http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Nobuyuki Horie (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Kawamura, Satoshi,Horie, Nobuyuki,Okahashi, Noriko,Higuchi, Hashihiro Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.4
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made intermittent attempts to introduce in vitro assays as screening tests for developmental toxicity of inhouse candidate products. Two cell-based assays which were developed two decades apart were intensively studied. One was an assay of inhibitory effects on mouse ascites tumor cell attachment to a concanavalin A-coated plastic sheet surface (MOT assay), which we studied in the early days of assay development. The other was an assay of inhibitory effects on the differentiation of mouse embryonic stem cell to beating heart cells (EST assay), which we assessed more recently. We evaluated the suitability of the assays for screening in-house candidates. The concordance rates with in vivo developmental toxicity were at the 60% level. The EST assay classified chemicals that inhibited cell proliferation as embryo-toxic. Both assays had a significant false positive rate. The assays were generally considered unsuitable for screening the developmental toxicity of our candidate compounds. Recent test systems adopt advanced technologies. Despite such evolution of materials and methods, the concordance rates of the EST and MOT systems were similar. This may suggest that the fundamental predictivity of in vitro developmental toxicity assays has remained basically unchanged for decades. To improve their predictivity, in vitro developmental toxicity assays should be strictly based on elucidated pathogenetic mechanisms of developmental toxicity.
-
Satoshi Kawamura,Nobuyuki Horie,Noriko Okahashi,Hashihiro Higuchi 한국독성학회 2019 Toxicological Research Vol.35 No.4
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made intermittent attempts to introduce in vitro assays as screening tests for developmental toxicity of inhouse candidate products. Two cell-based assays which were developed two decades apart were intensively studied. One was an assay of inhibitory effects on mouse ascites tumor cell attachment to a concanavalin A-coated plastic sheet surface (MOT assay), which we studied in the early days of assay development. The other was an assay of inhibitory effects on the differentiation of mouse embryonic stem cell to beating heart cells (EST assay), which we assessed more recently. We evaluated the suitability of the assays for screening in-house candidates. The concordance rates with in vivo developmental toxicity were at the 60% level. The EST assay classified chemicals that inhibited cell proliferation as embryo-toxic. Both assays had a significant false positive rate. The assays were generally considered unsuitable for screening the developmental toxicity of our candidate compounds. Recent test systems adopt advanced technologies. Despite such evolution of materials and methods, the concordance rates of the EST and MOT systems were similar. This may suggest that the fundamental predictivity of in vitro developmental toxicity assays has remained basically unchanged for decades. To improve their predictivity, in vitro developmental toxicity assays should be strictly based on elucidated pathogenetic mechanisms of developmental toxicity.
-
Study on Quantitative Evaluation Methods of Therapeutic Effects of Sanding Training
Yoshifumi Morita,Ryota Tanioku,Tsubasa Horie,Masaki Uchida,Hiroyuki Ukai,Nobuyuki Matsui 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
In the future the final aims of our research are to quantitatively evaluate the therapeutic effect of upper limb motion during the training and to develop a new rehabilitation training support robot with the evaluation function. This paper presents new evaluation methods of therapeutic effect of a sanding training. The sanding training is one type of resistance training for upper limbs. Three methods to evaluate achievement level of sanding training, cooperative movement of healthy and disabled arms, and cooperative movement of forearm and upper arm are proposed. The validities of the proposed evaluation methods are examined using the measurement data of patients with hemiplegia. Moreover, the relationships between the evaluation results and the Brunnstrom Stage of the patients are examined.
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
