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Ban M,Kassab,Hoda H,Hussein,Omayma M,Mahmoud,Gamal Abdel-Alrahman 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.2
Gestational diabetes mellitus is one of common medical complications of pregnancy. Hyperglycemia in utero impairs renal development and produces renal anomalies. Metformin has antioxidant properties and better glycemic control. Aim: assessment insulin and metformin effects on renal development of streptozotocin-induced gestational diabetic albino rats. Sixty virgin female albino rats were used. Once pregnancy confirmed, animals were randomly assigned into control, metformin, diabetic, diabetic plus insulin, diabetic plus metformin and diabetic plus insulin and metformin treated groups. Rats were sacrificed on the 20th day of gestation; fetuses were extracted and weighted. Fetal kidneys were extracted prepared for light, morphometric and electron microscopic examination. Diabetic followed by diabetic plus metformin treated groups revealed retardation of glomerular development in the cortical and Juxtaglomerular zones with a significant increase in the early immature glomerular stages and immature to mature glomerular ratio compared to other groups. Diabetic group also showed morphometric changes, shrunken and empty glomeruli, vacuolar degeneration and hemorrhage. Diabetic plus metformin group showed minimal improvement while diabetic plus insulin and diabetic plus insulin and metformin groups showed developmental, histopathological and morphometric improvement with best results in the combination group. Gestational diabetes mellitus (GDM) possess deleterious effects on fetal kidney development. Insulin improves the glycemic state and decreases GDM effects on fetal kidneys. Metformin produces mild protection while the combination of insulin and metformin produces the best glycemic control and protect fetal kidneys.
Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro
Lee, M.,Ban, J.J.,Kim, K.Y.,Jeon, G.S.,Im, W.,Sung, J.J.,Kim, M. Academic Press 2016 Biochemical and biophysical research communication Vol.479 No.3
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that involves the death of motor neurons in the cortex, brain stem, and spinal cord. Adipose-derived stem cells (ADSCs) are considered as a perspective remedy for therapy of neurodegenerative diseases including ALS. Stem cells secrete various factors which can modulate a hostile environment, called paracrine effect. Exosomes are small extracellular vesicles containing cell derived factors and mediate paracrine effect of cells. Thus, exosomes from ADSCs (ADSC-exo) can be a potential candidate of therapeutic effects of stem cells. To investigate the effect of ADSC-exo on the cellular phenotypes of ALS, we used neuronal stem cells (NSCs), which can be differentiated into neuronal cells, isolated from wild type or G93A ALS mice model. ADSC-exo was treated to neuronal cells from G93A ALS mice model. Immunocytochemistry and dot-blot assay result showed that ADSC-exo alleviated aggregation of superoxide dismutase 1 (SOD1). Reduction of cytosolic SOD1 level by ADSC-exo was also confirmed by western blot. Mitochondria display various abnormalities in ALS and the decrease of phospho-CREB and PGC-1α were observed in the G93A cells. ADSC-exo treatment showed normalization of phospho-CREB/CREB ratio and PGC-1α expression level. Our results suggest that ADSC-exo modulates cellular phenotypes of ALS including SOD-1 aggregation and mitochondrial dysfunction, and can be a therapeutic candidate for ALS.
Search for the rare decay of ψ(3686)→Λc+p¯e+e−+c.c. at BESIII
Ablikim, M.,Achasov, M. N.,Ahmed, S.,Albrecht, M.,Alekseev, M.,Amoroso, A.,An, F. F.,An, Q.,Bai, J. Z.,Bai, Y.,Bakina, O.,Baldini Ferroli, R.,Ban, Y.,Begzsuren, K.,Bennett, D. W.,Bennett, J. V.,Berger American Physical Society 2018 Physical review. D Vol.97 No.9
<P>Based on a data sample of (448.1 +/- 2.9) x 10(6)Psi(3686) decays collected with the BESIII experiment, a search for the flavor changing neutral current transition Psi(3686) -> Lambda(+)(c) pe(+) e(-) + c.c. is performed for the first time. No signal candidates are observed and the upper limit on the branching fraction of Psi(3686) -> Lambda(+)(c) pe(+) e(-) is determined to be 1.7 x 10(-6) at the 90% confidence level. The result is consistent with expectations from the standard model, and no evidence for new physics is found.</P>
Measurement of theWboson mass with the D0 detector
Abazov, V. M.,Abbott, B.,Acharya, B. S.,Adams, M.,Adams, T.,Agnew, J. P.,Alexeev, G. D.,Alkhazov, G.,Alton, A.,Andeen, T.,Askew, A.,Atkins, S.,Augsten, K.,Avila, C.,Badaud, F.,Bagby, L.,Baldin, B.,Ban American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.1