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New Relationships involving the Mean Curvature of Slant Submanifolds in $S$-space-forms
Luis M. Fern\'{a}ndez,Mar\'{\i}a Bel\'{e}n Hans-Uber 대한수학회 2007 대한수학회지 Vol.44 No.3
Relationships between the Ricci curvature and the squared meancurvature and between the shape operator associated with the meancurvature vector and the sectional curvature function for slantsubmanifolds of an S-space-form are proved, particularizing themto invariant and anti-invariant submanifolds tangent to thestructure vector fields.
Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
Sonia Ávila-Arroyo,Gema Santamaría Nuñez,Luis Francisco García-Fernández,Carlos M. Galmarini 한국유방암학회 2015 Journal of breast cancer Vol.18 No.4
Purpose: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP) activity with trabectedin and PARP inhibitors, respectively, and whether the synthetic lethality effect had the potential for a synergistic effect in breast cancer cell lines. Additionally, we investigated if this approach remained effective in BRCA1-positive breast tumor cells. Methods: We have evaluated the in vitro synergistic effect of combinations of trabectedin and three different PARP inhibitors (veliparib, olaparib, and iniparib) in four breast cancer cell lines, each presenting a different BRCA1 genetic background. Antiproliferative activity, DNA damage, cell cycle perturbations and poly(ADP-ribosyl)ation were assessed by MTT assay, comet assay, flow cytometry and western blot, respectively. Results: The combination of trabectedin and olaparib was synergistic in all the breast cancer cell lines tested. Our data indicated that the synergy persisted regardless of the BRCA1 status of the tumor cells. Combination treatment was associated with a strong accumulation of double-stranded DNA breaks, G2/M arrest, and apoptotic cell death. Synergistic effects were not observed when trabectedin was combined with veliparib or iniparib. Conclusion: Collectively, our results indicate that the combination of trabectedin and olaparib induces an artificial synthetic lethality effect that can be used to kill breast cancer cells, independent of BRCA1 status.
Bursectomy, Curettage, and Chemotherapy in Tuberculous Trochanteric Bursitis
Luis R. Ramos-Pascua,José A. Carro-Fernández,José A. Santos-Sánchez,Paula Casas Ramos,Luis J. Díez-Romero,Francisco M. Izquierdo-García 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.1
We presented three patients with trochanteric tuberculosis and described the clinical and imaging findings of the infection. Histology revealed a necrotizing granulomatous bursitis and microbiology confirmed tuberculosis. All cases were successfully treated with bursectomy and curettage of the trochanteric lesion and antituberculous chemotherapy including isoniazid, pyrazinamide, rifampicin, and ethambutol.
Sonographic measure techniques of fetal penile length
( Álvaro López Soto ),( Jose Luis Meseguer González ),( Rocío López-perez ),( Mónica Lorente Fernández ),( Juan Martínez-uriarte ),( Olivia García Izquierdo ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.5
Postnatal penile length is a reliable, standardized, and widely used marker for the diagnosis of genitourinary pathology, as well as genetic and hormonal disorders. In contrast, prenatal diagnosis has not been developed equally and there is a lack of relevant literature. Our objective is to review the studies on fetal penile length, and apply findings to clinical practice. Although the most used technique is the outer penile length, there is no consensus regarding the appropriate technique for prenatal measurement. Several reports have provided reference data with high correlation. However, important issues like poor correlation with post-natal measures or presence of confounding variables are still present. Diagnosis of both a micropenis and macropenis can indicate related pathologies, and this information may benefit parental counseling and facilitate fetal management. Therefore, it is necessary to carry out prospective studies that provide reliable normative data.
Sonographic evaluation of fetal scrotum, testes and epididymis
( Álvaro López Soto ),( Jose Luis Meseguer González ),( María Velasco Martínez ),( Rocío López Pérez ),( Inmaculada Martínez Rivero ),( Mónica Lorente Fernández ),( Olivia García Izquierdo ),( Juan Pe 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.5
External male genitalia have rarely been evaluated on fetal ultrasound. Apart from visualization of the penis for fetal sex determination, there are no specific instructions or recommendations from scientific societies. This study aimed to review the current knowledge about prenatal diagnosis of the scrotum and internal structures, with discussion regarding technical aspects and clinical management. We conducted an article search in Medline, EMBASE, Scopus, Google Scholar, and Web of Science databases for studies in English or Spanish language that discussed prenatal scrotal pathologies. We identified 72 studies that met the inclusion criteria. Relevant data were grouped into sections of embryology, ultrasound, pathology, and prenatal diagnosis. The scrotum and internal structures show a wide range of pathologies, with varying degrees of prevalence and morbidity. Most of the reported cases have described incidental findings diagnosed via striking ultrasound signs. Studies discussing normative data or management are scarce.