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- 저자 : Matz, Melissa (검색결과 9 건)
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Ethan L Matz,Amy M Pearlman,Ryan P Terlecki 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.1
Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM). Before clinical trials can be performed, safety analysis is desirable. We reviewed an initial series of patients receiving PRFM for urologic pathology to assess safety and feasibility. Materials and Methods: Data were reviewed for patients treated with PRFM at our center from November 2012 to July 2017. Patients were observed immediately post-injection and at follow-up for complications and tolerability. Where applicable, International Index of Erectile Function (IIEF-5) scores were reviewed before and after injections for ED and/or PD. Pad use data was collected pre/post injection for SUI. Results: Seventeen patients were identified, with a mean receipt of 2.1 injections per patient. Post-procedural minor adverse events were seen in 3 men, consisting of mild pain at injection site and mild penile bruising. No patients experienced complications at follow-up. No decline was observed in men completing pre/post IIEF-5 evaluations. Conclusions: PRFM appears to be a safe and feasible treatment modality in patients with urologic disease. Further placebo-controlled trials are warranted.
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the CONCORD Working Group,Matz, M.,Coleman, M.P.,Sant, M.,Chirlaque, M.D.,Visser, O.,Gore, M.,Allemani, C. Academic Press 2017 Gynecologic oncology Vol.144 No.2
Objective: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results: During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions: The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.
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the CONCORD Working Group,Matz, M.,Coleman, M.P.,Carreira, H.,Salmeron, D.,Chirlaque, M.D.,Allemani, C. Academic Press 2017 Gynecologic oncology Vol.144 No.2
Objective: Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods: The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15-99years) diagnosed with ovarian cancer during 1995-2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from 67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated age-standardised 5-year net survival by stage at diagnosis (localised or advanced). Results: Survival from type I epithelial ovarian tumours for women diagnosed during 2005-09 ranged from 40 to 70%. Survival from type II epithelial tumours was much lower (20-45%). Survival from germ cell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions: There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology.
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Internet Electronic Mail: a Viable Research Tool?
Case, Carl J.,Matz, Lizabeth A. Research Institute for Business and Entrepreneursh 1998 ASIAN JOURNAL OF BUSINESS AND ENTREPRENEURSHIP Vol.1 No.-
The purpose of this research is to examine the utility of the Internet as a method for conducting surveys. The study compared effectiveness of Internet-delivered survey versus postal-delivered instruments. The methodology involved using a survey to solicit information technology usage data. Results suggest that although response rates for Internet subjects was approximately one-half the rate for postal-delivered subjects, responses were nearly identical. However, Internet responses were obtained in a significantly shorter period of time. Overall, the study demonstrates that the Internet provides a communication vehicle which can save time and expense in obtaining research data and potentially require fewer subjects.
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Advanced Technique for Moisture Condition Assessment in Power Transformers
Cheng, Jialu,Robalino, Diego,Werelius, Peter,Ohlen, Matz The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.3
The presence of moisture in a transformer needs to be monitored throughout its service life. Moisture deteriorates transformer insulation by decreasing both electrical and mechanical strength. High moisture content accelerates solid insulation aging, reduces the breakdown strength and makes the transformer vulnerable to the overload conditions due to high temperature spot bubbling. In addition to that, partial discharge can occur in a high voltage region because of the moisture disturbance. Traditional indirect estimation of the moisture concentration in the solid insulation of power transformers includes testing the oil samples as well as measurement of the insulation resistance and loss tangent (50/60 Hz) of the transformer. However, these methods usually give limited information and may lead to wrong conclusions. Direct measurement is not viable and may not be representative to take a paper sample from the surface insulation because moisture distribution is not homogeneous along the insulation geometry. Dielectric Frequency Response, DFR was introduced more than 20 years ago and has been thoroughly evaluated and proven. Several documents have been published summarizing the research work and field tests all over the world. DFR is a practical non-intrusive and non-destructive technique for moisture condition assessment in power transformers, a breakthrough compared with traditional methods. Scientists, researchers and utility operators have shown great interest in the development and application of DFR technique. In this paper, the limitation of traditional methods is presented at first. Later, a comprehensive review of DFR method demonstrates its advantages over traditional methods. Finally, latest research about the mathematical model, temperature correction and test voltage is included to answer common questions regarding the application of DFR method.
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The role of body mass index on quality indicators following minimally-invasive radical prostatectomy
Ram A. Pathak,Robert R.A. Wilson,Timothy E. Craven,Ethan Matz,Ashok K. Hemal 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.3
Purpose: We sought to determine the role of body mass index (BMI) on quality indicators, such as length of stay and readmission. The National Surgical Quality Improvement Program (NSQIP) database was queried to examine the effect of obesity, defined as BMI >30, on outcomes after Minimally Invasive Radical Retropubic Prostatectomy (MI-RRP). Materials and Methods: Utilizing the NSQIP database, patient records were identified using the Current Procedural Terminology (CPT) code 55866 (laparoscopy, surgical prostatectomy, radical retropubic) during a 10-year period (2007–2017). Obesity was classified according to the CDC classification. Chi-square tests were utilized to evaluate BMI distribution by surgery year. Logistic regression was used to evaluate the relationship of BMI with length of stay (LOS) and hospital readmission within 30 days, after controlling for preoperative variables. Results: Records of 49,238 patients who have undergone MI-RRP during 2007–2017 were evaluated. Mean yearly BMI rose from 28.5 to 29.2, while the percentage of surgical patients with BMI >30 rose by 5% (33% to 38%; p<0.0001) over the study period. Obese patients demonstrated higher morbidity, prolonged LOS, and increased readmission rates after MI-RRP. Obesity severity correlated negatively with quality indicators in a graded fashion. Conclusions: Obesity rates in patients undergoing MI-RRP increased from 2007–2017. Obese patients are at increased risk of morbidity, prolonged LOS, and readmission within 30 days, following MI-RRP. These patients should not be excluded from MI-RRP; rather, physicians should discuss these increased risks with their patients. Proper weight loss strategies should be instituted preoperatively to mitigate these risks.
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( Jens Niklas ),( Anne Bonin ),( Stefanie Mangin ),( Joachim Bucher ),( Stephanie Kopacz ),( Madlen Matz-soja ),( Carlo Thiel ),( Rolf Gebhardt ),( Ute Hofmann ),( Klaus Mauch ) 생화학분자생물학회 2012 BMB Reports Vol.45 No.7
Overnutrition is one of the major causes of non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by an accumulation of lipids (triglycerides) in hepatocytes and is often accompanied by high plasma levels of free fatty acids (FFA). In this study, we compared the energy metabolism in acute steatotic and non-steatotic primary mouse hepatocytes. Acute steatosis was induced by pre-incubation with high concentrations of oleate and palmitate. Labeling experiments were conducted using [U-13C5,U-15N2] glutamine. Metabolite concentrations and mass isotopomer distributions of intracellular metabolites were measured and applied for metabolic flux estimation using transient 13C metabolic flux analysis. FFAs were efficiently taken up and almost completely incorporated into triglycerides (TAGs). In spite of high FFA uptake rates and the high synthesis rate of TAGs, central energy metabolism was not significantly changed in acute steatotic cells. Fatty acid β-oxidation does not significantly contribute to the detoxification of FFAs under the applied conditions. [BMB Reports 2012; 45(7): 396-401]
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