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Time Travels in a Boat: Captiva History Gallery
( Yelena Mclane ) 대한전시디자인학회 2014 전시디자인연구 Vol.11 No.1
This paper describes the interpretive and design methods utilized in the recently completed Captiva History Gallery on Captiva Island, Florida, and details the modes by which the exhibit evokes emotional reactions and stimulates cognitive responses among visitors. The case study illustrates the designers' layered presentation of informational content and visual and material elements, offers examples of interactive exhibit components, and recounts public responses to the installation.
A BLMS Adaptive Receiver for Direct-Sequence Code Division Multiple Access Systems
Hamouda Walaa,McLane Peter J. The Korea Institute of Information and Commucation 2005 Journal of communications and networks Vol.7 No.3
We propose an efficient block least-mean-square (BLMS) adaptive algorithm, in conjunction with error control coding, for direct-sequence code division multiple access (DS-CDMA) systems. The proposed adaptive receiver incorporates decision feedback detection and channel encoding in order to improve the performance of the standard LMS algorithm in convolutionally coded systems. The BLMS algorithm involves two modes of operation: (i) The training mode where an uncoded training sequence is used for initial filter tap-weights adaptation, and (ii) the decision-directed where the filter weights are adapted, using the BLMS algorithm, after decoding/encoding operation. It is shown that the proposed adaptive receiver structure is able to compensate for the signal-tonoise ratio (SNR) loss incurred due to the switching from uncoded training mode to coded decision-directed mode. Our results show that by using the proposed adaptive receiver (with decision feedback block adaptation) one can achieve a much better performance than both the coded LMS with no decision feedback employed. The convergence behavior of the proposed BLMS receiver is simulated and compared to the standard LMS with and without channel coding. We also examine the steady-state bit-error rate (BER) performance of the proposed adaptive BLMS and standard LMS, both with convolutional coding, where we show that the former is more superior than the latter especially at large SNRs ($SNR\;\geq\;9\;dB$).
Error Control Coding and Space-Time MMSE Multiuser Detection in DS-CDMA Systems
Hamouda, Walaa,McLane, Peter J. The Korea Institute of Information and Commucation 2003 Journal of communications and networks Vol.5 No.3
We consider the use of error control coding in direct sequence-code-division multiple access (OS-COMA) systems that employ multiuser detection (MUO) and space diversity. The relative performance gain between Reed-Solomon (RS) code and convolutional code (CC) is well known in [1] for the single user, additive white Gaussian noise (AWGN) channel. In this case, RS codes outperform CC's at high signal-to-noise ratios. We find that this is not the case for the multiuser interference channel mentioned above. For useful error rates, we find that soft-decision CC's to be uniformly better than RS codes when used with DS-COMA modulation in multiuser space-time channels. In our development, we use the Gaussian approximation on the interference to determine performance error bounds for systems with low number of users. Then, we check their accuracy in error rate estimation via system's simulation. These performance bounds will in turn allow us to consider a large number of users where we can estimate the gain in user-capacity due to channel coding. Lastly, the use of turbo codes is considered where it is shown that they offer a coding gain of 2.5 dB relative to soft-decision CC.
Derrick, Jeffrey S.,Kerr, Richard A.,Korshavn, Kyle J.,McLane, Michael J.,Kang, Juhye,Nam, Eunju,Ramamoorthy, Ayyalusamy,Ruotolo, Brandon T.,Lim, Mi Hee American Chemical Society 2016 Inorganic Chemistry Vol.55 No.10
<P>The complex and multifaceted pathology of Alzheimer's disease (AD) continues to present a formidable challenge to the establishment of long-term treatment strategies. Multifunctional compounds able to modulate the reactivities of various pathological features, such as amyloid-beta (A beta) aggregation, metal ion dyshomeostasis, and oxidative stress, have emerged as useful tactic. Recently, an incorporation approach to the rational design of multipurpose small molecules has been validated through the production of a multifunctional ligand (ML) as a potential chemical tool for AD. In order to further the development of more diverse and improved multifunctional reagents, essential pharmacophores must be identified. Herein, we report a series of aminoquinoline derivatives (AQ1-4, AQP1-4, and AQDA1-3) based on ML's framework, prepared to gain a structure reactivity understanding of ML's multifunctionality in addition to tuning its metal binding affinity. Our structure reactivity investigations have implicated the dimethylamino group as a key component for supplying the antiamyloidogenic characteristics of ML in both the absence and presence of metal ions. Two-dimensional NMR studies indicate that structural variations of ML could tune its interaction sites along the A beta sequence. In addition, mass spectrometric analyses suggest that the ability of our aminoquinoline derivatives to regulate metal-induced A beta aggregation may be influenced by their metal binding properties. Moreover, structural modifications to ML were also observed to noticeably change its metal binding affinities and metal-to-ligand stoichiometries that were shown to be linked to their antiamyloidogenic and antioxidant activities. Overall, our studies provide new insights into rational design strategies for multifunctional ligands directed at regulating metal ions, A beta, and oxidative stress in AD and could advance the development of improved next-generation multifunctional reagents.</P>