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RISS 인기검색어
- 검색키워드
- 저자 : Ning-Ning Dou (검색결과 4 건)
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Ning-Ning Dou,Hao-lin Wang,Shao-Zhen Hu,Zheng-Nan Huang,Jun Zhong,Shi-Ting Li 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: Although endoscopic drill has the advantages in manipulation and hemostasis, whose low efficiency and blurred vision reduce the efficacy of lumbar endoscopic unilateral laminotomy with bilateral decompression (LE-ULBD). The present study was designed to evaluate the safety and efficacy of full-visualized trephine/osteotome in the LE-ULBD surgery for severe lumbar stenosis. Methods: Fifty-seven severe lumbar stenosis patients who underwent LE-ULBD between January 2020 to January 2023 were enrolled, who were divided into drill and visualized trephine groups. The medical records including demographics, operative duration, intraoperative electrophysiological findings, postoperative hospital stay or hospital stay, postoperative outcomes and complications were retrospectively reviewed and analyzed. Results: A total of 57 patients included 15 in drill and 42 in trephine group were enrolled in the study. There was significant difference in the pre- and postoperative visual analogue scale and Oswestry Disability Index scores in both groups (p < 0.05). The mean operative duration in the trephine group (101.05 ± 12.18 minutes) was shorter than that in the drill group (134.67 ± 9.68 minutes) (p < 0.05). There was no statistical difference between the 2 groups in electrophysiological monitoring, posthospital stays, postoperative outcomes and complications. Abnormal free-electromyography (EMG) were recorded in 2 (13.3%) and 5 patients (11.9%) in the drill and trephine group. Intraoperative somatosensory evoked potential changes occurred in 3 (20%) and 3 patients (7.1%) in the drill and trephine group and all patients recovered immediately when surgery ended. No serious complications and recurrence occurred in all the patients. Conclusion: Full-visualized trephine/osteotome has been approved to be convenient, safe and efficient in our study, which combined with translaminar inside-out technique and EMG monitoring especially free-EMG may offer a new choice in LE-ULBD surgery for lumbar stenosis patients.
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Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling
( Ning Ding ),( Yanzhu Lu ),( Hanmin Cui ),( Qinyu Ma ),( Dongxia Qiu ),( Xueting Wei ),( Ce Dou ),( Ning Cao ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.3
We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor кB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKLevoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulindependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway. [BMB Reports 2020; 53(3): 154-159]
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EFFECT OF DIMENSIONS OF TEAM ATTACHMENT ON RUNNING GROUP IN SPORT EXERCISE
Ning (Chris) Chen,Jifang Dou,Xueli Wang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Over the past decade, the field of sport exercise in China gets increasingly popular, resulting in a nationwide exercise fashion (Schulenkorf, Sherry, & Rowe, 2016; Yu, Li, Liu, & Su, 2015). With this new emerging shift, this study tested the proposed structural model, and specifically tested the mediating effects of dimensions of sport team attachment between runners’ team satisfaction and their runner team building behaviors (Morhart, Herzog, & Tomczak, 2009). With a sample size of 301, three dimensions of team attachment, team identity, social bonding, and team expectation were found to be significant influencing runners’ in-role team building behavior and participation in the development of this runner team. Other important findings and implications were further discussed.
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