http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yamada, Ikuhiro,Matsuyama, Masato,Ozaka, Masato,Inoue, Dai,Muramatsu, Yusuke,Ishii, Hiroshi,Junko, Ueda,Ueno, Makoto,Egawa, Naoto,Nakao, Haruhisa,Mori, Mitsuru,Matsuo, Keitaro,Nishiyama, Takeshi,Ohkaw Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Background: We aimed to evaluate the role of genetic polymorphisms in tobacco carcinogen-metabolizing genes and their interactions with smoking in a hospital-based case-control study of Japanese subjects. Materials and Methods: We examine the associations of pancreatic cancer risk with genetic polymorphisms in GSTM1, GSTT1 and GSTP1, phase II enzymes that catalyze the conjugation of toxic and carcinogenic electrophilic molecules. The study population consisted of 360 patients and 400 control subjects, who were recruited from several medical facilities in Japan. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and pancreatic cancer risk. Results: Among the control subjects, the prevalence of the GSTM1-null genotype and the GSTT1-null genotype was approximately 56% and 48%, respectively. Cases and controls were comparable in terms of GSTM1 and GSTT1 genotype distributions. Neither of the deleted polymorphisms in GSTM1 and GSTT1 was associated with the risk of pancreatic cancer, with an age- and sex-adjusted OR of 0.99 (95%CI: 0.74-1.32) for the GSTM1-null genotype, and 0.98 (95%CI: 0.73-1.31) for the GSTT1-null genotype. The OR was 0.97 (95%CI: 0.64-1.47) for individuals with the GSTM1 and GSTT1-null genotypes compared with those with the GSTM1 and GSTT1- present genotypes. No synergistic effects of smoking or GST genotypes were observed. Conclusions: Our results indicate no overall association between the GSTM1 and GSTT1 deletion polymorphisms and pancreatic cancer risk in the Japanese subjects in our study.
Koji Kinoshita,Yuki Banno,Yuki Ono,Shohey Yamada,Mitsuru Handa 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.3
This study experimentally investigates eff ect of fatigue strength improvement of the Portable Pneumatic Needle-Peening treatment (PPP treatment) as a needle peening on out-of-plane gusset welded joints by using plate bending fatigue tests. This study also examined eff ect of the travel speed and the number of treatment passes of the PPP treatment with regards to its fatigue strength improvement. After the fatigue tests, the observation of the fracture surface with Scanning Electron Microscope was carried out in order to clarify the crack initiation. From those test results, it may be concluded that the eff ect of fatigue strength improvement might be governed by treatment passes with suffi cient travel speed. In addition, this study carried out additional fatigue tests that focus on fatigue crack closer by using the PPP treatment. As a result of additional fatigue tests for fatigue crack closure, it might be said that the eff ect of fatigue crack closure is eff ective when the distance between fatigue cracks and treatment area is less than 2.0 mm.
Fatigue Strength Improvement of Welded Joints of Existing Steel Bridges by Shot-Peening
Koji Kinoshita,Yuki Banno,Yuki Ono,Shohey Yamada,Mitsuru Handa 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.2
Shot-peening recently can be applied to existing steel bridges due to the development of new vacuuming techniques of shots after peening in the construction site. This study experimentally investigates eff ects of fatigue strength improvement of shot-peening on welded joints. Bending fatigue tests using out-of-plane gusset welded joints specimens were carried out and three type specimens were compared: as-welded, grit-blasted, and shot-peened. In addition, this paper examines diff erences of fatigue strength improvement eff ects in case of applying shot-peening to inside of scallop where shots might be diffi cult to hit perpendicularly to weld toe of welded joints because of narrow space, and the residual stress measurement in order to clarify introducing compressive residual stress were carried out. As a result, it may be concluded that shot-peening can improve fatigue strength of welded joints and its mechanism was identifi ed as extension of crack initiation life and delay crack propagation due to benefi cial compressive residual stress in the vicinity of surface layer.
Mutsuo Yamaya,Kazuhiro Nomura,Kazuya Arakawa,Mitsuru Sugawara,Xue Deng,Nadine Lusamba Kalonji,Hidekazu Nishimura,Mitsuhiro Yamada,Ryoichi Nagatomi,Tetsuaki Kawase 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.5
Rhinoviral infection is associated with anincreased risk of asthma attacks. The macrolide clarithromycindecreases cytokine production in nasopharyngealaspirates from patients with wheezing, but the effectsof macrolides on cytokine production in nasal epithelialcells obtained from asthmatic subjects remain unclear. Here, human nasal epithelial cells were infected with type-14 rhinovirus (RV14), a major RV group. Titers and RNAof RV14 and cytokine concentrations, including IL-1b andIL-6, were higher in the supernatants of the cells obtainedfrom subjects with bronchial asthma (asthmatic group) thanin those from the non-asthmatic group. Pretreatment withclarithromycin decreased RV14 titers, viral RNA andcytokine concentrations, and susceptibility to RV14infection. Pretreatment with clarithromycin also decreasedIL-33 production, which was detected after infection. Pretreatment with clarithromycin decreased the expressionof intercellular adhesion molecule-1, the receptor forRV14, after infection, the number and fluorescence intensityof the acidic endosomes through which RV RNAenters the cytoplasm, and the activation of nuclear factorkappa-B proteins in nuclear extracts. These findings suggestedthat RV replication and cytokine production may beenhanced in nasal epithelial cells obtained from subjectswith bronchial asthma and may be modulated byclarithromycin.