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- 저자 : Liu Hongchun (검색결과 5 건)
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Wu Hao,Liu Hongchun,Liu Haining,Chen Yanjie,Liu Taotao,Shen Xizhong,Liu Lili 한국유전학회 2022 Genes & Genomics Vol.44 No.5
Background: Differential diagnosis of Crohn's disease (CD) and intestinal tuberculosis (ITB) is still difficult in clinical pratice. DNA methylation has been considered as a favorable area for biomarker exploration and identification. Objective: The purpose of the current study was to evaluate DNA methylation changes between CD and ITB. Methods: We performed a genome-wide association study to identify differentially methylated positions (DMPs), including 8 CD patients (before the initial of biologics or immunomodulators), 6 ITB patients, and 8 healthy controls (HCs), in whole blood DNA using the Infinium HumanMethylation850 BeadChip. Results: Patients in the CD group and ITB group were all observed with hypo-methylated changes compared with HCs. However, the CD group overlaps with the ITB group in DNA methylation, suggesting a stable epigenetic profile between the two diseases. The pathway enrichment analysis showed the alternation in inflammation-related pathway, immune system, and signal transduction. Focused on the DMPs located in the promoter region, further analysis indicated hypermethylation of cg03122532 (5'UTR of KCNJ15) could be a potential CD-specific biomarker. Conclusions: We identified specific differential methylation loci related to CD and ITB in blood DNA. DNA metylation as a important epigenetic modification could contribute to the pathogenesis study and biomarker exploration of the diseases.
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Zhu Hongchun,Lv Shihong,Yang Baijing,Liu Zhuoxi,Zhang Dan 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4
Increasing evidence demonstrates that circular RNA (circRNA) plays a pivotal role in the development of disease, especially in Cancer. A previous circRNA microarray study showed that circGAK (hsa_circ_0005830) was remarkably down-regulated in hepatocellular carcinoma (HCC) tissues. However, the role of circGAK in HCC remains largely unclear. The candidate circRNAs were screened via integrating the Gene Expression Omnibus (GEO) database (GSE164803) analysis with the online program GEO2R. Quantitative real-time PCR (qRT-PCR) was employed to measure the expression of circGAK miR-1323, and hedgehog-interacting protein (HHIP) in HCC tissues and cells. The biological function of circGAK in HCC was examined using colony formation assay, 5-ethynyl-2'-deoxyuridine (EdU) assay, wound healing assay, transwell cell invasion assay, endothelial tubular formation assay, western blot assay, and xenograft mouse model. Bioinformatics analysis, RNA immunoprecipitation (RIP) assay, and dual-luciferase reporter assay were utilized to test the interaction between miR-1323, and circGAK or HHIP. The expression of circGAK was abnormally down-regulated in HCC tissues and was associated with the tumor-node-metastasis (TNM) stage. Overexpression of circGAK remarkably impeded HCC cell proliferation, migration, invasion, and endothelial tube formation in vitro, and tumor growth in vivo. Bioinformatics predicted that circGAK interacted with miR-1323, which targeted the HHIP mRNA 3'untranslated regions (UTR). Furthermore, upregulation of miR-1323 or shRNA-mediated HHIP suppression could recover circGAK-mediated malignant behaviors of HCC cells and tube formation of endothelial cells. Taken together, the circGAK/miR-1323/HHIP axis could suppress the progression of HCC and may provide potential new targets for the diagnosis and therapy of HCC.
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He, Qingming,Zhang, Yijun,Liu, Zhouyu,Cao, Liangzhi,Wu, Hongchun Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.2
A new task of using the Jacobian-Free-Newton-Krylov (JFNK) method for the PWR core transient simulations involving neutronics, thermal hydraulics and mechanics is conducted. For the transient scenario of PWR, normally the Picard iteration of the coupled coarse-mesh nodal equations and parallel channel TH equations is performed to get the transient solution. In order to solve the coupled equations faster and more stable, the Newton Krylov (NK) method based on the explicit matrix was studied. However, the NK method is hard to be extended to the cases with more physics phenomenon coupled, thus the JFNK based iteration scheme is developed for the nodal method and parallel-channel TH method. The local gap conductance is sensitive to the gap width and will influence the temperature distribution in the fuel rod significantly. To further consider the local gap conductance during the transient scenario, a 1D mechanics model is coupled into the JFNK scheme to account for the fuel thermal expansion effect. To improve the efficiency, the physics-based precondition and scaling technique are developed for the JFNK iteration. Numerical tests show good convergence behavior of the iterations and demonstrate the influence of the fuel thermal expansion effect during the rod ejection problems.
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Scattering Correction for Image Reconstruction in Flash Radiography
LIANGZHI CAO,Mengqi Wang,Hongchun Wu,Zhouyu Liu,Yuxiong Cheng,Hongbo Zhang 한국원자력학회 2013 Nuclear Engineering and Technology Vol.45 No.4
Scattered photons cause blurring and distortions in flash radiography, reducing the accuracy of image reconstruction significantly. The effect of the scattered photons is taken into account and an iterative deduction of the scattered photons is proposed to amend the scattering effect for image restoration. In order to deduct the scattering contribution, the flux of scattered photons is estimated as the sum of two components. The single scattered component is calculated accurately together with the uncollided flux along the characteristic ray, while the multiple scattered component is evaluated using correction coefficients pre-obtained from Monte Carlo simulations.The arbitrary geometry pretreatment and ray tracing are carried out based on the customization of AutoCAD. With the above model, an Iterative Procedure for image restORation code, IPOR, is developed. Numerical results demonstrate that the IPOR code is much more accurate than the direct reconstruction solution without scattering correction and it has a very high computational efficiency.
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SCATTERING CORRECTION FOR IMAGE RECONSTRUCTION IN FLASH RADIOGRAPHY
Cao, Liangzhi,Wang, Mengqi,Wu, Hongchun,Liu, Zhouyu,Cheng, Yuxiong,Zhang, Hongbo Korean Nuclear Society 2013 Nuclear Engineering and Technology Vol.45 No.4
Scattered photons cause blurring and distortions in flash radiography, reducing the accuracy of image reconstruction significantly. The effect of the scattered photons is taken into account and an iterative deduction of the scattered photons is proposed to amend the scattering effect for image restoration. In order to deduct the scattering contribution, the flux of scattered photons is estimated as the sum of two components. The single scattered component is calculated accurately together with the uncollided flux along the characteristic ray, while the multiple scattered component is evaluated using correction coefficients pre-obtained from Monte Carlo simulations.The arbitrary geometry pretreatment and ray tracing are carried out based on the customization of AutoCAD. With the above model, an Iterative Procedure for image restORation code, IPOR, is developed. Numerical results demonstrate that the IPOR code is much more accurate than the direct reconstruction solution without scattering correction and it has a very high computational efficiency.
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