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Oxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, Rakesh Kumar,Patel, Amit Kumar,Shah, Niranjan,Choudhary, Arun Kumar,Jha, Uday Kant,Yadav, Uday Chandra,Gupta, Pavan Kumar,Pakuwal, Uttam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Reactive oxygen species (ROS), highly reactive molecules, are produced by living organisms as a result of normal cellular metabolism and environmental factors, and can damage nucleic acids and proteins, thereby altering their functions. The human body has several mechanisms to counteract oxidative stress by producing antioxidants. A shift in the balance between oxidants and antioxidants in favor of oxidants is termed as "oxidative stress". Paradoxically, there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). This review also deals with classification as well as mechanisms of formation of free radicals, examining their beneficial and deleterious effects on cellular activities and focusing on the potential role of antioxidants in preventing and repairing damage caused by oxidative stress. A discussion of the role of phytochemical antioxidants in oxidative stress, disease and the epigenome is included.
( Niranjan Kumar ),( K. P. Singh ) 한국균학회 2011 Mycobiology Vol.39 No.2
A laboratory experiment was conducted to study the induction of constricting rings and test predation of Dactylaria brochopaga isolates against second stage juveniles (J2s) of Meloidogyne graminicola, Among the five fungal isolates, isolate D showed the greatest number of predatory rings and, consequently, trapped the maximum number of M. graminicola J2s in dual cultures. Another pot experiment was conducted to study the effect of D. brochopaga (isolate D) on the management of wheat root-knot disease. Applying a mass culture (10 g/pot) and a spore suspension of the fungus with and without cow dung manure to soil infested with 2,000 M. graminicola juveniles significantly improved plant height, root length, weights of shoots, roots, panicles and grains per hill compared to those in the control. Moreover, the fungus significantly reduced the number of root-knots, the number of egg masses, juveniles, and females per hill compared to those in the control. Bio-efficacy of the fungus was heightened when the mass culture and a spore suspensions were used in combination with cow dung manure to improve the plant growth parameters and reduce the number of root-knot and reproductive factors. Further investigations should be conducted to identify the impact of this fungus in the field.
Purification, Characterization, and Biochemical Properties of α-Amylase from Potato
( Goutam Kumar Sarker ),( Sohel Hasan ),( Farjana Nikkon ),( Ashik Mosaddik ),( Niranjan Kumar Sana ),( Habibur Rahman ),( Sang Gyu Park ),( Dong Sun Lee ),( Somi Kim Cho ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
Purification, characterization and biochemical properties of α-amylase from post harvest Bangladeshi Potato (Solanum tuberosum L.) were investigated. The α-amylase was purified by successive chromatography on DEAE and CM-cellulose columns with a yield of 24.24%. SDS-PAGE showed a molecular weight of 44 kDa for the enzyme that contain 2.8% sugar. The enzyme lost total activity in the presence of the chelating agent EDTA, confirming it was an α-type amylase. The enzyme displayed optimum activity at pH 7.2 and 37˚C, with an apparent Km value of 0.26% using starch as its substrate. The enzyme was strongly inhibited by Cu2+, Fe2+ and Zn2+; moderately by Li+, Hg+ and Cd2+; and slightly by Ag+, K+, Mn2+ and Mg2+. Conversely, Fe3+ and Na+ appreciably enhanced activity, while adding calcium ion nearly doubled enzyme activity. In addition, the activity of α-amylase gradually decreased with increasing concentrations of urea. Thus, potato α-amylase is an attractive target for study to better understand the structure-function relationships of α-amylases.
Biochemistry : Purification, Characterization, and Biochemical Properties of α-Amylase from Potato
Goutam Kumar Sarker,Sohel Hasan,Farjana Nikkon,Ashik Mosaddik,Niranjan Kumar Sana,Habibur Rahman,Sang Gyu Park,Dong Sun Lee,So Mi Kim Cho 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.1
Tripathy, Suman Kumar,De, Umasankar,Dehury, Niranjan,Laha, Paltan,Panda, Manas Kumar,Kim, Hyung Sik,Patra, Srikanta The Royal Society of Chemistry 2016 Dalton Transactions Vol.45 No.38
<P>Six mononuclear Ir complexes (1-6) using polypyridyl-pyrazine based ligands (L-1 and L-2) and {[cp*IrCl-(mu-Cl)](2) and [(ppy)(2)Ir(mu-Cl)](2)} precursors have been synthesised and characterised. Complexes 1-5 have shown potent anticancer activity against various human cancer cell lines (MCF-7, LNCap, Ishikawa, DU145, PC3 and SKOV3) while complex 6 is found to be inactive. Flow cytometry studies have established that cellular accumulation of the complexes lies in the order 2 > 1 > 5 > 4 > 3 > 6 which is in accordance with their observed cytotoxicity. No changes in the expression of the proteins like PARP, caspase 9 and beclin-1, Atg12 discard apoptosis and autophagy, respectively. Overexpression of CHOP, activation of MAPKs (P38, JNK, and ERK) and massive cytoplasmic vacuolisation collectively suggest a paraptotic mode of cell death induced by proteasomal dysfunction as well as endoplasmic reticulum and mitochondrial stress. An intimate relationship between p53, ROS production and extent of cell death has also been established using p53 wild, null and mutant type cancer cells.</P>
Purification, Characterization, and Biochemical Properties of $\alpha$-Amylase from Potato
Sarker, Goutam Kumar,Hasan, Sohel,Nikkon, Farjana,Mosaddik, Ashik,Sana, Niranjan Kumar,Rahman, Habibur,Park, Sang-Gyu,Lee, Dong-Sun,Cho, So-Mi Kim The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
Purification, characterization and biochemical properties of $\alpha$-amylase from post harvest Bangladeshi Potato (Solanum tuberosum L.) were investigated. The $\alpha$-amylase was purified by successive chromatography on DEAE and CM-cellulose columns with a yield of 24.24%. SDSPAGE showed a molecular weight of 44 kDa for the enzyme that contain 2.8% sugar. The enzyme lost total activity in the presence of the chelating agent EDTA, confirming it was an $\alpha$-type amylase. The enzyme displayed optimum activity at pH 7.2 and $37^{\circ}C$, with an apparent Km value of 0.26% using starch as its substrate. The enzyme was strongly inhibited by $Cu^{2+},\;Fe^{2+}$ and $Zn^{2+}$; moderately by $Li^+,\;Hg^+$ and $Cd^{2+}$; and slightly by $Ag^+,\;K^+,\;Mn^{2+}$ and $Mg^{2+}$. Conversely, $Fe%{3+}$ and $Na^+$ appreciably enhanced activity, while adding calcium ion nearly doubled enzyme activity. In addition, the activity of $\alpha$-amylase gradually decreased with increasing concentrations of urea. Thus, potato $\alpha$-amylase is an attractive target for study to better understand the structure-function relationships of $\alpha$-amylases.
Evolution of Insurance Sector: A Global Perspective
Niranjan Nayak,Rohita Kumar Mishra KINFORMS 2014 Management Review Vol.9 No.2
Insurance markets have changed radically in the last 20 years. There are some key developments in insurance as well as financial services market which has a greater impact on global scale. It influences globally with some constraints. The insurance marketing has become a vital part of some national as well as international market. The incremental development focuses on cultural, legal, institutional, and demographic consideration that impact the emerging global trends. The authors attempt to address the global similarities of national insurance market and the local contingencies that create differences among markets. The purpose here is to analyze the global insurance industry and to show the diversity of insurance market at large.
Tripathy, Suman Kumar,De, Umasankar,Dehury, Niranjan,Pal, Satyanarayan,Kim, Hyung Sik,Patra, Srikanta The Royal Society of Chemistry 2014 Dalton Transactions Vol.43 No.39
<P>Phpy bridged homodinuclear Ru–Ru (<B>1</B>) and heterodinuclear Ir–Ru complexes (<B>2</B>) have been developed. Complex <B>2</B> induces autophagy towards the cisplatin resistant human breast cancer (MCF7) cell line, whereas <B>1</B> is inactive.</P> <P>Graphic Abstract</P><P>Heterodinuclear Ir–Ru (<B>2</B>) with polypyridyl based phpy ligand shows autophagy induced cell death, whereas homodinuclear Ru–Ru (<B>1</B>) is inactive. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4dt01033g'> </P>