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Application of Frictional Bond-Slip Model to Large-Scale FRP-Strengthened T-Beams with U-wraps
Jaeha Lee,Maria Lopez 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.1
Studies on U-wraps generally focus on the experimental results and mechanisms of the shear strengthening effect. Only a few studies have focused on the anchoring effect of the longitudinal FRP due to addition of the U-wrap. Lee and Lopez (Constr Build Mater 194:226–237, 2016) have found experimentally from pull-out tests that incremental changes occur in the debonding strain at the concrete-FRP interface depending on the various type of U-wraps. The proposed numerical method using the Frictional Bond-Slip (FBS) model has been validated by comparing the pull-out test results (Lee and Lopez Constr Build Mater 194:226–237, 2016). In the present study, the FBS model was applied to characterize the behavior of a large scale FRP strengthened T-beam with multiple U-wraps. First, the 2-dimensional (2D) model for pull-out test was developed. Debonding load and behavior of the model were compared with both the experimental results (Lee and Lopez Constr Build Mater 194:226–237, 2016) and the simulation results of a 3-dimensional (3D) model from a previous study (Lee and Lopez Constr Build Mater 194:226-237, 2016). Next, the 2D model was applied to model the behavior of a large scale FRP strengthened T-beam with multiple U-wraps. The conducted 2D simulation using the proposed FBS model predicted well the strains at various locations on the FRP sheet, the flexural capacity and complex failure mode of the FRP strengthened beam with several U-wraps. The proposed FBS model was also applied to other comparable studies, and debonding strains were successfully predicted within an margin of error of 7%. Using the validated model, a parametric study of the FRP strengthened T-beam was conducted with various key parameters of the U-wrap, such as the angle of U-wrap and the number of U-wrap.
Tommaso Giuliani,Maria Lopez Rubio,Eva Montalva Oron,Javier Maupoey Ibanez,Andrea Bosca Robledo,Cecilia Lopez Valdivia,Judith Perez Rojas,Rafael Lopez Andujar 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.1
Indications and outcomes of extended pancreatectomies have been recently appraised by the International Study Group for Pancreatic Surgery. However, no definitive conclusions have been drawn, particularly in the setting of neoadjuvant treatments. We present here a case of 53-year-old man diagnosed with a bulky adenocarcinoma of the tail of the pancreas and infiltrating the adjacent organs and the thoracic wall. The patient was sent to neoadjuvant chemotherapy and he underwent 12 cycles of FOLFIRINOX. Since a significant radiological response was observed after chemotherapy, the patient was scheduled for extended distal pancreatectomy with en bloc resection of the thoracic wall, in order to achieve a radical resection. The surgery is herein described with all technical details. The patient was discharged after an uneventful early post-operative course and subsequently readmitted for a late grade B post-operative pancreatic fistula, which was ultimately treated successfully. Pathology showed complete response. When performed in centers with ample experience in pancreatic surgery, extended pancreatic resections represent a viable curative option with acceptable surgical outcomes. In this setting, challenging tailored resections should be considered to achieve negative margins, particularly following maximized effective downstaging strategies.
Romagnoli, Romeo,Baraldi, Pier Giovanni,Lopez-Cara, Carlota,Cruz-Lopez, Olga,Carrion, Maria Dora,Kimatrai Salvador, Maria,Bermejo, Jaime,Est?vez, Sara,Est?vez, Francisco,Balzarini, Jan,Brancale, Andre Wiley-VCH 2011 CHEMMEDCHEM Vol.6 No.10
<P>Induction of apoptosis is a promising strategy that could lead to the discovery of new molecules active in cancer chemotherapy. This property is generally observed when cells are treated with agents that target microtubules, dynamic structures that play a crucial role in cell division. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. A new class of inhibitors of tubulin polymerization based on the 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan molecular skeleton, with the amino group placed at different positions on the benzene ring, were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell-cycle effects. The methoxy substitution pattern on the benzene portion of the benzo[b]furan moiety played an important role in affecting antiproliferative activity. In the series of 5-amino derivatives, the greatest inhibition of cell growth occurred if the methoxy substituent is placed at the C6 position, whereas C7 substitution decreases potency. The most promising compound in this series is 2-(3',4',5'-trimethoxybenzoyl)-3-methyl-5-amino-6-methoxybenzo[b]furan (3 h), which inhibits cancer cell growth at nanomolar concentrations (IC(50) =16-24 nM), and interacts strongly with tubulin by binding to the colchicine site. Sub-G(1) apoptotic cells in cultures of HL-60 and U937 cells were observed by flow cytometric analysis after treatment with 3 h in a concentration-dependent manner. We also show that compound 3 h induces apoptosis by activation of caspase-3, -8, and -9, and this is associated with cytochrome c release from mitochondria. The introduction of an α-bromoacryloyl group increased antiproliferative activity with respect to the parent amino derivatives.</P>
Design of Two-Stage Class AB CMOS Buffers: A Systematic Approach
Antonio Lopez Martin,Jose Maria Algueta Algueta,Lucia Acosta,Jaime Ramirez-Angulo,Ramon Gonzalez Carvajal 한국전자통신연구원 2011 ETRI Journal Vol.33 No.3
A systematic approach for the design of two-stage class AB CMOS unity-gain buffers is proposed. It is based on the inclusion of a class AB operation to class A Miller amplifier topologies in unity-gain negative feedback by a simple technique that does not modify quiescent currents, supply requirements, noise performance, or static power. Three design examples are fabricated in a 0.5 μm CMOS process. Measurement results show slew rate improvement factors of approximately 100 for the class AB buffers versus their class A counterparts for the same quiescent power consumption (< 200 μW).
Benjamin Lopez-Jimena,Esther Garcia-Rosado,Kim Dawn Thompson,Alexandra Adams,Carlos Infante,Juan Jose Borrego,Maria del Carmen Alonso 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.4
The distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens was examined by immunohistochemistry in the nervous and non-nervous organs of juvenile European seabass (Dicentrarchus labrax) during the course of an intramuscular infection. Histological changes resulting from the infection were evaluated from 3 days to 2 months post-infection. The specific antibody response was also studied 2 months post-challenge. Viral proteins were present throughout the experimental period in the retina (inner nuclear layer, ganglion layer, outer limiting membrane, and outer plexiform layer), brain (cerebellum and tectum opticum), and liver (hepatocytes and endothelial cells). These proteins were also observed in the renal tubular cells, white pulp of spleen, and in fibroblasts and cartilage of caudal fin. This is the first report of RGNNV proteins appearing in these organs, where the immunostaining was only detected at certain sampling times after the onset of mortality. Brain and retina of virus-exposed fish showed high levels of vacuolation, while accumulation of fat vacuoles was observed in the liver. RGNNV infection also induced a specific antibody response as measured by an ELISA. In summary, this is the first study demonstrating the presence of viral proteins in cells of caudal fin, kidney and spleen of European seabass.
( Juan Carlos Lopez Alvarenga ),( William Orr ),( Jose Antonio Vargas Romero ),( Jose Maria Remes Troche ),( Miguel Morales Arambula ),( Julio Cesar Soto Perez ),( Gualberto Mateos Perez ),( Sergio So 대한소화기기능성질환·운동학회 2014 Journal of Neurogastroenterology and Motility (JNM Vol.20 No.1
Background/Aims To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra- esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. Methods Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient- completed ReQuest in PracticeTM questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms. Results Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in PracticeTM dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated. Conclusions Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present. (J Neurogastroenterol Motil 2014;20:64-73)