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Thu Hien Nguyen,Thi Thanh Ngan Nguyen,Bac Viet Le,Ngoc Minh Thanh,Thi Kim Lien Nguyen,Van Hai Nong,Huy Hoang Nguyen 한국유전학회 2017 Genes & Genomics Vol.39 No.3
Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders characterized by ritualistic- repetitive behaviors and impaired verbal and non-verbal communication. Boys are more likely to be diagnosed with ASD than girls. Genetics have been shown to play a key role in the etiology of autism. Many genes were found to be implicated in the inheritance of idiopathic autism. Analysis of mutation abnormalities associated with autism contributes significantly to the identification of autism candidate genes. Whole-exome sequencing has been shown as an application of the next generation sequencing technology used to determine the variations of all coding regions, or exons of the known genes. In the present study, we have found two novel heterozygous missense mutations (p.L111P and p.R3048C) on the RYR3 gene, which was located in the autism susceptibility region (15q14-q15) in a 9-year-old boy with ASD. Therefore, the sequence missense mutations provide the first suggestive link between a genetic abnormality in the RYR3 gene and a neurodevelopmental disorder.
Huong, Truong Thu,Bac, Ta Phuong,Thang, Bui Doan,Long, Dao Minh,Quang, Le Anh,Dan, Nguyen Minh,Hoang, Nguyen Viet International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.6
Since machine learning was invented, there have been many different machine learning-based algorithms, from shallow learning to deep learning models, that provide solutions to the classification tasks. But then it poses a problem in choosing a suitable classification algorithm that can improve the classification/detection efficiency for a certain network context. With that comes whether an algorithm provides good performance, why it works in some problems and not in others. In this paper, we present a data-centric analysis to provide a way for selecting a suitable classification algorithm. This data-centric approach is a new viewpoint in exploring relationships between classification performance and facts and figures of data sets.
The first years of liver transplantation: experiences at a single center
Phu Hong Pham,Nghia Phuoc Phan,Viet Doan Khac Tran,Viet Quoc Dang,Thuan Duc Nguyen,Long Cong Duy Tran,Bac Hoang Nguyen 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.2
Background: The aim of this study was to analyze the first stages of progress in liver transplantation (LT) at a single center in Vietnam. Methods: This study analyzed data from patients and donors who participated in the LT program between August 2018 and December 2021 at University Medical Center, Ho Chi Minh City. Study measures included any difficulties encountered, as well as the post- LT outcomes for living donor LT (LDLT) and deceased donor LT (DDLT). The chi-square test and Kaplan Meier survival analysis were used to test the factors that influenced the outcomes. Results: A total of 18 adult recipients with LT (LDLT, n=16; DDLT, n=2) were included (mean age, 55.2±2.6 years; male, 88.9%). The most common post-LT complications were middle hepatic venous stenosis (20%) and graft rejection (22.2%). These compli- cations were observed in LDLT patients. For DDLT, graft rejection (50%) was the only complication recorded. The survival rates for recipients at 3 months, 6 months, and 1 year were 100%, 88.9%, and 88.9%, respectively. The LDs had their right livers without the middle hepatic veins harvested, and biliary leakage (6.25%) was the only complica- tion observed. There were no deaths among recipients or LDs during the operations or hospital stays. Conclusions: This study provides key details about the process of LT, and these positive outcomes support LT as an important therapy for end-stage liver disease and early he- patocellular carcinomas.