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( Nauman Arif Jadoon ),( Zeeshan Butt ),( Ahmed Shahzad ),( Kamran Mushtaq ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The objective of our study was to assess the impact of anemia on HE grade at presentation. Methods: Consecutive patients of HE admitted in the medical wards of Mayo Hospital, Lahore during March 2010 and May 2010 were enrolled in the study. HE grade at presentation was assessed by using West-Haven Criteria. Complete blood count, bleeding profile, liver function tests and ultrasound was done in emergency at presentation. Anemia was defined as hemoglobin level less than 12 g/dl. Univariate and multivariate logistic regression analysis was done to assess the impact of anemia on hepatic encephalopathy grade at presentation. P value <0.05 was considered significant. Results: 61 patients were included in the study. 20% patients were in grade 1 HE; 20% in grade 2; 39% in grade 3; and 21% in grade 4 HE. Advanced grade HE was defined as HE grade >2. On univariate analysis prothrombin time >15 seconds, diabetes, esophageal varices on endoscopy, and anemia were significant predictors of advanced grade HE (p values: 0.048, 0.048, 0.039, 0.037). Hypoalbuminemia was less common in advanced grade HE patients (p, 0.004). Child Pugh Score and MELD Score had no relation with HE grade at presentation. All the significant factors in univariate analysis were included in the multivariate logistic regression model. Only anemia was significant predictor of advanced grade HE in multivariate analysis (p, 0.018). Conclusions: Sixty percent of HE patients present with advanced grade. Anemia is associated with advanced HE grade at presentation.
PE-107: Hyponatremia in Decompens ated Cirrhosis: Is It Associated with More Severe Disease?
( Nauman Arif Jadoon ),( Zeeshan Butt ),( Ahmed Shahzad ),( Kamran Mushtaq ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The aim of our study was to evaluate whether there is any association between hyponatremia and severity of decompensated cirrhosis. Methods: Consecutive patients of decompensated cirrhosis presenting at three tertiary care hospitals were included in the study. Hyponatremia was defined as serum sodium levels of <135 mEq/L. Patients with Child-Pugh Class A and B were considered having mild disease and Class C patients were categorized as having severe disease. Results: A total of 202 patients were included in the study with male preponderance (53%). Patients presenting with Child-Pugh Class A, B and C were 16 (6.9%), 74 (36.6%) and 114 (56.4%) respectively. Hyponatremia was present in 37.3% of the patients. On bivariate analysis, factors associated with severe decompensated cirrhosis (Child-Pugh Class C) were total protein <6 g/dL (p, 0.002), hemoglobin level <12 g/dL (p, 0.006), APTT >35 seconds (p <0.001), AST >35 IU (p, 0.03) and serum sodium level <135 mEq/L. Thrombocytopenia, raised blood urea, raised serum creatinine, and hyperkalemia were not associated with severity of decompensated cirrhosis as was the etiology of cirrhosis (Hepatitis C versus non-hepatisis C). Variables significant in the bivariate analysis were then included in the multivariate logistic regression model. All the variables remained significant except anemia which did not show any association with severity of disease in multivariate analysis. Conclusions: One third of the patients with decompensated cirrhosis in the present study had hyponatremia which was associated with less severe disease (lower Child-Pugh Class) at presentation.
Ahmad, Nazir,Ahmed, Iftikhar,Shahzad, Armghan,Khalid, Nauman,Mehboob, Farrakh,Ahad, Karam,Ali, Ghulam Muhammad The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.3
Phenol is a toxic pollutant found in effluent of numerous industries and its elimination is a foremost challenge. The utilization of bacteria plays a crucial role in phenol bioremediation. For isolation of phenol degrading bacteria, sample was collected from industrial waste and enriched in mineral salt medium (MSM) contained 300 mg/L phenol. The strain was identified based on 16S rRNA gene analysis as Pseudomonas species and the phylogenetic analysis affiliated the strain with Pseudomonas monteilii (AF064458) as the most closely related species. Phenol tolerance of the strain in MSM supplemented with various concentrations of phenol indicates that the strain NCCP-407 can grow best at $750mgL^{-1}$ phenol. The strain showed complete degradation of $750mgL^{-1}$ phenol in 56 hours when supplement as a sole source of carbon and energy with the average degradation rate of $28mgL^{-1}h^{-1}$. The doubling time was recorded approximately as $12.49h^{-1}$. The present study suggests that this strain is efficient in phenol degradation and can be used in treatment of wastewater containing phenol.
Nazir Ahmad,Iftikhar Ahmed,Armghan Shahzad,Nauman Khalid,Farrakh Mehboob,Karam Ahad,Ghulam Muhammad Ali 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.3
Phenol is a toxic pollutant found in effluent ofnumerous industries and its elimination is a foremost challenge. The utilization of bacteria plays a crucial role in phenol bioremediation. For isolation of phenol degrading bacteria, sample was collectedfrom industrial waste and enriched in mineral salt medium (MSM)contained 300 mg/L phenol. The strain was identified based on16S rRNA gene analysis as Pseudomonas species and thephylogenetic analysis affiliated the strain with Pseudomonasmonteilii (AF064458) as the most closely related species. Phenoltolerance of the strain in MSM supplemented with variousconcentrations of phenol indicates that the strain NCCP-407 cangrow best at 750 mg L−1 phenol. The strain showed completedegradation of 750 mg L−1 phenol in 56 hours when supplementas a sole source of carbon and energy with the average degradationrate of 28mg L−1 h−1. The doubling time was recorded approximatelyas 12.49 h−1. The present study suggests that this strain is efficientin phenol degradation and can be used in treatment of wastewatercontaining phenol.