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- 저자 : Md Morshedur Rahman (검색결과 4 건)
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Md. Morshedur Rahman,Damdinsuren Boldbaatar,Min Liao,Rika Umemiya-Shirafuji,Naotoshi Tsuji,Tetsuya Tanaka,Satoshi Taharaguchi,Kozo Fujisaki 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Antimicrobial peptides represent an essential alternative first line of defense. Naturally occurring molecules associated with the innate immune system in disease-bearing vectors such as mosquito, tick could be the target for searching more potent and effective agents to combat against the pathogens resistant to conventionally used antibiotics. Recently, we explored expression of a defensinlike peptide, longicin from the hard tick Haemaphysalis longicornis. Longicin and one of its synthetic partial analog (P4) displayed antimicrobial/fungicidal/parasiticidal activity and, therefore, proposed to be a chemotherapeutic compounds against tick-borne disease organisms. Structural characterization of antimicrobial peptides is very important to understand the peptide activity. In addition, harmful side effects such as lysis of red blood cells or cytotoxicity towards mammalian host cells commonly associated with antimicrobial peptides as potential therapeutic agent should also be elucidated. In this study, we analyzed some structural features using bioinformatics tool, CD Spectroscopy, and also determined cytolytic activity of P4 peptide. According to the chemicophysical characteristics, the P4 is suggested to be a cationic peptide with hydrophobic and amphipathic character. The predicted secondary structure indicated the existence of β-sheet which was also observed in modelled tertiary structure. CD spectroscopy results also revealed the existence of a β-sheet and changes of helical content in the presence of membrane-mimic condition. These structural observations on P4 suggest that the antimicrobial activity could be due to the well developed β-sheet. In addition, sequence homology search showed that antimicrobial molecule identified in other ticks and in organisms have the P4 analogous domain at their C-terminal, which indicates P4 as a conserved antimicrobial domain. The peptide P4 also showed less cytolytic activity against various cell lines or erythrocytes of various species. The data presented here strongly suggests that the peptide P4 could be developed as future therapeutic agent against tick-borne microorganisms.
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How Do the Banks Determine Regulatory Capital, Risk, and Cost Inefficiency in Bangladesh?
RAHMAN, Mohammad Morshedur,CHOWDHURY, Md. Ali Arshad,MOUDUD-UL-HUQ, Syed Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12
This study examines simultaneous relationships between regulatory capital, risk, and cost-inefficiency for a sample of 30 commercial banks in Bangladesh from 2006 to 2018. To conduct the analysis, we used the Generalized Methods of Moments (GMM) in an unbalanced panel data framework. The empirical results show that there is a negative and significant relationship between capital regulation and credit, and overall risk. It is also evident from the results that the capital adequacy ratio is positively and significantly related to default risk and liquidity risk. Therefore, higher capitalized banks take an effort to prevent more credit risk and promote financial stability by reducing liquidity risk. Results also report that banks have been characterized as inefficient, less capitalized, and high risk. On the other hand, efficient banks are more stable but have a high level of liquidity risk. Besides, from the size of the bank, large banks are defined as having lower regulatory capital, are more risk seekers but stable with higher cost-efficiency. Notably, higher capitalized banks are more profitable and cost-efficient by reducing risk. Finally, this study also provides some insightful policy suggestions to the stakeholders.
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SANTOSH KUMAR,Md Morshedur Rahman,윤상현,김상천,오나현,홍경화,고준석 한국섬유공학회 2021 Fibers and polymers Vol.22 No.8
A zinc oxide-based polyurethane (PU) nanocomposite was synthesized using an in-situ polymerization technique,and the structure was confirmed using FT-IR and EDS elemental mapping. XRD, GPC, TGA, UV-visible spectroscopy,UTM, FE-SEM, and HR-TEM were employed to investigate the differences in the physico-chemical properties and structuralmorphology between regular and ZnO-based polyurethane (ZnO-PU). The ZnO-PU exhibited superior thermal and UVprotection properties compared to regular polyurethane. Rheological studies suggest that PU behaves as a non-Newtonianfluid and shows excellent viscoelastic properties suitable for the preparation of composite films. ZnO-PU exhibitedsignificant antimicrobial activity compared to regular polyurethane. The dyeing properties of PET/PU and PET/ZnO-PUrevealed that their partition ratios and color fastness were comparable. The overall results suggest that ZnO-PUnanocomposites can find potential applications as functional elastic materials in the textile industry.
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Rika Umemiya-Shirafuji,Tomohide Matsuo,Damdinsuren Boldbaatar,Min Liao,Banzragch Battur,Md. Morshedur Rahman,Kozo Fujisaki 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
The life cycle of ticks is characterized by alternate off-host and on-host conditions. The life span is estimated at several years and most ixodid ticks spend more than 95% of their life off the host. They seem to have a unique strategy to endure the off-host state for a long period. By electron microscopy, isolation membrane-, autophagosome- and autolysosome-like structures were found in the midgut epithelial cells of unfed ticks. Therefore, we focused on autophagy which is well-conserved from yeast to higher eukaryotes and induced by starvation. We have identified homologues of autophagy-related (ATG) genes (ATG3, ATG4 and ATG8) from cDNA libraries of the 3-host tick Haemaphysalis longicornis. Each expression profile of H. longicornis ATG (HlATG) genes and HlAtg proteins at the stages of nymph and adult were examined by real-time PCR and immunoblotting. Moreover, autophagy is known to be induced by inactivation of target of rapamycin (TOR), a phosphatidylinositol kinase. To examine the effect of TOR function on the expression of HlAtg protein(s), rapamycin, a specific inhibitor of the signal transduction mediated by TOR, was injected to unfed adults. It was revealed that the expression of HlAtg protein(s) was enhanced in response to the rapamycin. This result indicates that tick have the nutrient-sensitive TOR signaling pathway which regulate autophagy.
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