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Kang, Young Ji,Uchida, Masaki,Shin, Hyun-Hee,Douglas, Trevor,Kang, Sebyung Royal Society of Chemistry 2011 Soft matter Vol.7 No.23
<P>Genetically modified thermostable Pf_Fn was prepared and the magnetic FePt nanoparticles were biomimetically synthesized within it. Site specific chemical modifications of FePt mineralized Pf_Fn exterior surface and biotin–streptavidin interactions allow forming uniform layer-by layer assemblies. Similar approaches can be used for other functional nanomaterials and fabricating nanostructured functional materials.</P> <P>Graphic Abstract</P><P>FePt nanoparticles are biomimetically synthesized within thermostable Pf_Fn and the uniform layer-by-layer assemblies of FePt encapsulated protein cages are formed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1sm06319g'> </P>
Study on Quantitative Evaluation Methods of Therapeutic Effects of Sanding Training
Yoshifumi Morita,Ryota Tanioku,Tsubasa Horie,Masaki Uchida,Hiroyuki Ukai,Nobuyuki Matsui 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
In the future the final aims of our research are to quantitatively evaluate the therapeutic effect of upper limb motion during the training and to develop a new rehabilitation training support robot with the evaluation function. This paper presents new evaluation methods of therapeutic effect of a sanding training. The sanding training is one type of resistance training for upper limbs. Three methods to evaluate achievement level of sanding training, cooperative movement of healthy and disabled arms, and cooperative movement of forearm and upper arm are proposed. The validities of the proposed evaluation methods are examined using the measurement data of patients with hemiplegia. Moreover, the relationships between the evaluation results and the Brunnstrom Stage of the patients are examined.
( Kazutami Sakamoto ),( Yuji Yamashita ),( Hiroyasu Ohtaka ),( Yosuke Hashimoto ),( Masaki Takemura ),( Yoshikazu Uchida ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Trans-Urocanic acid (t-UCA) is recognized as an end metabolite of filaggrin via histidine which is a part of NMF amino acids in the stratum corneum (SC). As an intrinsic chromophore in SC under UV exposure, t-UCA converts to cis isomer (c-UCA) which initiates UV-induced immunosuppression. There are controversial discussions about c-UCA whether its immunosuppressive function is for the protection of body or rather to trigger carcinogenic reactions. Even though, existence of t-UCA in SC and conversion to c-UCA by UV radiation is real events evolved in Nature for the mammalian skin especially in human. The objective of this study is to investigate the transient isomerization of t-UCA in SC to c-UCA during the course of seasonal solar UV Index change in order to better understand the role of UCA for the skin physiology. Ten volunteers with age 21 to 34 are recruited and UCA isomer ratio was measured twice a week for six weeks (Sep 14th through Oct 19 in 2012). SC samples were tape stripped from the inner upper arm and UCA isomers are analyzed by HPLC. Average cis/trans ratio decreased gradually from c.a. 2.0 to 0.2. Solar UV Index reported for the area of experiment also decreased by the duration of days during the 6 weeks test period and there are good correlation found between isomer ratio and Solar UV Index. As a result, dynamic photo-isomerization of UCA in response to the solar UV radiation was confirmed. This finding would lead us further investigation of the functional roles of UCA in the skin especially for the Filaggrin mutation and Atopic Dermatitis, which is one of the hot topics in skin science.