Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Apem Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria.Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria.Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (<i>p</i>=0.01). A weak correlation was found between ACR and daytime DBP SDS (<i>r</i>=0.29, <i>p</i><0.001 and nighttime DBP SDS (<i>r</i>=0.21, <i>p</i>=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria.Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria. Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria. Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (P=0.01). A weak correlation was found between ACR and daytime DBP SDS (r=0.29, P<0.001 and nighttime DBP SDS (r=0.21, P=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria. Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Low-cost and low-technology oriented improvement of visual environment at intersections by ergonomic installation of traffic convex mirrors for preventive safety against crossing collisions

Mori Mori,Sadao Horino,Yuji Inomata,Hiroki Sasayama,Yuko Hirota 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-

In Japan, Quarter-million crossing collisions at intersections accounted for one-fourth of the total accidents in 2005. Three-fourths of collisions took place at urban intersections, more than half of them occurred at uncontrolled intersections. Risks of crossing collisions depend on the quality of visual environment at intersection. This study aimed to assess the legibility and effectiveness of 23 traffic convex mirrors installed at 10 urban intersections, after the road management authority inspected and repaired. The legibility of mirror was assessed by means of the photographs of each mirror taken from the drivers’ viewpoint at a legal stop line, entering from the lower priority direction. “Three ergonomics requirements” suggested by the authors were used as the criteria of legibility assessment; (1) Position of road lane, (2) Blind area and (3) Road surface markings. Combining these 3 criteria, the comprehensive assessment of mirror was indicated in 2-grade scale, such as “Good” or “Poor”, namely so dangerous to be improved. A field assessment revealed that 11 among 23 mirrors were still improperly installed. However, simulation analysis showed that 7 among 11 poor mirrors could be improved by adjusting the angle of mirror plate or displacing mirror plate/poles. In conclusion, the present official guideline in regard with installing mirror should be revised to add newly “three ergonomics requirements” for preventive safety. Application of these new guidelines in practice, a typical low-cost and low technology-oriented improvement to reduce crossing collisions, was highly recommended.

Insect-produced Elicitors, Fatty Acid Amino Acid Conjugates:Insights from Physiological Point of View

Naoki Mori,Naoko Yoshinaga 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

Fatty acid-amino acid conjugates (FACs), first identified from beet armyworm Spodoptera exigua larvae (Alborn et al., 1997), have been found in noctuid as well as sphingid caterpillar oral secretions and especially volicitin [N-(17-hydroxylinolenoyl)- L-glutamine, 17OH-volicitn] and its biochemical precursor, N-linolenoyl- L-glutamine, are known elicitors of induced volatile emissions in corn plants. We conducted FAC screening of 29 lepidopteran species and found FACs in 19 of these species (Yoshinaga & Mori et al., 2010). Thus, FACs are quite commonly synthesized through a broad range of lepidopteran caterpillars. From an evolutionary perspective, it is presumed that volicitin and the other FACs, although consequently unfavorable to the insect in the plant-herbivore interactions, are produced because they are essential part of the primary metabolism of the insects. In this context, we suggested that FACs in Spodoptera litura play an active role in nitrogen assimilation by regulating the amount of glutamine in the larval midgut (Yoshinaga & Mori et al., 2008). The benefits of the physiological function of FACs for the herbivores need to outweigh the costs caused by induction of plant defense

Crop improvement : Original Paper ; Expression of an enhancin gene from the Trichoplusia ni granulosis virus confers resistance to Lepidopterous insect pests to rice

( Mari Mori ),( Harushige Kitamura ),( Atsushi Kondo ),( Koji Dohi ),( Masashi Mori ),( Masanori Kaido ),( Kazuyuki Mise ),( Eiichi Shimojyo ),( Yoshifumi Hashimoto ) 한국식물생명공학회 ( 구 한국식물조직배양학회 ) 2006 Plant Biotechnology Vol.23 No.1

Effect of a dynamic absorber on friction-induced vibration of a rectangular plate

Hiroki Mori,Oleksandr Mikhyeyev,Takuo Nagamine,Mizue Mori,Yuichi Sato 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

When a plate-like object is rubbed by rubber, friction-induced vibration is generated. To reduce the friction-induced vibration, we experimentally investigate the characteristics of the vibration of a rectangular glass plate. The results show that the frequency of the frictioninduced vibration is almost the same as the natural frequency of a glass plate. The vibration is generated when the natural frequency of a rubbing system is close to that of a glass plate. We then examine the effect of a dynamic absorber mounted on the glass plate. The results demonstrate that the damping of a dynamic absorber is effective for suppressing the friction-induced vibration. Numerical simulation is also performed using a simplified analytical model. The calculated results agree qualitatively with the experimental ones.

A synthesis method of gene networks based on gene expression by network learning

Yoshihiro Mori,Yasuaki Kuroe,Takehiro Mori 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

5,20-Bis(α-oligothienyl)-substituted [26]hexaphyrins possessing electronic circuits strongly perturbed by <i>meso</i> -oligothienyl substituents

Mori, Hirotaka,Suzuki, Masaaki,Kim, Woojae,Lim, Jong Min,Kim, Dongho,Osuka, Atsuhiro Royal Society of Chemistry 2015 Chemical science Vol.6 No.3

<▼1><P>A series of [26]hexaphyrins(1.1.1.1.1.1) bearing two α-oligothienyl substituents at 5,20-positions have been synthesised and are shown to have a dumbbell hexaphyrin conformation, to which the α-oligothienyl groups are linked to form an acyclic helix-like conjugated network.</P></▼1><▼2><P>A series of [26]hexaphyrins(1.1.1.1.1.1) bearing two α-oligothienyl substituents at 5,20-positions have been synthesised and are shown to have a dumbbell hexaphyrin conformation, to which the α-oligothienyl groups are linked with small dihedral angles to form an acyclic helix-like conjugated network. While their distinct diatropic ring currents and four reversible reduction waves characteristic of aromatic [26]hexaphyrins indicate that the [26]hexaphyrin aromatic circuits are viable, the absorption spectra and excited state dynamics are significantly perturbed, which becomes increasingly evident with elongation of the oligothienyl substituents. DFT calculations of these hexaphyrins indicated that the LUMO and LUMO + 1 are localised on the hexaphyrin circuit and the HOMO and HOMO – 1 are spread over the acyclic helix-like conjugation network, which can explain the perturbed absorption spectra.</P></▼2>

Advances in Hospice and Palliative Care in Japan: A Review Paper

Mori, Masanori,Morita, Tatsuya Korean Society for Hospice and Palliative Care 2016 한국호스피스.완화의료학회지 Vol.19 No.4

Over the past decade, hospice and palliative care in Japan have progressed rapidly under the national policies supported by the Cancer Control Act. The numbers of palliative care units/inpatient hospices, hospital palliative care teams, and clinics with a home hospice function have been steadily increasing. The increasing numbers of physicians, nurses, and pharmacists have been certified as specialists in palliative care by national associations. Collaborative efforts have been made to standardize and disseminate educational programs and training opportunities in undergraduate, postgraduate, and continuing medical education. Research activities in Japan have markedly contributed to the growing body of evidence, especially in the fields of terminal delirium, terminal dehydration, palliative sedation, care for dying patients, prognostication, communication, psycho-oncology, and regional palliative care programs. This review focuses on major palliative care settings, specialty, national associations, education, and research in palliative care in Japan. 지난 10년 동안 암 관리법에 의한 국가 정책에 따라 일본에서는 호스피스 및 완화의료가 급속히 발전해왔다. 완화의료 시설 및 입원 환자의 호스피스, 병원의 완화 의료팀, 가정 호스피스 기능을 갖춘 진료소의 수는 꾸준히 증가하고 있으며 국가 협회로부터 완화의료 전문가로 공인된 의사, 간호사, 약사의 수도 증가하고 있다. 학부, 대학원 및 계속적인 의학 교육을 통해서 교육프로그램 및 교육의 기회를 표준화하고 보급하기 위한 공동 노력이 이루어졌다. 일본의 연구 활동은 말기 섬망, 말기 탈수증, 완화적 진정, 임종 환자의 의료, 예후, 의사 소통, 정신 종양학, 지역적인 완화의료 프로그램의 분야에서 현저하게 기여하였다. 이 보고서에서는 일본에서의 주요 완화의료 환경, 특성, 국가 협회, 교육, 완화의료 연구에 초점을 맞추었다.

Eco-car Manufacturing Activities as Engineering Design Education Subject in Suzuka National College of Technology

Mori, Kunihiko,Sakamoto, Hidetoshi,Ohbuchi, Yoshifumi Korean Society for Engineering Education 2012 공학교육연구 Vol.15 No.5

"The engineering education program for environmental intention and value creation" has been executed from 2008 to 2010 in Suzuka National College of Technology, which program was promoted as "Good Practice for Education" by Ministry of Education, Culture, Sports, Science and Technology Japan. "Eco-car project" is one of these practical ecology/environment education programs. The project's members have been learning and researching the environmental managements by the process of design, manufacturing, and assembly of solar car, highly effective fuel consumption car (Eco-run car), electric vehicle and fuel-cell car. Also this project was supported by some professional experts of the local industries and community. The students learned the actual industrial technique, the engineering management and the structure of local industries by this project. In this paper, the environmental intention engineering design education with local industry collaboration is introduced.