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Kim, Don-Kyu,Jeong, Jae-Ho,Lee, Ji-Min,Kim, Kwang Soo,Park, Seung-Hwan,Kim, Yong Deuk,Koh, Minseob,Shin, Minsang,Jung, Yoon Seok,Kim, Hyung-Seok,Lee, Tae-Hoon,Oh, Byung-Chul,Kim, Jae Il,Park, Hwan Tae Nature Publishing Group, a division of Macmillan P 2014 Nature medicine Vol.20 No.4
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters host iron metabolism for its own survival, we examined the role of nuclear receptor family members belonging to the NR3B subfamily in mouse hepatocytes. Here, we report that estrogen-related receptor γ (ERRγ, encoded by Esrrg) modulates the intramacrophage proliferation of S. typhimurium by altering host iron homeostasis, and we demonstrate an antimicrobial effect of an ERRγ inverse agonist. Hepatic ERRγ expression was induced by S. typhimurium–stimulated interleukin-6 signaling, resulting in an induction of hepcidin and eventual hypoferremia in mice. Conversely, ablation of ERRγ mRNA expression in liver attenuated the S. typhimurium–mediated induction of hepcidin and normalized the hypoferremia caused by S. typhimurium infection. An inverse agonist of ERRγ ameliorated S. typhimurium–mediated hypoferremia through reduction of ERRγ–mediated hepcidin mRNA expression and exerted a potent antimicrobial effect on the S. typhimurium infection, thereby improving host survival. Taken together, these findings suggest an alternative approach to control multidrug-resistant intracellular bacteria by modulating host iron homeostasis.
Kim, Don-Kyu,Gang, Gil-Tae,Ryu, Dongryeol,Koh, Minseob,Kim, Yo-Na,Kim, Su Sung,Park, Jinyoung,Kim, Yong-Hoon,Sim, Taebo,Lee, In-Kyu,Choi, Cheol Soo,Park, Seung Bum,Lee, Chul-Ho,Koo, Seung-Hoi,Choi, Hu American Diabetes Association 2013 Diabetes Vol.62 No.9
<P>Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder with diverse pathological manifestations and is often associated with abnormal regulation of hepatic glucose production. Many nuclear receptors known to control the hepatic gluconeogenic program are potential targets for the treatment of T2DM and its complications. Nevertheless, the therapeutic potential of the estrogen-related receptor γ (ERRγ) in T2DM remains unknown. In this study, we show that the nuclear receptor ERRγ is a major contributor to hyperglycemia under diabetic conditions by controlling hepatic glucose production. Hepatic ERRγ expression induced by fasting and diabetic conditions resulted in elevated levels of gluconeogenic gene expression and blood glucose in wild-type mice. Conversely, ablation of hepatic ERRγ gene expression reduced the expression of gluconeogenic genes and normalized blood glucose levels in mouse models of T2DM: <I>db</I>/<I>db</I> and diet-induced obesity (DIO) mice. In addition, a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in <I>db</I>/<I>db</I> and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production. Our findings suggest that the ability of GSK5182 to control hepatic glucose production can be used as a novel therapeutic approach for the treatment of T2DM.</P>
Minseob Shim,Jungmoon Kim,Junwon Jeong,Sejin Park,Chulwoo Kim IEEE 2015 IEEE journal of solid-state circuits Vol.50 No.10
<P>A piezoelectric (PE) energy harvesting system with one-cycle maximum power point (MPP) sensing is presented. The one-cycle MPP sensing method uses a very small size sensing capacitor and it can make the transducer output voltage reach the open circuit voltage within one cycle. The proposed MPP sensing block can sense the open circuit voltage with a proposed peak detector and stores the MPP voltage using charge sharing blocks. The one-cycle MPP sensing approach simplifies the design of an MPP tracking algorithm and greatly reduces the tracking time. All control blocks are self-biased and choose the higher voltage between the input or output voltages of the switching converter as a supply voltage (V DD). Therefore, a voltage multiplexer and a low-power ramp generator with V DD independence are also proposed to control the system without additional DC to DC converter. The entire system has been implemented in a 0.35 μm BCDMOS process. It operates at 90 kHz with a 10-mH inductor. The total power dissipation of the controller is 10 μW at a V DD of 2.7 V. The MPP tracking time is only 9.09 ms/V when the input voltage of the switching converter is changed from 3.4 V to 1.2 V.</P>
Kim, Don-Kyu,Kim, Yong-Hoon,Jang, Hyun-Hee,Park, Jinyoung,Kim, Jung Ran,Koh, Minseob,Jeong, Won-Il,Koo, Seung-Hoi,Park, Tae-Sik,Yun, Chul-Ho,Park, Seung Bum,Chiang, John Y L,Lee, Chul-Ho,Choi, Hueng-S BMJ Publishing Group Ltd 2013 Gut: journal of the British Society of Gastroenter Vol.62 No.7
<P>Background The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease. The nuclear hormone receptor oestrogen-related receptor gamma (ERR gamma) is a constitutively active transcriptional activator regulating gene expression. Objective To investigate the role of ERR gamma in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERR gamma inverse agonist. Design For chronic alcoholic hepatosteatosis study, C57BL/6J wild-type and CB1(-/-) mice were administered alcohol for 4 weeks. GSK5182 and chlormethiazole (CMZ) were given by oral gavage for the last 2 weeks of alcohol feeding. Gene expression profiles and biochemical assays were performed using the liver or blood of mice. Results Hepatic ERR gamma gene expression induced by alcohol-mediated activation of CB1 receptor results in induction of CYP2E1, while liver-specific ablation of ERR. gene expression blocks alcohol-induced expression of CYP2E1 in mouse liver. An ERR gamma inverse agonist significantly ameliorates chronic alcohol-induced liver injury in mice through inhibition of CYP2E1-mediated generation of ROS, while inhibition of CYP2E1 by CMZ abrogates the beneficial effects of the inverse agonist. Finally, chronic alcohol-mediated ERR gamma and CYP2E1 gene expression, ROS generation and liver injury in normal mice were nearly abolished in CB1(-/-) mice. Conclusions ERR gamma, as a previously unrecognised transcriptional regulator of hepatic CB1 receptor, controls alcohol-induced oxidative stress and liver injury through CYP2E1 induction, and its inverse agonist could ameliorate oxidative liver injury due to chronic alcohol exposure.</P>
( Minseob Kim ),( Suk Kyun Hong ),( Kyung-suk Suh ),( Hye Young Woo ),( Kyung Chul Yoon ),( Jeong-moo Lee ),( Jae-hyung Cho ),( Nam- Joon Yi ),( Kwang-woong Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Biliary complications after liver transplantation(LT) are most common complications and associated with morbidity and mortality. Currently, the generally applied first intervention for post-LT biliary complications is Endoscopic retrograde cholangiopancreatography(ERCP) because of less invasiveness and patient convenience. However, there has not been a uniform conclusion published on superiority of the two types of intervention as first trial. Therefore, we compared the efficacy of ERCP and percutaneous transhepatic biliary drainage(PTBD) as a first line treatment of post-LT biliary problems. Methods: From January 2013 to December 2016, 565 patients underwent LT in Seoul National University Hospital(SNUH). Medical records of LT recipients with biliary complications retrospectively reviewed. Long-term follow-up was evaluated using cholangiogram, computed tomography(CT) scan and laboratory parameters. Results: Among 565 LT patients, 85 patients(15.0%) were treated by intervention including ERCP and PTBD with diagnosis of biliary complications. Successful intervention on the first attempt was achieved in 36 of 60 patients(60.0%) with ERCP, and 19 of 25 patients(76.0%) with PTBD, respectively(P=0.16). We also classified the groups based on the location of the biliary complications and compared the success rate; one with anterior bile duct problems (a-BD, n=29) and another with posterior bile duct (p-BD, n=14). In a-BD, there was no difference in the intervention success rate of PTBD and ERCP(25% vs.24%, P=0.692). However, in p-BD, PTBD success rate was significantly better than ERCP(75% vs.18%, P=0.002). Conclusions: PTBD could be considered as more effective procedure for termination of treatment in patients with post-LT biliary complications, especially posterior duct problems.
No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
Eom, Minseob,Abdul-Ghafar, Jamshid,Park, Sun-Mi,Han, Joung Ho,Hong, Soon Won,Kwon, Kun Young,Ko, Eun Suk,Kim, Lucia,Kim, Wan Seop,Ha, Seung Yeon,Lee, Kyo Young,Lee, Chang Hun,Yoon, Hye Kyoung,Choi, Yo The Korean Society of Pathologists and The Korean 2013 KOREAN JOURNAL OF PATHOLOGY - Vol.47 No.2
<P><B>Background</B></P><P>Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA.</P><P><B>Methods</B></P><P>We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA.</P><P><B>Results</B></P><P>Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls.</P><P><B>Conclusions</B></P><P>SV40 is not associated with the development of MM in Korea.</P>
통합교과 구성 차시 수업에 대한 초등학교 교사의 관심도와 실행수준 분석
김민섭 ( Minseob Kim ),박일수 ( Ilsoo Park ) 한국통합교육과정학회 2022 통합교육과정연구 Vol.16 No.4
The purpose of this study is to analyze the teachers’ Stages of Concern and Levels of Use in the integrated curriculum blank lessons. To this end, 146 elementary school teachers who have experience in teaching integrated subjects blank lessons in G-do were analyzed for the Stages of Concern and Levels of Use in the blank lessons, and a Chi-square test was conducted to determined the relationship between them. The following research results were obtained. First, elementary school teacher’s concern in the blank lessons was the highest in the Unconcerned stage, and the lowest in the Consequence stage. Second, elementary school teacher’s levels of use in the blank lessons was the highest in the Mechanical Use, and the Nonuse was the second highest. Third, there is a relationship between the Stages of Concern and Levels of Use of elementary school teachers in the blank lessons. This study has the following implications. First, it is necessary to take into account the teacher factors in the process of blank lessons. Second, it is necessary to establish a training and support system that can improve by identifying the Stages of Concern and Levels of Use.