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Rapid transition from continental breakup to igneous oceanic crust in the South China Sea
Larsen, H. C.,Mohn, G.,Nirrengarten, M.,Sun, Z.,Stock, J.,Jian, Z.,Klaus, A.,Alvarez-Zarikian, C. A.,Boaga, J.,Bowden, S. A.,Briais, A.,Chen, Y.,Cukur, D.,Dadd, K.,Ding, W.,Dorais, M.,Ferré,, E. Nature Publishing Group 2018 Nature geoscience Vol.11 No.10
Torres, Gonzalo E.,Yao, Wei-Dong,Mohn, Amy R.,Quan, Hui,Kim, Kyeong-Man,Levey, Allan I.,Staudinger, Jeff,Caron, Marc G. 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
PDZ domain-containing proteins play an important role in the targeting and localization of synaptic membrane proteins. Here, we report an interaction between the PDZ domain-containing protein PICK1 and monoamine neurotransmitter transporters in vitro and in vivo. In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex. Coexpression of PICK1 with DAT in mammalian cells and neurons in culture results in colocalization of the two proteins in a cluster pattern and an enhancement of DAT uptake activity through an increase in the number of plasma membrane DAT. Deletion of the PDZ binding site at the carboxyl terminus of DAT abolishes its association with PICK1 and impairs the localization of the transporter in neurons. These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters.
Services of Algae to the Environment
CHAND, RAI, LAL,KUMAR, HAR DARSHAN,MOHN, FRIEDER HELMUT,SOEDER, CARL JOHANNAS 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.2
Being autotrophic, algae occupy a strategic place in the biosphere. They produce oxygen both directly and indirectly through the chloroplasts of all green plants. The chloroplasts are believed to have originated from archaic prokaryotic algae through endosymbiosis with primitive eukaryotic cells. Phytoplankton and other algae regulate the global environment not only by releasing oxygen but also by fixing carbon dioxide. They affect water quality, help in the treatment of sewage, and produce biomass. They can be used to produce hydrogen which is a clean fuel, and biodiesel, and fix N_2 for use as a biofertilizer. Some other services of algae to the environment include restoration of metal damaged ecosystems, reducing the atmospheric CO_2 load and mitigating global warming, reclamation of saline-alkaline unfertile lands, and production of dimethyl sulphide (DMS) and oxides of nitrogen (NOx) involved in the regulation of UV radiation, ozone concentration, and global warming. Algae can be valuable in understanding and resolving certain environmental issues.
Deciphering short stature in children
Nella Polidori,Valeria Castorani,Angelika Mohn,Francesco Chiarelli 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.2
Short stature is a common reason for referral to pediatric endocrinologists. Multiple factors, including genetic, prenatal, postnatal, and local environmental factors, can impair growth. The majority of children with short stature, which can be defined as a height less than 2 standard deviation score below the mean, are healthy. However, in some cases, they may have an underlying relevant disease; thus, the aim of clinical evaluation is to identify the subset of children with pathologic conditions, for example growth hormone deficiency or other hormonal abnormalities, Turner syndrome, inflammatory bowel disease, or celiac disease. Prompt identification and management of these children can prevent excessive short stature in adulthood. In addition, a thorough clinical assessment may allow evaluation of the severity of short stature and likely growth trajectory to identify the most effective interventions. Consequently, appropriate diagnosis of short stature should be performed as early as possible and personalized treatment should be started in a timely manner. An increase in knowledge and widespread availability of genetic and epigenetic testing in clinical practice in recent years has empowered the diagnostic process and appropriate treatment for short stature. Furthermore, novel treatment approaches that can be used both as diagnostic tools and as therapeutic agents have been developed. This article reviews the diagnostic approach to children with short stature, discusses the main causes of short stature in children, and reports current therapeutic approaches and possible future treatments.
Usefulness of nBos d 4, 5 and nBos d 8 Specific IgE Antibodies in Cow’s Milk Allergic Children
Anna Cingolani,Sabrina Di Pillo,Marzia Cerasa,Daniele Rapino,Nicola Pietro Consilvio,Marina Attanasi,Alessandra Scaparrotta,M. Loredana Marcovecchio,Angelika Mohn,Francesco Chiarelli 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.2
Purpose: The aim of study was to assess the value of recombinants in predicting the degree of symptoms in children with and without anaphylaxisto cow’s milk. Methods: The study included 79 children (70±40 months) referred to the Allergological Unit of the Pediatric Department betweenthe years 2008-2012. Group A was composed of 17 children (78±49.6 months) with anaphylaxis after ingestion of milk. Group B was composed of62 children (73.1±38.6 months) without a history of anaphylaxis, but with less severe symptoms (gastrointestinal and/or skin symptoms). All patientsfrom Group B had a positive open challenge with cow’s milk. All patients underwent an allergic evaluation and blood samples were collectedto test for IgE to recombinans of milk (nBos d 4, 5, 8). Results: A significant difference in nBos d 8 emerged with higher levels in Group A (median[IQR]=2.80 [0.91-16.1]) than B (0.65 [0.24-1.67]; P=0.006), whereas there were no statistically significant differences for nBos d 4 and 5. The recombinants’sum was higher in Group A than B: 8.39 [2.72-41.39] vs 3.04 [1.85-7.31] kUA/L; P=0.044. The recombinant nBos d 8 was superior to the otherrecombinants in identifying children at risk for anaphylaxis, with an area under the curve of 0.718 (95% CI, 0.57-0.86, P=0.006). Considering acutoff of 1.8 kUA/L, nBos d 8 had the most favorable sensitivity and specificity ratio (sensitivity=0.65, specificity=0.77) with an odd ratio of 6.02(95% C.I: 1.89-19.23). Conclusions: This study suggested 2 phenotypes of allergic children, “high-anaphylaxis-risk” and “milder-risk”. These typescan be differentiated through measuring the level of IgE to nBos d 8. Key Words: Child; symptoms; milk; allergy; recombinant proteins