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( Norihiro Imai ),( Kenji Ikeda ),( Yuya Seko ),( Yusuke Kawamura ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Norio Akuta ),( Masahiro Kobayashi ),( Satoshi Saitoh ),( Fumitaka Suzuki ),( Yoshiyuki Suzuk 대한간학회 2013 Gut and Liver Vol.7 No.2
Miriplatin is a novel lipophilic platinum complex that was developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, little prospective data are available regarding the clinical toxicity of chemotherapeutic agents used to treat HCC patients with chronic renal failure. In a phase II study, the plasma concentration of total platinum in patients who received miriplatin was very low, and no severe renal toxicity caused by miriplatin injection was reported. Here, we present three cases of HCC with stage 4 chronic renal failure who received transcatheter arterial chemotherapy with miriplatin. All cases were male, ages 72, 84, and 83 years, and had serum creatinine levels of 2.3, 1.6, and 1.9 mg/dL, respectively. Their estimated glomerular filtration rates were 21.9, 20.3, and 22.2 mL/min, respectively. All cases were treated for unresectable HCC with transcatheter arterial chemotherapy with miriplatin. No serious adverse events were observed, and serum creatinine levels did not elevate, even in the patient who experienced renal failure caused by cisplatin administration. These results might suggest that transcatheter arterial chemotherapy with miriplatin can be safely used in HCC patients with chronic renal failure. (Gut Liver 2013;7:246-251)
( Yusuke Kawamura ),( Kenji Ikeda ),( Taito Fukushima ),( Yuya Seko ),( Tasuku Hara ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Norio Akuta ),( Masahiro Kobayashi ),( Satoshi Saitoh ),( Fumitaka Suzuki ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion thera-py for hepatocellular carcinoma (HCC). Methods: We divided 13 HCC patients into the following three groups: group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gela-tin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes. Results: The mean free cisplatin concentrations were as fol-lows. For group A, the mean was 48.58 μg/mL at 0 minute, 7.31 mL at 5 minutes, 5.70 mL at 10 minutes, and 7.15 mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 μg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C. Conclusions: These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver. (Gut Liver 2013;7:576-584)
AKARI-FIS POINT SOURCE CATALOGUE: CURRENT STATUS AND FUTURE PLAN
Yamamura, Issei,Makiuti, Sin'itirou,Ikeda, Norio,Koga, Tatsuya,Yoshino, Akira,Yamauchi, Chisato The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
The current status of the AKARI-FIS Point Source Catalogue is reported. The first version of the Bright Source Catalogue has been in public since March 2010 and used extensively in the various fields in astronomy. The second version of the Bright Source Catalogue and the first version of the Faint Source Catalogue are currently under development. The revised Bright Source Catalogue is expected to have improved completeness, reliability, and accuracy compared to the current version. The Faint Source Catalogue will have a scan-density dependent detection limit and will enable much deeper exploration of the sky especially in the high-ecliptic latitude regions. Both catalogues will be available in a year time scale.
( Tatsuya Hayashi ),( Satoshi Saitoh ),( Kei Fukuzawa ),( Yoshinori Tsuji ),( Junji Takahashi ),( Yusuke Kawamura ),( Norio Akuta ),( Masahiro Kobayashi ),( Kenji Ikeda ),( Takeshi Fujii ),( Tosiaki M 대한간학회 2017 Gut and Liver Vol.11 No.5
Background/Aims: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the he-patic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in patients with NAFLD. Methods: A total of 130 patients who were diagnosed with NAFLD and underwent Gd-EOB-DTPA-enhanced MRI were retrospectively included. Histological data were available for 118 patients. Hepatic volumetric parameters, including the left hepatic lobe to right hepatic lobe volume ratio (L/R ratio), were measured. The usefulness of the L/R ratio for diag-nosing fibrosis ≥F3-4 and F4 was assessed using the area under the receiver operating characteristic (AUROC) curve. Multiple regression analysis was performed to identify vari-ables (age, body mass index, serum fibrosis markers, and histological features) that were associated with the L/R ratio. Results: The L/R ratio demonstrated good performance in differentiating advanced fibrosis (AUROC, 0.80; 95% confi-dence interval, 0.72 to 0.88) from cirrhosis (AUROC, 0.87; 95% confidence interval, 0.75 to 0.99). Multiple regression analysis showed that only fibrosis was significantly associat-ed with the L/R ratio (coefficient, 0.121; p<0.0001). Conclu-sions: The L/R ratio, which is not influenced by pathologi-cal parameters other than fibrosis, is useful for diagnosing cirrhosis in patients with NAFLD. (Gut Liver 2017;11:674- 683)
AKARI FAR-INFRARED ALL-SKY SURVEY MAPS
Doi, Yasuo,Komugi, Shinya,Kawada, Mitsunobu,Takita, Satoshi,Arimatsu, Ko,Ikeda, Norio,Kato, Daisuke,Kitamura, Yoshimi,Nakagawa, Takao,Ootsubo, Takafumi,Morishima, Takahiro,Hattori, Makoto,Tanaka, Masa The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
Far-infrared observations provide crucial data for the investigation and characterisation of the properties of dusty material in the Interstellar Medium (ISM), since most of its energy is emitted between ~ 100 and $200{\mu}m$. We present the first all-sky image from a sensitive all-sky survey using the Japanese AKARI satellite, in the wavelength range $50-180{\mu}m$. Covering > 99% of the sky in four photometric bands with four filters centred at $65{\mu}m$, $90{\mu}m$, $140{\mu}m$, and $160{\mu}m$ wavelengths, this achieved spatial resolutions from 1 to 2 arcmin and a detection limit of < 10 MJy $sr^{-1}$, with absolute and relative photometric accuracies of < 20%. All-sky images of the Galactic dust continuum emission enable astronomers to map the large-scale distribution of the diffuse ISM cirrus, to study its thermal dust temperature, emissivity and column density, and to measure the interaction of the Galactic radiation field and embedded objects with the surrounding ISM. In addition to the point source population of stars, protostars, star-forming regions, and galaxies, the high Galactic latitude sky is shown to be covered with a diffuse filamentary-web of dusty emission that traces the potential sites of high latitude star formation. We show that the temperature of dust particles in thermal equilibrium with the ambient interstellar radiation field can be estimated by using $90{\mu}m$, $140{\mu}m$, and $160{\mu}m$ data. The FIR AKARI full-sky maps provide a rich new data set within which astronomers can investigate the distribution of interstellar matter throughout our Galaxy, and beyond.
THE FILAMENTARY WEB OF STAR FORMATION
White, Glenn J.,Doi, Yasuo,Komugi, Shinya,Kawada, Mitsunobu,Takita, Satoshi,Arimatsu, Ko,Ikeda, Norio,Kato, Daisuke,Kitamura, Yoshimi,Nakagawa, Takao,Ootsubo, Takafumi,Morishima, Takahiro,Hattori, Mak The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
Following the first Public Release of the AKARI Point Source catalogues, we have worked on the production of a new far-infrared All-Sky Diffuse mapping product. In this paper we report first results from the All Sky diffuse maps that will shortly be released to the community, based on analysis of data from the Far Infrared Surveyor ($65{\mu}m-160{\mu}m$) instrument. These data are likely to have a strong impact on studies of extended structures, and the diffuse ISM.
ADVANTAGES OF THE AKARI FIR ALL-SKY MAPS
YASUO DOI,SATOSHI TAKITA,TAKAFUMI OOTSUBO,KO ARIMATSU,MASAHIRO TANAKA,TAKAHIRO MORISHIMA,MITSUNOBU KAWADA,SHUJI MATSUURA,YOSHIMI KITAMURA,MAKOTO HATTORI,TAKAO NAKAGAWA,GLENN WHITE,NORIO IKEDA 한국천문학회 2017 天文學論叢 Vol.32 No.1
We present the {\it AKARI} far-infrared (FIR) all-sky maps and describe its characteristics, calibration accuracy and scientific capabilities. The {\it AKARI} FIR survey has covered 97\% of the whole sky in four photometric bands, which cover continuously 50--180 micron with band central wavelengths of 65, 90, 140, and 160 microns. The data have been publicly released in 2014 \citep{2015PASJ...67...50D} with improved data quality that have been achieved since the last internal data release \citep{2012PKAS...27..111D}. The accuracy of the absolute intensity is $\leq10$\% for the brighter regions. Quantitative analysis of the relative intensity accuracy and its dependence upon spatial scan numbers has been carried out. The data for the first time reveal the whole sky distribution ofinterstellar matter with arcminute-scale spatial resolutions at the peakof dust continuum emission, enabling us to investigate large-scaledistribution of interstellar medium in great detail. The filamentarystructure covering the whole sky is well traced by the all-sky maps. We describe advantages of the AKARI FIR all-sky maps for the study of interstellar matter comparing to other observational data.