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( Shuai Liu ),( Xiao Yu ),( Qiankun Wang ),( Zhepeng Liu ),( Qiaoqiao Xiao ),( Panpan Hou ),( Ying Hu ),( Wei Hou ),( Zhanqiu Yang ),( Deyin Guo ),( Shuliang Chen ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.10
The synergistic activation mediator (SAM) system can robustly activate endogenous gene expression by a single-guide RNA. This transcriptional modulation has been shown to enhance gene promoter activity and leads to epigenetic changes. Human interferon-γ is a common natural glycoprotein involved in antiviral effects and inhibition of cancer cell growth. Large quantities of high-purity interferon-γ are important for medical research and clinical therapy. To investigate the possibility of employing the SAM system to enhance endogenous human interferon-γ with normal function in innate immunity, we designed 10 single-guide RNAs that target 200 bp upstream of the transcription start sites of the interferon-γ genome, which could significantly activate the interferon-γ promoter reporter. We confirmed that the system can effectively and highly activate interferon-γ expression in several humanized cell lines. Moreover, we found that the interferon-γ induced by the SAM system could inhibit tumorigenesis. Taken together, our results reveal that the SAM system can modulate epigenetic traits of non-immune cells through activating interferon-γ expression and triggering JAK-STAT signaling pathways. Thus, this strategy could offer a novel approach to inhibit tumorigenesis without using exogenous interferon-γ.
Qiankun Zhu,Mengli Zhu,Gaotao Fan,Jiaxin Zou,Peichun Feng,Zubi Liu,Wanjun Wang 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.1
Coptis chinensis 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase (HOMT), an essential enzyme in the berberine biosynthetic pathway, catalyzes the methylation of 3'-hydroxy-N-methylcoclaurine (HMC) producing reticuline. A 3D model of HOMT was constructed by homology modeling and further subjected to docking with its ligands and molecular dynamics simulations. The 3D structure of HOMT revealed unique structural features which permitted the methylation of HMC. The methylation of HMC was proposed to proceed by deprotonation of the 4'-hydroxyl group via His257 and Asp258 of HOMT, followed by a nucleophilic attack on the SAM-methyl group resulting in reticuline. HOMT showed high substrate specificity for methylation of HMC. The study evidenced that Gly117, Thr312 and Asp258 in HOMT might be the key residues for orienting substrate for specific catalysis.
Zhu, Qiankun,Zhu, Mengli,Fan, Gaotao,Zou, Jiaxin,Feng, Peichun,Liu, Zubi,Wang, Wanjun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.1
Coptis chinensis 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase (HOMT), an essential enzyme in the berberine biosynthetic pathway, catalyzes the methylation of 3'-hydroxy-N-methylcoclaurine (HMC) producing reticuline. A 3D model of HOMT was constructed by homology modeling and further subjected to docking with its ligands and molecular dynamics simulations. The 3D structure of HOMT revealed unique structural features which permitted the methylation of HMC. The methylation of HMC was proposed to proceed by deprotonation of the 4'-hydroxyl group via His257 and Asp258 of HOMT, followed by a nucleophilic attack on the SAM-methyl group resulting in reticuline. HOMT showed high substrate specificity for methylation of HMC. The study evidenced that Gly117, Thr312 and Asp258 in HOMT might be the key residues for orienting substrate for specific catalysis.
Shao Qiankun,Zhu Qingjun,Wang Yuling,Kuang Shaobao,Bao Jie,Liu Songlin 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.6
The purpose of this study is to develop a high-energy neutron shielding material applied in proton therapy environment. Composite shielding material consisting of 10.00 wt% boron carbide particles (B4C), 13.64 wt% surface-modified cross-linked polyethylene (PE), and 76.36 wt% tungsten particles were fabricated by hotpressure sintering method, where the optimal ratio of the composite is determined by the shielding effect under the neutron field generated in typical proton therapy environment. The results of Differential Scanning Calorimetry measurements (DSC) and tensile experiment show that the composite has good thermal and mechanical properties. In addition, the high energy-neutron shielding performance of the developed material was evaluated using cyclotron proton accelerator with 100 MeV proton. The simulation shows a 99.99% decrease in fast neutron injection after 44 cm shielding, and the experiment result show a 99.70% decrease. Finally, the shielding effect of replacing part of the shielding material of the proton therapy hall with the developed material was simulated, and the results showed that the total neutron injection decreased to 0.99‰ and the neutron dose reduced to 1.10‰ before the enhanced shielding. In summary, the developed material is expected to serve as a shielding enhancement material in the proton therapy environment.
Task Offloading of Intelligent Building Based on CO–HHO Algorithm in Edge Computing
Yi Lingzhi,Gao Xieyi,Li Zongpin,Feng Xiaodong,Huang Jianxiong,Liu Qiankun 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6
With the rapid development of intelligent devices, the intelligence of buildings is becoming more and more obvious, which leads to the rapid growth of data generated by building users. The existing network bandwidth is far from enough for the transmission of existing data, which will lead to congestion in the process of data transmission. In this paper, a task offl oading strategy based on edge computing is proposed. The edge server is deployed near the data source, which mainly solves the problems of transmission delay and energy consumption of building users during task offl oading. In this paper, the mathematical model of system delay and energy consumption is established fi rst. In order to better refl ect the quality of the system, the delay and energy consumption are combined into system utility, and then the objective function is established. Since the objective function is a mixed integer nonlinear programming problem, fi nding the optimal solution usually requires exponential time complexity. Therefore, this paper fi rstly uses the Tammer decomposition method to decouple the objective function, and decomposes it into the resource allocation problem of fi xed task offl oading decision and the task offl oad problem of maximizing the objective function. Then the convex optimization (CO) theory is used to greatly reduce the complexity of the objective function and optimize the resource allocation problem. Finally, the task offl oading problem is solved by the improved Harris Hawks Optimization (HHO) . The paper compares various offl oading schemes. The simulation results show that the CO–HHO offl oading strategy based on edge computing proposed in this paper can eff ectively reduce the transmission delay and energy consumption of user tasks in intelligent buildings, and is superior to others in all aspects.