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Abdelaziz, Ashraf Omar,Elbaz, Tamer Mahmoud,Shousha, Hend Ibrahim,Ibrahim, Mostafa Mohamed,El-Shazli, Mostafa Abdel Rahman,Abdelmaksoud, Ahmed Hosni,Aziz, Omar Abdel,Zaki, Hisham Atef,Elattar, Inas An Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Background: Hepatocellular carcinoma (HCC) is a dismal tumor with a high incidence, prevalence and poor prognosis and survival. Management of HCC necessitates multidisciplinary clinics due to the wide heterogeneity in its presentation, different therapeutic options, variable biologic behavior and background presence of chronic liver disease. We studied the different prognostic factors that affected survival of our patients to improve future HCC management and patient survival. Materials and Methods: This study is performed in a specialized multidisciplinary clinic for HCC in Kasr El Eini Hospital, Cairo University, Egypt. We retrospectively analyzed the different patient and tumor characteristics and the primary mode of management applied to our patients. Further analysis was performed using univariate and multivariate statistics. Results: During the period February 2009 till February 2013, 290 HCC patients presented to our multidisciplinary clinic. They were predominantly males and the mean age was $56.5{\pm}7.7years$. All cases developed HCC on top of cirrhosis that was mainly due to HCV (71%). Most of our patients were Child-Pugh A (50%) or B (36.9%) and commonly presented with small single lesions. Transarterial chemoembolization was the most common line of treatment used (32.4%). The overall survival was 79.9% at 6 months, 54.5% at 1 year and 22.4% at 2 years. Serum bilirubin, site of the tumor and type of treatment were the significant independent prognostic factors for survival. Conclusions: Our main prognostic variables are the bilirubin level, the bilobar hepatic affection and the application of specific treatment (either curative or palliative). Multidisciplinary clinics enhance better HCC management.
Hadj Henni Abdelaziz,Mohamed Ait Amar Meziane,Abdelmoumen Anis Bousahla,Abdelouahed Tounsi,S.R. Mahmoud,Afaf S. Alwabli 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.25 No.6
In this research, a simple hyperbolic shear deformation theory is developed and applied for the bending, vibration and buckling of powerly graded material (PGM) sandwich plate with various boundary conditions. The displacement field of the present model is selected based on a hyperbolic variation in the in-plane displacements across the plate‟s thickness. By splitting the deflection into the bending and shear parts, the number of unknowns and equations of motion of the present formulation is reduced and hence makes them simple to use. Equations of motion are obtained from Hamilton‟s principle. Numerical results for the natural frequencies, deflections and critical buckling loads of several types of powerly graded sandwich plates under various boundary conditions are presented. The accuracy of the present formulation is demonstrated by comparing the computed results with those available in the literature. As conclusion, this theory is as accurate as other theories available in the literature and so it becomes more attractive due to smaller number of unknowns.
Ahmed El Zayat,Mahmoud Abdelaziz,Ahmed Yousry,Ismail Ibrahim 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.4
BACKGROUND: Diastolic function has been reported to be impaired in many patients with coronary slow flow phenomenon (CSFP). CSFP has broad spectrum of clinical presentations, including non-ST elevation myocardial infarction (NSTEMI). We sought to study the short-term evolution of diastolic function in CSFP patients presenting with NSTEMI. METHODS: This study included 92 patients with CSFP and acute NSTEMI. Conventional echocardiography Doppler imaging and tissue Doppler echocardiography imaging were used to evaluate diastolic function during index NSTEMI and after 3 months. RESULTS: Mean age of study patients was 45.7 ± 6.8 years. The prevalence of diastolic dysfunction (DD) at baseline was 69 patients (75%) and 28 patients (30.4%) at 3 months, p < 0.001. Various diastolic function indices showed significant improvement from baseline to 3 months follow-up. E/Em was 17.32 ± 3.41 at baseline compared to 12.41 ± 5.58 at 3 months, p = 0.039. Septal e′ velocity was 5.67 ± 4.56 cm/s at baseline compared to 7.78 ± 3.22 cm/s at 3 months, p = 0.023. Medications used were not significantly different between those with improved versus unimproved DD. CONCLUSIONS: Diastolic function seems to improve over short-term follow-up in patients with CSFP presenting with NSTEMI. This could reflect a transient worsening during acute NSTEMI.
Bahgat, Nermine Ahmed,Kamal, Manal Mohamed,Abdelaziz, Ashraf Omar,Mohye, Mohamed Ahmed,Shousha, Hend Ibrahim,ahmed, Mae Mohamed,Elbaz, Tamer Mahmoud,Nabil, Mohamed Mahmoud Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This study aimed to determine whether single nucleotide polymorphisms (SNP) in IFN- ${\gamma}$ and IL-10 genes are associated with susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN ${\gamma}$ (+874T/A) and IL-10 (-1082G/A) genotypes were determined in 75 HCV genotype 4 patients with different disease severities (chronic hepatitis, n=25, liver cirrhosis and hepatocellular carcinoma (HCC) on top of liver cirrhosis, n=50) and 25 healthy participants using allele-specific polymerase chain reaction. No statistical differences in allele or genotype distributions of IFN ${\gamma}$ and IL-10 genes were detected between patients and controls or between patientgroups. No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-${\gamma}$ at position +874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosis or HCC. In conclusion; interferon-${\gamma}$ and interleukin-10 gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C (Genotype-4).
Instability analysis of microfilaments with and without surface effects using Euler theory
Taj, Muhammad,Khadimallah, Mohamed A.,Hussain, Muzamal,Mahmood, Shaid,Safeer, Muhammad,Rashid, Yahya,Ahmad, Manzoor,Naeem, M. Nawaz,Asghar, Sehar,Ponnore, Joffin,Al Qahtani, Abdelaziz,Mahmoud, S.R.,Al Techno-Press 2021 Advances in nano research Vol.10 No.6
The study of cell components has been an active area of research since the last few decades. Cytoskeleton of the cell which gives shape and provides structure to the cell has three main components, microtubules, microfilaments and intermediate filaments. Each of the cytoskeletal components is surrounded by various filamentous or the other cytoskeletal components act as a surface layer on these filaments. The stability of these components affected when cell perform various functions in the body and as a result these filaments buckle, vibrate and bend. In the present study the buckling behavior of microfilament is discussed with the effects of surface by using Euler Bernoulli beam theory and the obtained results for free and surrounded microfilament are shown in the tables and figures.
Thermal stress effects on microtubules based on orthotropic model: Vibrational analysis
Taj, Muhammad,Khadimallah, Mohamed A.,Hussain, Muzamal,Fareed, Khurram,Safeer, Muhammad,Khedher, Khaled Mohamed,Ahmad, Manzoor,Naeem, M. Nawaz,Qazaq, Amjad,Qahtani, Abdelaziz Al,Mahmoud, S.R.,Alwabli, Techno-Press 2021 Advances in concrete construction Vol.11 No.3
Vibration of protein microtubules is investigated based upon Orthotropic Elastic Shell Model, considering the effect of thermal stresses. The complete analytical formulas of thermal vibration for microtubules are obtained. It is observed that the effects of thermal stresses on the vibrational frequency mode are more significant when the longitudinal and circumferential wave vectors are large enough. But when the length of wave vector reduces to 5 nm, these effects have no significant effects. The present results well agree with the lattice vibrations of microtubules. Moreover, the results show that the effects of thermal stresses due to small change in temperature are not so significant but with the increase in temperature its effects are obvious.