacity of randomly selected regular and decaffeinated coffees commercially available in Korea and their protective effects in human hepatic epithelial HepG2 cell line against oxidative stress. All coffees tested exhibited potent antioxidant capacity in chemical systems and, consequently, significant protection of cells from oxidative stress in vitro in a dose-dependent manner. In particular, H2O2-induced apoptosis as evaluated by annexin V staining and flow cytometry was prevented by coffee extracts, resulting in the enhanced cell viability. Of interest, the content of total phenolics and flavonoids in coffees demonstrated a positive correlation with antioxidant capacity, indicating that the antioxidant capacity of coffees may be attributed to those phytochemicals. In accordance with previous studies, caffeoylquinic acid (CQA) and its derivatives including 3-CQA, 4-CQA, 5-CQA, 3,4-diCQA,3,5-diCQA, and 4,5-diCQA were identified as phenolic phytochemicals by a reversed-phase HPLC, with 5-CQA being a major component. Taken together, the present study demonstrated protective effects of regular and decaffeinated coffees on cells in vitro against overwhelming oxidative stress due to richness in phenolics, especially CQA and its derivatives. Coffees, regular or decaffeinated, may serve as a good source of health-beneficial phytochemicals in diet.
Ha, Kyungho,Kim, Kijoon,Chun, Ock K.,Joung, Hyojee,Song, YoonJu Nature Publishing Group UK 2018 European journal of clinical nutrition Vol.72 No.6
<P>Conclusions A high carbohydrate intake is associated with metabolic abnormalities. As Korean adults consume more carbohydrate than American adults, stronger associations of dietary carbohydrate with metabolic syndrome were observed. Thus, further studies are necessary to elucidate the underlying mechanisms of different contributors to developing metabolic disease in Western and Asian populations.</P>
Protective effects of polyphenols against endocrine disrupting chemicals
Matthew P. Madore,Junichi R. Sakaki,Ock K. Chun 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.8
Endocrine disrupting chemicals (EDCs) are aheterogenous group of compounds dispersed throughout theenvironment that possess the ability to alter endocrine systemfunction. While there are numerous routes of exposureto EDCs, the predominant source of many of these compoundsis diet, largely due to their widespread use in foodcontact materials. In recent years, there has been a surgeof research aimed at assessing exposure to EDCs, identifyingtheir health implications, and developing approaches tominimize the risks they may entail. Due to their antioxidantand anti-infl ammatory potential, polyphenols have beenpurported to confer protection against EDC-induced healthdetriments. This review discusses the evidence pertaining todietary exposure to the two predominant EDCs, bisphenol Aand phthalates, in the United States, their associations withdiabetes, cancer, and cardiovascular disease outcomes, thepotential for polyphenols to mitigate their disease-promotingeff ects, gaps in knowledge, and recommendations for futureresearch.
Briana M. Nosal,Junichi R. Sakaki,김대옥,Ock K. Chun 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.8
Although coffee has been reported as a major contributor to antioxidants in the diet, there are limited studies assessing how brewing methods and types of coffee affect antioxidant capacity of coffee consumers. This study was aimed to investigate the impact of coffee preparation on total phenolic content in brewed coffee extracts and their contribution to antioxidant status. We examined how the different brewing methods affect total phenolic content and antioxidant capacity in brewed coffee extracts, then assessed the antioxidant status of coffee consumers after drinking coffee. Results showed that consuming capsule versus French press coffee provides a higher total phenolic content and drinking capsule coffee leads to greater antioxidant status as shown by the higher total antioxidant capacity in urine. Further studies can expand on this by using a broader range of brewing methods to evaluate the contribution of brewing methods of coffee to antioxidant status.
Lithospermum erythrorhizon Extract Protects Keratinocytes and Fibroblasts Against Oxidative Stress
유희근,이봉한,김우기,이종석,김건희,Ock K. Chun,Sung I. Koo,김대옥 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11
Oxidative stress damages dermal and epidermal cells and degrades extracellular matrix proteins, such as collagen, ultimately leading to skin aging. The present study evaluated the potential protective effect of the aqueous methanolic extract obtained from Lithospermum erythrorhizon (LE) against oxidative stress, induced by H2O2 and ultraviolet (UV) irradiation, on human keratinocyte (HaCaT) and human dermal fibroblast–neonatal (HDF-n) cells. Exposure of cells to H2O2 or UVB irradiation markedly increased oxidative stress and reduced cell viability. However, pretreatment of cells with the LE extract not only increased cell viability (up to 84.5%), but also significantly decreased oxidative stress. Further, the LE extract downregulated the expression of matrix metalloproteinase-1, an endopeptidase that degrades extracellular matrix collagen. In contrast, treatment with the LE extract did not affect the expression of procollagen type 1 in HDF-n cells exposed to UVA irradiation. Thirteen phenolic compounds, including derivatives of shikonin and caffeic acid, were identified by ultrahigh-performance liquid chromatography–electrospray ionization–tandem mass spectrometry. These results suggest that LE-derived extracts may protect oxidative-stress-induced skin aging by inhibiting degradation of skin collagen, and that this protection may derive at least in part from the antioxidant phenolics present in these extracts. Further studies are warranted to determine the potential utility of LE-derived extracts in both therapeutic and cosmetic applications.
Xi Zheng,Sun-Kyeong Lee,Ock K. Chun 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.1
Osteoporosis is an age-related disorder that affects both women and men, although estrogen deficiency induced by menopause accelerates bone loss in older women. As the demographic shifts to a more aged population, a growing number of men and women will be afflicted with osteoporosis. Since the current drug therapies available have multiple side effects, including increased risk of developing certain types of cancer or complications, a search for potential nonpharmacologic alternative therapies for osteoporosis is of prime interest. Soy isoflavones (SI) have demonstrated potential bone-specific effects in a number of studies. This article provides a systematic review of studies on osteoporotic bone loss in relation to SI intake from diet or supplements to comprehensively explain how SI affect the modulation of bone remodeling. Evidence from epidemiologic studies supports that dietary SI attenuate menopause-induced osteoporotic bone loss by decreasing bone resorption and stimulating bone formation. Other studies have also illustrated that bone site-specific trophic and synergistic effects combined with exercise intervention might contribute to improve the bioavailability of SI or strengthen the bonespecific effects. To date, however, the effects of dietary SI on osteoporotic bone loss remain inconclusive, and study results vary from study to study. The current review will discuss the potential factors that result in the conflicting outcomes of these studies, including dosages, intervention materials, study duration, race, and genetic differences. Further well-designed studies are needed to fully understand the underlying mechanism and evaluate the effects of SI on osteoporosis in humans.