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RISS 인기검색어
- 검색키워드
- 저자 : Mingming Lv (검색결과 5 건)
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Mingming Wang,Jianyun Chen,Shuli Fan,Shaolan Lv 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.4
In order to study the dynamic failure mechanism and aseismic measure for high concrete gravity dam under earthquake, the comparative models experiment on the shaking table was conducted to investigate the dynamic damage response of concrete gravity dam with and without the presence of reinforcement and evaluate the effectiveness of the strengthening measure. A new model concrete was proposed and applied for maintaining similitude with the prototype. A kind of extra fine wires as a substitute for rebar was embedded in four-points bending specimens of the model concrete to make of reinforced model concrete. The simulation of reinforcement concrete of the weak zones of high dam by the reinforced model concrete meets the similitude requirements. A tank filled with water is mounted at the upstream of the dam models to simulate the reservoir. The Peak Ground Acceleration (PGA) that induces the first tensile crack at the head of dam is applied as the basic index for estimating the overload capacity of high concrete dams. For the two model dams with and without strengthening tested, vulnerable parts of them are the necks near the crests. The results also indicate that the reinforcement is beneficial for improving the seismicresistant capacity of the gravity dam.
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Wang, Mingming,Chen, Jianyun,Fan, Shuli,Lv, Shaolan Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.4
In order to study the dynamic failure mechanism and aseismic measure for high concrete gravity dam under earthquake, the comparative models experiment on the shaking table was conducted to investigate the dynamic damage response of concrete gravity dam with and without the presence of reinforcement and evaluate the effectiveness of the strengthening measure. A new model concrete was proposed and applied for maintaining similitude with the prototype. A kind of extra fine wires as a substitute for rebar was embedded in four-points bending specimens of the model concrete to make of reinforced model concrete. The simulation of reinforcement concrete of the weak zones of high dam by the reinforced model concrete meets the similitude requirements. A tank filled with water is mounted at the upstream of the dam models to simulate the reservoir. The Peak Ground Acceleration (PGA) that induces the first tensile crack at the head of dam is applied as the basic index for estimating the overload capacity of high concrete dams. For the two model dams with and without strengthening tested, vulnerable parts of them are the necks near the crests. The results also indicate that the reinforcement is beneficial for improving the seismic-resistant capacity of the gravity dam.
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LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p
Qu Huan,Li Xingxing,Chen Fei,Zhang Min,Lu Xun,Gu Yun,Lv Mingming,Lu Cheng 한국유전학회 2023 Genes & Genomics Vol.45 No.5
Background Long-non-coding RNA PVT1 (lncRNA PVT1) can be used as an oncogenic regulatory non-coding RNA (ncRNA) for many cancers. However, its function and mechanism in breast cancer (BRCA) are still not clearly elucidated. Objective We attempt to explain the mechanism of PVT1’s role in breast cancer from different perspectives. Methods We analyzed the expression of PVT1 and its correlation with the breast cancer related clinical data in the The Cancer Genome Atlas (TCGA) database. We used PVT1 overexpression and knockdown lentivirus to infect breast cancer MDA-MB-231 cell line for cell function verification, in vitro using CCK-8 to measure proliferation, flow cytometry to measure apoptosis, transwell test to measure invasion and migration ability, detecting cell extracellular acidification rate (ECAR) to assess glycolysis metabolism and explore the biological functions of PVT1 in breast cancer cells. Transcriptome sequencing was used to analyze the changes of related genes in cells after overexpression of PVT1. In vivo we used a xenograft model to study the effect of PVT1 on breast cancer. Results PVT1 was up-regulated in breast cancer tissues and was positively correlated with the clinical stage of breast cancer patients. Overexpression of PVT1 in vitro promoted cell proliferation, migration and invasion, and promoted tumor growth in vivo. Knockdown of PVT1 led to the opposite biological consequence. Further bioinformatics analysis showed that PVT1 changes the glycolysis metabolism of tumors through regulation of glycolysis-related genes. In addition, the expression of miR-145-5p is negatively correlated with PVT1. We consider the possibility of PVT1 promoting cell proliferation and metastasis by regulating the aerobic glucose metabolism in breast cancer cells through sponging the miR-145-5p. Conclusion Our results reveal a potential pathway for competing endogenous RNA to regulate breast cancer glucose metabolism. PVT1 regulates glycolysis related genes expression by competitively binding to endogenous miR-145-5p in breast cancer cells to change the metabolic phenotype. This may Provide new ideas for precise molecular therapy targets for breast cancer.
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Capture of CO2 from coal using chemical-looping combustion: Process simulation
Ming Luo,Shuzhong Wang,Jiabin Zhu,Longfei Wang,Mingming Lv 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.3
Coal direct chemical-looping combustion (CLC) and coal gasification CLC processes are the two basicapproaches for the application of the CLC technology with coal. Two different combined cycles with the overall thermalinput of 1,000MW (LHV) were proposed and simulated, respectively, with NiO/NiAl2O4 as an oxygen carrierusing the ASPEN software. The oxygen carrier circulation ratio in two CLC processes was calculated, and the influenceof the CLC process parameters on the system performance such as air reactor temperature and the turbine inletsupplementary firing temperature was investigated. Results found were that the circulation ratio of the oxygen carrierin the coal gasification CLC process is smaller than that in the coal direct CLC process. In the coal direct CLCcombined system, the system efficiency is 49.59% with the CO2 capture efficiency of almost 100%, assuming the airreactor temperature at 1,200 oC and the fuel reactor temperature at 900 oC. As a comparison, the system efficiency ofcoal gasification CLC combined system is 40.53% with the CO2 capture efficiency of 85.2% when the turbine inlet temperatureis at 1,350 oC. Increasing the supplementary firing rate or decreasing the air reactor temperature can increasethe system efficiency, but these will reduce the CO2 capture efficiency.
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