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RISS 인기검색어
- 검색키워드
- 저자 : Nackmoon Sung (검색결과 5 건)
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Identification of proteins of potential diagnostic value for bovine paratuberculosis
Cho, Donghee,Sung, Nackmoon,Collins, Michael T. WILEY-VCH Verlag 2006 Proteomics Vol.6 No.21
<P>Previously we showed that Mycobacterium paratuberculosis culture filtrates (CFs) contain more antigens that react with sera from infected cattle than do cellular extracts of the organism. The goal of the present study was to identify proteins of potential diagnostic value among these CF proteins. Proteins of potential interest were first separated by 2-DE. Roughly 240 CF protein spots were detected on CBB-stained gels using Phoretix 2D software. Of these, 83% reacted with serum from M. paratuberculosis-infected cattle in immunoblots. When bovine serum was absorbed with M. phlei antigens, however, only 37 of these antigenic protein spots were reactive. Twenty-four of these spots were selected for identification based on their immunoblot staining intensity and differences in pI and mass. A total of 14 proteins were ultimately identified by MS and BLAST searches as ModD, PepA, ArgJ, CobT, Antigen 85C, and nine hypothetical proteins. N-terminal peptide analysis of PepA, Antigen 85C, ModD, MAP1693c, MAP2168c, and MAP1022c showed that each protein has 27–39 amino acids that may function as a signal sequence suggesting they are secreted through a Sec-dependent pathway. These 14 proteins from M. paratuberculosis CF are strong candidates for use as antigens for improved serodiagnostic tests for bovine paratuberculosis.</P>
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Kyunghee Jung-Choi,Nackmoon Sung,Sun Hwa Lee,Misun Chang,Hee Jung Choi,Chung-Jong Kim,Nam-Kyong Choi,Hanna Kim,Yi-Jun Kim,Whanhee Lee,Hyesook Park,Eunhee Ha Ewha Womans University School of Medicine 2022 EMJ (Ewha medical journal) Vol.45 No.4
In response to the changes in the Coronavirus disease 2019 (COVID-19) epidemic situation, Ewha Womans University established Ewha Safe Campus (ESC), an on-campus infection outbreak management system, to allow students and faculty members to safely resume face-to face classes in 2022. The COVID-19 testing station, Ewha Safe Station, is the core element of ESC. Symptomatic students and faculty members perform a combo swab self-PCR test or receive a nasopharyngeal swab PCR test from experts to prevent the spread of COVID-19 through early detection and management. ESC is significant in that it detects infection risks and proactively implements preemptive measures in a university. The COVID-19 health response system model at the university level was applied for the first time in South Korea, reaching a milestone in the history of university health in South Korea. In particular, it is highly valuable that the test was free of charge, as it enabled all of the examinees to have easy access to the test through joint cooperation with the Seegene Medical Foundation. This is a successful example of cooperation between schools and private institutions for public health improvement. In the future, the direct and indirect effects of the establishment and implementation of ESC need to be evaluated and confirmed, and areas requiring improvements need to be identified in preparation for another infectious disease outbreak in the future.
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A new strategy for tuberculosis control in North Korea
Young-jeon Shin,Moran Ki,Nackmoon Sung 한국역학회 2015 Epidemiology and Health Vol.37 No.-
Tuberculosis is one of the most prevalent diseases in North Korea. Despite some positive accomplishments by current aid projects, it is still necessary to investigate the existing aid system. The following are necessary for improvement: sustaining a high degree of expertise, cooperation among various related parties including the international community, mediation to induce this cooperation, a more active role of the South Korean government, and encouragement of North Korea to more actively participate. Achieving these will help solve the issues of current tuberculosis aid projects in North Korea and lead to more successful outcomes.
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Whanhee Lee,Kyunghee Jung-Choi,Hyunjin Park,Seunghee Jun,Nackmoon Sung,Sun-Hwa Lee,Misun Chang,Hee Jung Cho,Chung-Jong Kim,Hyesook Park,Eunhee Ha Ewha Womans University School of Medicine 2023 EMJ (Ewha medical journal) Vol.46 No.3
Objectives: Ewha Womans University launched an on-campus Coronavirus disease-19 (COVID-19) response system called Ewha Safety Campus (ESC) Project in collaboration with the Seegene Inc. RTPCR diagnostic tests for COVID-19 were proactively provided to the participants. This study examines the effectiveness of the on-campus testing strategy in controlling the reproduction number (R t) and identifying student groups vulnerable to infection. Methods: The ESC project was launched on March 2, 2022, with a pilot period from Feb 22 to March 1, 2022—the peak of the Omicron variant wave. We collected daily data on the RT-PCR test results of the students of Ewha Womans University from Mar 2 to Apr 30, 2022. We daily calculated R t and compared it with that of the general population of Korea (women, people aged 20–29 years, and Seoul residents). We also examined the students vulnerable to the infection based on the group-specific R t and positivity rate. Results: A lower R t was observed about 2 weeks after the implementation of the ESC Project than that of the general population. The lower R t persisted during the entire study period. Dormitory residents had a higher R t. The positivity rate was higher in students who did not comply with quarantine guidelines and did not receive the second dose of the vaccine. Conclusion: The study provides scientific evidence for the effectiveness of the on-campus testing strategy and different infection vulnerabilities of students, depending on dormitory residence, compliance with the quarantine guidelines, and vaccination.
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MTB-DR-RIF 9G membrane: a platform for multiplex SNP detection of multidrug-resistant TB.
Sayyed, Danishmalik Rafiq,Nimse, Satish Balasaheb,Song, Keum-Soo,Sung, Nackmoon,Kim, Taisun Springer-Verlag 2015 Analytical and Bioanalytical Chemistry Vol.407 No.19
<P>The MTB-DR-RIF 9G membrane can detect by detecting multiple mutations in multiple codons. The MTB-DR-RIF 9G membrane possesses clinical applicability in point-of-care settings for the following reasons: (i) 100% similar results with that of the sequencing analysis for clinical samples, (ii) discrimination of the multiple mutations in multiple codons, (iii) a specific/non-specific hybridization ratio higher than 350:1, and (iv) the sensitivity was found to be 1-10 copies/test for detection and discrimination of the wild and mutant TB strains. Graphical abstract Schematic illustration of the effect of controller DNA on the hybridization of the immobilized probes (corresponding to the wild TB strain) with the PCR product of (a) wild TB strain and (b) mutant TB strain.</P>
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