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KIM, MIHYUNG,KIM, INOK,LEE, SUNG KOO,BANG, SA IK,LIM, SO YOUNG Blackwell Publishing Inc 2011 Dermatologic surgery Vol.37 No.6
<P><B>BACKGROUND </B> Adipose tissue–derived stem cells (ASCs) are considered to be a reliable cell source for the generation of adipose tissue because they can be differentiated into adipocytes. Previous data have indicated that adipogenic differentiation of ASCs before transplantation can enhance the regeneration of adipose tissue.</P><P><B>OBJECTIVE </B> To evaluate the efficacy and safety of the use of autologous differentiated adipocytes for the treatment of depressed scars.</P><P><B>METHODS </B> Autologous differentiated adipocytes were produced using well‐established techniques, including the harvesting of stromal vascular fraction cells from lipoaspirates, expansion of ASCs, and differentiation into adipocytes. This was an open‐label, dose‐escalation study. Patients were given a subcutaneous injection of differentiated adipocytes and followed for 12 weeks.</P><P><B>RESULTS </B> Thirty‐one patients were injected with differentiated adipocytes. When the differentiated adipocytes were injected subcutaneously into depressed scars, the average recovery in volume was 74.6% at 12 weeks. Of 17 patients who completed the follow‐up after determination of dose, seven were willing to enroll for extended follow‐up. Long‐term follow‐up revealed that the recovery in volume at 12 weeks was maintained well for at least 1 year. There were no significant adverse events.</P><P><B>CONCLUSIONS </B> The use of autologous differentiated adipocytes can be a safe and effective treatment for soft tissue defects, with relatively long‐term maintenance of volume.</P><P> <I>The authors have indicated no significant interest with commercial supporters</I>.</P>
Kim, SoJung,Kim, MiHyung,Kim, KilHyoun The Korean Association of Immunobiologists 2004 Immune Network Vol.4 No.3
Background: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of the germline lineage. Differently from normal somatic cells with no telomerase activity, normal lymphocytes has been reported to have telomerase activity comparable to that found in transformed cells during development and activation, which substantiate a role in supporting the capacity of lymphocytes for extensive clonal expansion. Methods: Here, in order to define the telomerase regulation in murine T lymphocytes, telomerase activity in cloned murine $CD8^+$ T cells and naive $CD8^+$ T cells isolated from C57BL/6 mice was examined. Next, the regulatory mechanism of telomerase activity at transcriptional and post- translational levels was investigated by determining the expression level of the TERT protein, a key component for telomerase activity. Results: It was demonstrated that telomerase activity was expressed in an inactivated state as well as in an activated state in the murine $CD8^+$ T lymphocytes by using TRAP assay. The increase of telomerase activity was partially dependent on the net increase of TERT expression. Also, telomerase activity was decreased after treatment with protein kinase inhibitors, indicating that telomerase activation was prevented by inhibition of phosphorylation. Conclusion: Therefore, these results suggest that telomerase activity is constitutively expressed in the murine resting T lymphocytes and controlled by both transcriptional regulation and post- ranslational modifications.
Diversity and Complexity of CD8^+ T Cell Responses against a Single Epitope of Adenovirus E1B
Kim, Mihyung,Kim, Kilhyoun 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
This study describes the characteristics of the immune responses against adenovirus in 057BL/6 mice. CTL responsescould be induced against E1Bp of adenovirus type 5, when whole viruses were immunized. A panel of ElBp-specific CTLclones showed a wide range of T cell avidity, Recognition of the E1BP Peptide and a panel of variant peptides containing asingle alanine substitution by CTL clones revealed that the fine specificity of the CTL response was quite diverse, rather thanbeing limited to a certain clonal preference. Moreover, the variant peptides with a substitution at the TCR contact residue hadantagonistic properties to some of the CTL clones, while being agonistic to others, reflecting the exxtensive diversity of the T cellsThese results imply fat the functional diversity of T cells to even a single epitope should be considered in manipulating immunityto viruses and in developing adoptive immunotherapy for imnunocompromised individuals.
이원종,Chang-Hwan Moon,Wonkyoung Yoon,Mihyung Kim,Woo-Jin Kim,Kyung-Min Kim,Haebeom Lee,Seong-Mok Jeong,Jae Hyeon Yu,Dae-Hyun Kim 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.3
Del-Nido cardioplegia (DNc) is a single-dose cardioplegia that is widely used in human medicine because of its long duration. In this report, we describe two cases of open-heart surgery with cardiopulmonary bypass (CPB) using DNc. One dog was diagnosed with partial atrioventricular septal defect, and the other dog was diagnosed with myxomatous mitral valve disease stage D. Both dogs were treated with open-heart surgery with DNc to induce temporary cardiac arrest. No complications from DNc were observed, and the patients were discharged. Veterinary heart surgeons should consider DNc as an option for temporary cardiac arrest during open-heart surgery with CPB.
김미형,김건하,Kim, Mihyung,Kim, Geonha 한국지하수토양환경학회 2013 지하수토양환경 Vol.18 No.1
A lot of burial sites for the disposal of the contagious livestock slaughtered by foot and mouth disease were constructed in a short time for preventing the rapid spread of the virus. More than 4,700 carcass burial sites were constructed in 2011. Approximately 7 million poultry and 3.5 million livestock including head of cattle and swine were buried in farm land. However, the available cost data for a burial site was not provided. This study was to performed in order to understand the economic issues related to carcass burial disposal. The data from a local government was analyzed and the assumption data web based was constructed to evaluate the cost for constructing a carcass burial. The results showed that the local government paid KRW 5,386 for the burial disposal of a mortality (swine). It was estimated that the cost could be reduced through an appropriate measures.
LEE, JUNG EUN,KIM, INOK,KIM, MIHYUNG Blackwell Publishing Inc 2010 Dermatologic surgery Vol.36 No.7
<P>BACKGROUND</P><P>Although frozen adipose tissue is frequently used for soft tissue augmentation, the viability of frozen fat remains a controversy. The cryopreservation of adipose tissue is important for the future use of adipose-derived stem cells (ASCs) and adipocytes.</P><P>OBJECTIVE</P><P>To determine whether optimal cryopreservation techniques with regard to the addition of cryopreservative agents and preservation temperature is essential for the long-term storage of adipose tissue and whether ASCs from cryopreserved adipose aspirates are reliable for use in adipogenic differentiation.</P><P>MATERIALS AND METHODS</P><P>Adipose tissue was frozen directly or with cryoprotectant at −20°C or −80°C for 1 year. The viability of adipose aspirates and the differentiation of ASCs isolated from adipose tissue were evaluated.</P><P>RESULTS</P><P>The viability of adipose aspirates frozen with dimethyl sulfoxide at −80°C was approximately 87% after 2 months of storage. Moreover, ASCs from adipose tissue stored with cryoprotectant survived successfully for 1 year and differentiated into adipocytes, although ASCs were not detected in the directly frozen adipose tissue.</P><P>CONCLUSION</P><P>Adipose tissue cryopreserved with cryoprotectant and stored at optimal temperature might prove to be a reliable source of human ASCs and adipocytes.</P><P><I>The authors have indicated no significant interest with commercial supporters.</I></P>