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History - Dependent Coupled Growth of Creep Damage under Variable Stress Conditions
Kawai, M . 대한금속재료학회(대한금속학회) 1998 METALS AND MATERIALS International Vol.4 No.4
A multiaxial constitutive model is presented for the description of the history-dependent inelastic and damage behavior of polycrystalline metallic materials in the high-temperature range under variable loading conditions. A particular emphasis is placed on a new formulation for the history-dependent material degradation which is based on a coupling between hardening and damage. The total damage is given by the sum of damage components which have different history dependence. The associated continuum damage variables are defined through their evolution equations coupled with hardening parameters involved with a kinematic hardening model. The non-classical coupling between hardening and damage is incorporated into the modified kinematic hardening model which hay, been developed for describing the complicated hardening and softening behavior under repeated stress changes. Numerical simulations for different material parameters show that the proposed damage-coupled constitutive model can predict an acceleration as well as a deceleration of creep damage. growth due to stress variations.
Kawai, M.,Zhang, J.Q.,Saito, S.,Xiao, Y.,Hatta, H. The Korean Society for Composite Materials 2009 Advanced composite materials Vol.18 No.3
Off-axis compressive deformation behavior of a unidirectional CFRP laminate at high temperature and its strain-rate dependence in a quasi-static range are examined for various fiber orientations. By comparing the off-axis compressive and tensile behaviors at an equal strain rate, the effect of different loading modes on the flow stress level, rate-dependence and nonlinearity of the off-axis inelastic deformation is elucidated. The experimental results indicate that the compressive flow stress levels for relatively larger off-axis angles of $30^{\circ}$, $45^{\circ}$ and $90^{\circ}$ are about 50 percent larger than in tension for the same fiber orientations, respectively. The nonlinear deformations under off-axis tensile and compressive loading conditions exhibit significant strain-rate dependence. Similar features are observed in the fiber-orientation dependence of the off-axis flow stress levels under tension and compression and in the off-axis flow stress differential in tension and compression, regardless of the strain rate. A phenomenological theory of viscoplasticity is then developed which can describe the tension-compression asymmetry as well as the rate dependence, nonlinearity and fiber orientation dependence of the off-axis tensile and compressive behaviors of unidirectional composites in a unified manner. It is demonstrated by comparing with experimental results that the proposed viscoplastic constitutive model can be applied with reasonable accuracy to predict the different, nonlinear and rate-dependent behaviors of the unidirectional composite under off-axis tensile and compressive loading conditions.
Yahaya, M.S.,Kawai, M.,Takahashi, J.,Matsuoka, S. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.2
This study determined the influence of moisture, ensiling time and their interactions on the losses of hemicellulose and cellulose during ensiling of orchardgrass. Orchardgrass containing 80 (HM), 70 (MM) and 55% (LM) moisture was ensiled in 3 laboratory silos of 500 ml capacity for 3, 7, 21 and 91 days. The dry matter (DM), water-soluble carbohydrates (WSC), hemicellulose and cellulose contents of the ensiled orchardgrass was lowered than that of the untreated grass regardless of moisture content. Ensiling orchardgrass for 91 days (d) decreased (p<0.01) hemicellulose contents from 19 to 15%, 20 to 15% and 18 to 12% and cellulose from 31 to 29%, 29 to 26% and 27 to 26% for LM, MM and HM silage, respectively. Results from fermentation of LM and MM silages were within acceptable guidelines except for butyric acid and ammonia after 3 weeks of ensiling of MM which appeared to be lower than ideal. The results of the fermentation of HM silages were poor showing higher concentration of acetic, propionic and butyric acids and traces of isovaleric, valeric and caproic acids with ammonia at all stage of time. While the DM losses from LM and MM silages over the ensiling period were acceptable, that for HM silage increased to 13% after 91 d ensiling, confirming a poor fermentation process occurred. The greatest WSC losses occurred within 7 d of ensiling and the lowest losses occurred after 3 weeks of ensiling. Except in HM silage, the hemicellulose and cellulose losses were highest (p<0.01) in the first 3 weeks of ensiling. Hemicellulose losses were between 19 and 22% and 4.2 and 5.9% up to 3 weeks and after 3 weeks of ensiling LM and MM silages, respectively. Cellulose losses were small. In contrast, hemicellulose losses after 3 weeks of ensiling of HM silage was about 50% higher than over the first 3 weeks possibly due to clostridial type fermentation. The results showed that increasing ensiling time of high moisture orchardgrass would result in the excessive losses of DM, WSC, hemicellulose and cellulose in the silage.
Yahaya, M.S.,Kimura, A.,Harai, J.,Nguyen, H.V.,Kawai, M.,Takahashi, J.,Matsuoka, S. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.12
The evaluation of structural carbohydrate losses and its effect on silages digestibility in alfalfa (Medicago sativa L.) and orchardgrass (Dactylis glomerata L.) was studied during 5, 21 and 56 days ensiling. About 70 and 60 kg fresh matter of the two forages were ensiled in 9 silos of 120 L capacity. The digestion trials were conducted in two phases using the two grasses in two $4{\times}4$ Latin square design according to the four treatments being the grass and the three silages. There were no differences in the DM and CP contents resulting from 5 to 56 days ensiling in both forages. The water-soluble carbohydrates (WSC), hemicelllose, pectin, and energy were slightly reduced and appeared lower in 56 days silage. The ether extract and cellulose contents slightly increased as the ensiling process advanced in the two species. Hemicellulose losses of 29 and 41 g/kg DM were obtained in alfalfa and orchardgrass, respectively, 56 days after ensiling. While the cellulose losses in both species were very little, compared to that for hemicellulose, the pectin losses, 56 days after ensiling were 15 and 12 g/kg DM in alfalfa and orchardgras respectively. The total structural carbohydrates lost (ie., hemicellulose + cellulose + pectin) in g/kg DM of fresh material forage ensiled, is about four fifths the amount lost by WSC, in alfalfa and about two thirds, in orchardgrass, by 21 days ensiling after the activity of microorganism terminated, indicating that appreciable amount was used as substrate for silage fermentation. Ensiling alfalfa and orchardgrass for 0, 5, 21 and 56 days maintained a decreasing trend of 83.8, 82.5, 79.3 and 78.9% digestibility in alfalfa and 80.5, 77.0, 77.1 and 76.4% digestibility in orchardgrass. While the digestibility of cellulose and ether extract increased in silage in both species, the digestible energy values in silage were reduced from 2.6 to 2.3 and 2.9 to 2.7 Mcal/kg DM respectively in alfalfa and orchard during 5-56 days ensiling.
Ueta, M.,Sawai, H.,Shingaki, R.,Kawai, Y.,Sotozono, C.,Kojima, K.,Yoon, K. C.,Kim, M. K.,Seo, K. Y.,Joo, C. K. Springer Science + Business Media 2017 Journal of human genetics Vol.62 No.4
<P>A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16. This study might suggest the usefulness of GWAS using the ethnicity-specific array and genome-wide imputation based on large-scale whole-genome sequences. Our findings contribute to the understanding of genetic predisposition to CM-SJS with SOC.</P>
Kee, H J,Kim, J-R,Joung, H,Choe, N,Lee, S E,Eom, G H,Kim, J C,Geyer, S H,Jijiwa, M,Kato, T,Kawai, K,Weninger, W J,Seo, S B,Nam, K-I,Jeong, M H,Takahashi, M,Kook, H Macmillan Publishers Limited 2012 Cell death and differentiation Vol.19 No.1
Skeletal myogenesis is precisely regulated by multiple transcription factors. Previously, we demonstrated that enhancer of polycomb 1 (Epc1) induces skeletal muscle differentiation by potentiating serum response factor (SRF)-dependent muscle gene activation. Here, we report that an interacting partner of Epc1, ret finger protein (RFP), blocks skeletal muscle differentiation. Our findings show that RFP was highly expressed in skeletal muscles and was downregulated during myoblast differentiation. Forced expression of RFP delayed myoblast differentiation, whereas knockdown enhanced it. Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal α-actin promoter, binding of SRF to the serum response element, and muscle-specific gene induction were blocked by RFP. RFP interfered with the physical interaction between Epc1 and SRF. Muscles from rfp knockout mice (Rfp<SUP>−/−</SUP>) mice were bigger than those from wild-type mice, and the expression of SRF-dependent muscle-specific genes was upregulated. Myotube formation and myoblast differentiation were enhanced in Rfp<SUP>−/−</SUP> mice. Taken together, our findings highlight RFP as a novel regulator of muscle differentiation that acts by modulating the expression of SRF-dependent skeletal muscle-specific genes.
Nguyen, H.V.,Kawai, M.,Takahashi, J.,Matsuoka, S. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.9
The effect of various moisture contents of fresh forage on the change in nitrogen (N) fractions, in vitro ruminal N degradability, and the subsequent N utilization of silage in sheep were evaluated. Orchardgrass (Dactylis glomerata L.) with high (HM, 76%), medium (MM, 65%) and low (LM, 40%) moisture contents were ensiled into silos of 120 L capacity for 120 days. A nitrogen balance trial was conducted using a 4${\times}$4 Latin square design consisting of four dietary treatments (i.e. fresh forage, HM, MM and LM silages) and four wethers. With respect to N fractions, fraction 1 (buffer solution soluble N), fraction 2 (buffer solution insoluble N-neutral detergent insoluble N), fraction 3 (neutral detergent insoluble N-acid detergent insoluble N), and fraction 4 (acid detergent insoluble N) were determined. The proportion of fraction 1 in silages tended to decrease, while the in vitro ruminal degradability of insoluble N increased (p<0.05) with lower moisture contents at ensiling. Consequently, nitrogen utilization in sheep tended to improve as the moisture content of ensiled grass was decreased, with a negative correlation (p<0.01) between urinary N and the in vitro ruminal degradability of insoluble N. The averaged N retentions for HM, MM, and LM silage treatments were 59, 73 and 79% of that for fresh forage, respectively.