L-SYSTEM IN CELLULAR AUTOMATADESIGN OF ARTIFICIAL NEURAL DECISION SYSTEMS

Masanori Sugisaka,Mayumi Sato,Yong-guang Zhang,John Casti 제어로봇시스템학회 1995 제어로봇시스템학회 국내학술대회 논문집 Vol.1995 No.10

L-SYSTEM IN CELLULAR AUTOMATADESIGN OF ARTIFICIAL NEURAL DECISION SYSTEMS

Masanori Sugisaka,Mayumi Sato,Yong-guang Zhang,John Casti 제어로봇시스템학회 1995 제어로봇시스템학회 국내학술대회 논문집 Vol.1 No.1

Impact of Sleep Disorders, Quality of Life and Gastric Emptying in Distinct Subtypes of Functional Dyspepsia in Japan

( Hiroshi Yamawaki ),( Seiji Futagami ),( Mayumi Shimpuku ),( Hitomi Sato ),( Taiga Wakabayashi ),( Yuuta Maruki ),( Yasuhiro Kodaka ),( Hiroyuki Nagoya ),( Tomotaka Shindo ),( Tetsuro Kawagoe ),( Cho 대한소화기기능성질환·운동학회 2014 Journal of Neurogastroenterology and Motility (JNM Vol.20 No.1

Background/Aims The association between clinical symptoms, gastric emptying, quality of life and sleep disorders in distinct functional dyspepsia (FD) patients has not been studied yet in detail. Methods We enrolled 79 FD patients (postprandial distress syndrome [PDS], n = 65; epigastric pain syndrome [EPS], n = 47; EPS-PDS overlap, n = 33) and 44 healthy volunteers. Gastric motility was evaluated. We used Rome III criteria to evaluate clinical symptoms and State-Trait Anxiety Inventory (STAI) scores to determine anxiety status. Sleep disorder was evaluated using the Pittsburgh Sleep Quality Index scores. Results There were no significant differences in age, sex and Helicobacter pylori positivity between FD subtypes and healthy volunteers. The scores of Glasgow dyspepsia severity scores (GDSS), SF-8 and Pittsburgh Sleep Quality Index (PSQI) in distinct subtypes of FD patients were significantly different from those in healthy volunteers. However, there were not significant differences in these scores, Tmax and T1/2 among 3 subtypes of FD patients. PSQI score was significantly (P = 0.027, P = 0.002 and P = 0.039, respectively) associated with GDSS among EPS, PDS and EPS-PDS overlap patients. In addition, 8-item short form health survey (SF-8; Physical Component Score and Mental Component Score) was significantly associated with global PSQI score in PDS and EPS-PDS overlap patients. In contrast, SF-8 (Mental Component Score) only was significantly linked to global PSQI score in EPS patients. Conclusions Prevalences for sleep disorders, gastric motility and quality of life in 3 subtypes of FD patients were similar levels. In PDS and EPS-PDS overlap patients, SF-8 was significantly associated with global PSQI score. (J Neurogastroenterol Motil 2014;20:104-112)

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan

( Hiroshi Yamawaki ),( Seiji Futagami ),( Mayumi Shimpuku ),( Tomotaka Shindo ),( Yuuta Maruki ),( Hiroyuki Nagoya ),( Yasuhiro Kodaka ),( Hitomi Sato ),( Katya Gudis ),( Tetsuro Kawagoe ),( Choitsu S 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.1

Background/Aims There are no available data about the relationship between ghrelin gene genotypes and early phase of gastric emptying in functional dyspepsia (FD) as defined by Rome III classification. Methods We enrolled 74 patients presenting with typical symptoms of FD and 64 healthy volunteers. Gastric motility was evaluated using the 13C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms and self-rating questionnaires for depression (SRQ-D) scores to determine status of depression. The Arg51Gln (346G>A), preproghrelin (3056T>C), Leu72Met (408C>A), Gln90Leu (3412T>A) and G-protein 3 (825C>T) polymorphisms were analyzed in the DNA from blood samples of enrolled subjects. Genotyping was performed by polymerase chain reaction. Results There was a significant relationship between the Gln90Leu3412 genotype and SRQ-D score in FD patients (P = 0.009). Area under the curve at 15 minutes (AUC15) value was significantly associated with the Leu72Met408 genotype (P = 0.015) but not with entire gastric emptying. Conclusions The Leu72Met (408C>A) single nucleotide polymorphism was significantly associated with early phase of gastric emptying in FD patients. Further studies will be necessary to clarify the association between ghrelin gene single nucleotide polymorphisms and early phase of gastric emptying in FD patients.

Genotyping of Citrus Accessions with S<SUB>9</SUB> and/or S<SUB>10</SUB> Alleles for Self-incompatibility and Their Allelic Distribution

Jung-Hee Kim,Mayumi Sato,Akira Wakana,Fuka Takamatsu,Kaori Sakai,Masayoshi Shigyo,Jun-ichiro Masuda 한국원예학회 2021 원예과학기술지 Vol.39 No.6

Gametophytic self-incompatibility, one of the key characteristics for breeding seedless Citrus cultivars, occurs in pummelo (Citrus maxima), mandarin (Citrus reticulata), and their hybrid cultivars. Allelic variation in Citrus was reported for the self-incompatibility gene (S); however, S allele frequencies and S genotypes of full- and semi-self-incompatible cultivars have been reported for a small number of alleles. To extend our knowledge of S alleles, we tested 146 Citrus accessions, including 82 pummelo accessions, for S<SUB>9</SUB> and S<SUB>10</SUB> alleles. Each accession was pollinated with homozygous S₁ seedlings of ‘Hirado Buntan’ pummelo (S<SUB>9</SUB>S<SUB>9</SUB> and S<SUB>10</SUB>S<SUB>10</SUB>). The pollen tube growth arrest in the lower styles of their pollinated pistils indicated that four accessions, including ‘Hirado Buntan [Citrus maxima (Burm.) Merr.]’, have the S<SUB>9</SUB> allele and five accessions, including ‘Hirado Buntan’, have the S<SUB>10</SUB> allele. The percentage of accessions with the S<SUB>9</SUB> allele was 3.2% (4 of 126 accessions examined), and the S<SUB>9</SUB> allele frequency was 1.8% (4 of 217 alleles, excluding the S<SUB>f</SUB> allele). The percentage of accessions with the S<SUB>10</SUB> allele was 3.9% (5 of 127 accessions examined), and the S<SUB>10</SUB> allele frequency was 2.3% (5 of 217 alleles, excluding the S<SUB>f</SUB> allele). Japanese mandarin (another sources of S alleles) and its relatives had neither the S<SUB>9</SUB> nor the S<SUB>10</SUB> allele. Pummelo accessions had S<SUB>9</SUB> and S<SUB>10</SUB> alleles at higher rates of 2.9% (2 of 70 accessions examined) and 7.0% (5 of 71 accessions examined), respectively. ‘Kabusu’ sour orange (a pummelo-mandarin hybrid; Citrus aurantium) and ‘Kikudaidai’ (a sour orange relative; Citrus canaliculata) had S<SUB>9</SUB> alleles. These results suggested that the two alleles originated from pummelo (the main sources of S alleles). The S genotypes with S<SUB>9</SUB> and/or S<SUB>10</SUB> alleles were fully determined in ‘Hirado Buntan’ (S<SUB>9</SUB>S<SUB>10</SUB>), ‘Kabusu’ sour orange (S<SUB>f</SUB>S<SUB>9</SUB>), the ‘Kikudaidai’ (S<SUB>9</SUB>S<SUB>11</SUB>) sour orange hybrid, and two local pummelo plants. The results of our study suggest that in comparison with the other S alleles reported, the pummelo plants with low frequencies of S<SUB>9</SUB> and/or S<SUB>10</SUB> alleles contributed to very low rates of evolution and development of Citrus species and cultivars during the long history of citrus cultivation, except for those generating sour oranges (Citrus auratinum), which are used as root stocks, and for flesh and rind processing and ornamental plants. Finally, we examined the degree of self-incompatibility between S<SUB>9</SUB> and S<SUB>10</SUB> alleles in the lower part of styles of S₁ seedlings of ‘Hirado Buntan’ and Citrus accessions with S<SUB>9</SUB> and/or S<SUB>10</SUB> alleles. The result indicated no difference in the self-incompatibility reaction between the two alleles.

Chronic Stress Induces Neurotrophin-3 in Rat Submandibular Gland

Juri Saruta,Keiichi Tsukinoki,Michitaro Iida,Yusuke Kondo,Masahiro To,Takashi Hayashi,Mayumi Hori,Sadao Sato 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.6

Purpose: Plasma neurotrophin-3 (NT-3) levels are associated with several neural disorders. We previously reported that neurotrophins were released from salivary glands following acute immobilization stress. While the salivary glands were the source of plasma neurotrophins in that situation, the association between the expression of neurotrophins and the salivary gland under chronic stress conditions is not well understood. In the present study, we investigated whether NT-3 levels in the salivary gland and plasma were influenced by chronic stress. Materials and Methods: Expressions of NT-3 mRNA and protein were characterized, using real-time polymerase chain reactions, enzyme-linked immunosorbent assay, and immunohistochemistry,in the submandibular glands of male rats exposed to chronic stress (12 h daily for 22 days). Results: Plasma NT-3 levels were significantly increased by chronic stress (p<0.05), and remained elevated in bilaterally sialoadenectomized rats under the same condition. Since chronic stress increases plasma NT-3 levels in the sialoadenectomized rat model, plasma NT-3 levels were not exclusively dependent on salivary glands. Conclusion: While the salivary gland was identified in our previous study as the source of plasma neurotrophins during acute stress, the exposure to long-term stress likely affects a variety of organs capable of releasing NT-3 into the bloodstream. In addition, the elevation of plasma NT-3 levels may play important roles in homeostasis under stress conditions.