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Jang, Yoon-Jung,Lee, Hyun-Mee,Jang, Kyeung-Joo,Lee, Jae-Cheol,Kim, Seog-K.,Cho, Tae-Sub Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.5
The $[Ru(tpy)_2]Cl_2$ (tpy:2,2':6',2"-terpyridine) complex was synthesized and its structure was confirmed by $^1H$-NMR and elemental analysis. Its binding mode toward DNA was compared with the well-known $[Ru(bpy)_3]Cl_2$ (bpy:2,2-bipyridyl), using isotropic absorption, linear dichroism(LD) spectroscopy, and an energy minimization study. Compared to $[Ru(bpy)_3]^{2+}$, the $[Ru(tpy)_2]^{2+}$ complex exhibited very little change in its absorption pattern, especially in the MLCT band, upon binding to DNA. Furthermore, upon DNA binding, both Ru(II) complexes induced a decrease in the LD magnitude in the DNA absorption region. The $[Ru(tpy)_2]^{2+}$ complex produced a strong positive LD signal in the ligand absorption region, which is in contrast with the $[Ru(bpy)_3]^{2+}$ complex. Observed spectral properties led to the conclusion that the interaction between the ligands and DNA bases is negligible for the $[Ru(tpy)_2]^{2+}$ complex, although it formed an adduct with DNA. This conclusion implies that both complexes bind to the surface of DNA, most likely to negatively charged phosphate groups via a simple electrostatic interaction, thereby orienting to exhibit the LD signal. The energy minimization calculation also supported this conclusion.
( Ji Hoon Jang ),( Guang Won Seo ),( Sang Hoon Seol ),( Pil Sang Song ),( Dong Kie Kim ),( K Hun Kim ),( Woo Gyeong Kim ),( Yeon Mee Kim ),( Hee Jae Jun ),( Doo Il Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Soft tissue sarcoma is the most common malignant cardiac tumor. The chief modes of presentation are embolization, obstruction, and arrhythmogenesis. A case of a synovial sarcoma involving the heart of a 27 year old man is described. The patient presented with nausea and dyspnea on exertion. Transthoracic echocardiography and computed tomography revealed a huge mass in the right heart that extended through the inferior vena cava and the right renal vein to the right kidney. Aggressive surgical management was done with radical nephrectomy, IVC mass excision, and intra-arterial tumor resection. Immunohistochemical analysis of resected cardiac mass revealed it to be a monophasic synovial sarcoma, composed of fairly low uniform grade spindle cells, and Transducin-like enhancer of split TLE1 was positive with the characteristic t (X; 18) (p11. 2; q11. 2) translocation. After surgery, the patient received serial adjuvant chemotherapy with adriamycine and ifosfamide. To date, he is alive with no signifi cant clinical issues after primary surgery. We herein represent the case with a brief review.
Binding Modes of New Bis-Ru(II) Complexes to DNA: Effect of the Length of the Linker
Kwon, Byung-Hyang,Choi, Byung-Hoon,Lee, Hyun-Mee,Jang, Yoon-Jung,Lee, Jae-Cheol,Kim, Seog-K. Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.6
Bis-[dipyrido[3,2-$\alpha$:2',3'-c]phenazine)$_2$(1,10-phenanthroline)$_2Ru_2$]$^{2+}$ complexes (bis-Ru(II) complexes) tethered by linkers of various lengths were synthesized and their binding properties to DNA investigated by normal absorption and linear dichroism spectra, and fluorescence techniques in this study. Upon binding to DNA, the bis-Ru(II) complex with the longest linker (1,3-bis-(4-pyridyl)-propane), exhibited a negative $LD^r$ signal whose intensity was as large as that in the DNA absorption region, followed by a complicate $LD^r$ signal in the metal-to-ligand charge transfer region. The luminescence intensity of this bis-Ru(II) complex was enhanced. The observed $LD^r$ and luminescence results resembled that of the [Ru(1,10-phenanthroline)$_2$ dipyrido[3,2-$\alpha$:2',3'-c]phenazine]$^{2+}$ complex, whose dipyrido[3,2-$\alpha$:2',3'-c]phenazine (dppz) ligand has been known to intercalate between DNA bases. Hence, it is conclusive that both dppz ligands of the bis-Ru(II) complex intercalate. The binding stoichiometry, however, was a single intercalated dppz per ~ 2.3 bases, which violates the "nearest binding site exclusion" model for intercalation. The length between the two Ru(II) complexes may be barely long enough to accommodate one DNA base between the two dppz ligands, but not for two DNA bases. When the linker was shorter (4,4'-bipyridine or 1,2-bis-(4-pyridyl)-ethane), the magnitude of the LD in the dppz absorption region, as well as the luminescence intensity of both bis-Ru(II) complexes, was half that of the bis-Ru(II) complex bearing a long linker. This observation can be elucidated by a model whereby one of the dppz ligands intercalates while the other is exposed to the aqueous environment.
감시림프절 전이 양성인 유방암 환자에서 비감시림프절 전이 예측인자 및 예측체계의 비교 분석
박재영(Jae Young Park),박근명(Keun Myoung Park),박정미(Jeong Mi Park),이강연(Kang Yeun Lee),문연희(Youn Hee Moon),김세중(Sei Joong Kim),김준미(Joon Mee Kim),조영업(Young Up Cho),김장용(Jang Yong Kim),최윤미(Yun-Mee Choe),최선근(Sun K 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.1
Purpose: The purpose of this study was to investigate the predictors of nonsentinel lymph node (NSLN) metastasis in breast cancer and to evaluate the usefulness of the scoring systems and nomograms. Methods: In this analysis, we reviewed the clinicopathologic features of 70 patients who had undergone sentinel lymph node (SLN) biopsy and axillary lymph node dissection. The clinical features of patients, histologic parameters and hormonal receptor status of primary tumor and histopathologic features of SLN metastasis were noted retrospectively. Furthermore, the receiver operating characteristic (ROC) curve was drawn and the area under the ROC curve (AUC) was calculated to assess the discriminative power of the scoring systems and nomograms. Results: The metastatic tumor size in SLN (P<0.001), extracapsular invasion (P=0.002), percentage of positive SLNs among the removed SLNs (P=0.011), primary tumor size (P=0.038) were associated significantly with NSLN metastasis, statistically, in univariate analysis. Based on multivariate logistic regression, the metastatic tumor size was the only prognostic factor of NSLN metastasis (P=0.012). The AUC of Memorial Sloan-Kettering Cancer Center scoring system was greater than other systems, significantly (P=0.004). Conclusion: We have shown in this study that it would be possible to predict NSLN status based on the metastatic tumor size in SLN. Although the significance was not achieved in multivariate analysis, the size of primary tumor, extracapsular invasion of metastasis in SLN, percentage of positive SLNs among the removed SLNs had the potential to be a predictive factor of NSLN metastasis. MSKCC scoring system appears to be more effective and accurate than other scoring systems for selecting patients for whom axillary lymph node dissection can be avoided.