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RISS 인기검색어
- 검색키워드
- 저자 : Maged El Kemary (검색결과 5 건)
- 무료
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- 유료
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Nagi M. El-Shafai,Mohamed E. El-Khouly,Maged El-Kemary,Mohamed S. Ramadan,Aly S. Derbalah,Mamdouh S. Masoud 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Graphene oxide–titanium dioxide (GO@TiO2) nanocomposite with mean diameter size of 14 nm has been fabricated, characterized, and used as photocatalyst for degradation of two highly toxic insecticides, namely carbaryl and imidacloprid. Characterizations of GO@TiO2 have been carried out using various analytical and spectroscopic techniques. Compared to TiO2NPs, the fabricated GO@TiO2 nanocomposite has advantage of its smaller band gap. The finding that the photocatalytic degradation of the examined insecticides by the fabricated GO@TiO2 is more efficient compared to that of TiO2NPs suggests the superiority for using the fabricated GO@TiO2 nanocomposite for degradation of the examined toxic insecticides.
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Hollow Spherical Curcumin Nanomicelles CUR@PLA@PF127: A New Trial on Breast Cancer Cells
Fatma S. El-Banna,Nemany A. N. Hanafy,Magdy E. Mahfouz,Maged El Kemary 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.5
Curcumin (CUR) nanomicelles were developed by solvent-evaporation method using Poly (lactic acid) (PLA) for the first time with Pluronic F127 (PF127) to produce CUR@PLA@PF127 nanomicelles. The X-ray diffraction (XRD) spectra confirmed the encapsulation of CUR into the produced nanomicelles (CUR@PLA@PF127). Fourier transform infrared spectroscopy (FTIR) analysis showed the interactions of CUR with PLA and PF127. Scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis showed the formation of spherical shape of CUR@PLA@PF127 with a diameter around 130-160 nm. To investigate the anticancer effect of the encapsulated CUR, the activity of CUR@PLA@PF127 nanomicelles, free CUR and blank nanomicelles (PLA@PF127) were assayed against two cell lines in-vitro, human breast adenocarcinoma cells (MCF-7) and human breast skin fibroblast cells. The cytotoxicity assay of CUR@PLA@PF127 nanomicelles, revealed an IC50 value of 159.7 ± 1.36 μg/mL for MCF-7 cells which is much lower than that observed for free CUR. This result suggests that CUR@PLA@PF127 nanomicelles increased CUR potency due to improving its water solubility, resulting in longer release profile, and increasing antiproliferative effect on breast cancer cells (MCF-7). We anticipate that CUR@PLA@PF127 in drug delivery, improving drugs design and that the developed nanomicelles will be regarded one of the most promising nanocarriers for the treatment of breast cancer, and opening the door to future applications in cancer therapies.
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Manal F. Abou Taleb,Samia El-Sigeny,Maged El-Kemary 한국고분자학회 2012 Macromolecular Research Vol.20 No.4
The present work reports the effect of radiation cross-linking on aqueous solution of 4-acryloyl morpholine (ACMO)/acrylic acid (AA) in the presence of flutamide (FLT), an anticancer drug. Use of a γ-irradiation process within 5 kGy provided an insoluble hydrogel. Ultraviolet-visible absorption, fluorescence spectroscopy, and Fourier transform infrared spectroscopy were employed to study the complex formation of FLT with ACMO and AA. The ability of the prepared ACMO/AA-based hydrogels to be used as drug carriers for anticancer-specific drug delivery system was estimated using FLT as a model drug. In vitro drug release studies in a pH 7 buffer solution show that 20%-30% of the FLT was continuously released from the FLT-incorporated ACMO/AA hydrogel within 1 day, followed by a gradual release upon 7 days under in vitro non-degradation hydrogel conditions. The recognition affinity of the ACMO/AA/FLT hydrogel is increased when synthesized in a high-concentration template solution.
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Nehal Salahuddin,Ebtisam Mohamed Ibrahim,Maged El Kemary 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
The development of a facile method for preparing electrospun artesunate-loaded inorganic/organic compositenanofiber drug delivery systems will significantly enhance the therapeutic applications of artesunate as a novel anticancermedication. Herein, artesunate- loaded citrate-functionalized hydroxyapatite nanorods (ART@Cit-HAp NRs) were prepared,and then encapsulated into PLA nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) via the electrospinningmethod. The produced Cit-HAp NRs, ART@Cit-HAp NRs and ART@Cit-HAp NRs/PLA composite nanofibers werecharacterized using a variety of comprehensive techniques. Electrospun PLA nanofibers have a smooth surface and ahomogeneous diameter without any grains on the surface. The as-prepared citrate functionalized hydroxyapatite nanorodsshowed the high drug-loading efficiency of ~92 %. The mechanism of pseudo-second-order adsorption is the most prominentmodel for ART adsorption on Cit-HAp NRs. The in vitro ART release from the composite nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) was investigated and compared to ART@Cit-HAp NRs under different pH conditions. The ARTreleased from the ART@Cit-HAp NRs/PLA composite nanofibers in a sustained, slow rate was in contrast to Cit-HAp NRsand dependent on the pH of the medium. The in vitro antitumor activity of nanoformulations were evaluated on two coloncancer (CaCo-2 and HCT 116) cell lines. The findings revealed that ART@Cit-HAp NRs/PLA composite nanofibersdemonstrated higher anti-proliferating activity compared to free ART, and the pH-triggered release of ART@Cit-HAp NRs/PLA composite nanofibers are interesting prospects for colon cancer treatment.
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Ahmed Magdy,Emad Sadaka,Nemany Hanafy,Mohammed A. El‑Magd,Nasr Allahloubi,Maged El Kemary 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert oxidative stress-based adverse effects on normal cells and so their applications have raised concern about possible health and environmental risks. Objective We evaluated whether green tea extract (GTE), which contains potent antioxidants, could ameliorate AgNPs geno-, cyto-, and histotoxicities without decreasing their therapeutic potential against Ehrlich ascetic carcinoma (EAC). Results GTE enhanced the anti-cancer effect of AgNPs against EAC cells and ameliorated the genotoxic effect of AgNPs as indicated by lowering chromosomal aberrations and micronucleus frequencies. Additionally, GTE relieved most of degenerative histological changes induced by AgNPs. GTE restored the increased MDA and the decreased SOD, GPx and CAT serum levels induced by AgNPs to levels comparable to normal. The pre-treatment with GTE and AgNPs showed better improvement than the post-treatment strategy. Conclusions GTE can not only ameliorate AgNPs-induced adverse effects but also improve their anti-cancer effect against EAC. So, it could be useful in the treatment of liver dysfunction associated with AgNPs.
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