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Son, Eun-Wha,Mo, Sung-Ji,Rhee, Dong-Kwon,Pyo, Suhk-Neung The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10
Interactions of the cell adhesion molecules are known to play important roles in mediating inflammation. The proinflammatory cytokine, tumor necrosis factor-${\alpha}$(TNF-${\alpha}$), activates the NF-kB signaling pathway, which induces the expression of various genes, such as intercellular adhesion molecule-1 (ICAM-1). In this study, the effect of vitamin C on the ICAM-1 expression induced by TNF-${\alpha}$ in a human neuroblastoma cell line, SK-N-SH was investigated. Treatment with vitamin C resulted in the downregulation of the TNF-${\alpha}$-induced surface expression and ICAM-1 mRNA levels in a concentration-dependent manner. Moreover, a gel shift analysis indicated that vitamin C dose-dependently inhibited the NF-kB activation and IkB${\alpha}$ degradation induced by TNF-${\alpha}$. Taken together, these results suggest that vitamin C downregulates TNF-${\alpha}$- induced ICAM-1 expression via the inhibition of NF-kB activation.
An investigation of the properties of Cu-Be-x alloys prepared by horizontal continuous casting
홍현선,Man Sik Kong,Neung-Mo Sung,Seung Yun Lee,Kyung Min Kim 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.3
The effects of the solid solution and aging treatment on the microstructure, hardness and electrical conductivity of Cu alloys containing 0.7 wt% and 1.8 wt% Be were investigated. These Cu-Be alloys contain Co, Si, Ni and Mn as alloying elements. An horizontal continuous casting process was applied to obtain unidirectionally solidified billets. A solid solution treatment of the sample was carried out at 865 oC and aging treatments were performed in the range 270-550 oC. For the Cu-1.8 wt% Be alloys, the electrical conductivity generally increased as the aging temperature increased in the range of 270-370 oC. For the Cu-0.7 wt% Be alloys, the electrical conductivity increased as the aging time increased in the range of 10-180 min. The effects of the solid solution and aging treatment on the microstructure, hardness and electrical conductivity of Cu alloys containing 0.7 wt% and 1.8 wt% Be were investigated. These Cu-Be alloys contain Co, Si, Ni and Mn as alloying elements. An horizontal continuous casting process was applied to obtain unidirectionally solidified billets. A solid solution treatment of the sample was carried out at 865 oC and aging treatments were performed in the range 270-550 oC. For the Cu-1.8 wt% Be alloys, the electrical conductivity generally increased as the aging temperature increased in the range of 270-370 oC. For the Cu-0.7 wt% Be alloys, the electrical conductivity increased as the aging time increased in the range of 10-180 min.