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( Ha Phuong Linh ),( Hoang Van Tiep ),( Dinh Cong Dang ),( Nguyen Khac Hung Manh ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Background: Tenofovir disoproxil fumarate (TDF) is one of the first optimal choices to be used in the treatment of chronic hepatitis B. FibroScan is non-invasive methods to assess liver fibrosis. Aims: To evaluate the therapeutic effect of TDF on fibrosis via FibroScan after treatment. Methods: This study was conducted in 63 chronic hepatitis B patients who had the indication of antiviral therapy at 103 Cam Khe Clinic from March 2019 to March 2020. All patients with chronic hepatitis B treated with TDF during 6 months. Liver fibrosis stages was appreciated using transient hepatic elastography by Fibroscan before and after 6 months treatment. Results: The average age of patients was 46 years, with men accounted for 69% of the total. After treatment, normalization of ALT 71.26%, viral response of 90.23%, HBV DNA below the detection level was 66.3%. Liver fibrosis evaluated by FibroScan before and after 6 months treatment were 7.15 ± 1.56 kPa, and 3.58 ± 1.19 kPa eveluated by FibroScan. Conclusions: TDF was effective for patients after treatment on liver fibrosis assessed by FibroScan in chronic hepatitis B patients.
( Ha Phuong Linh ),( Hoang Van Tiep ),( Dinh Cong Dang ),( Nguyen Khac Hung Manh ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Chronic hepatitis C is a major infectious disease which is mainly cause of morbidity worldwide in patients with liver disease, and liver transplantation. Raised ferritin levels play an important role of intervening the process which is associated with hepatic injury. Screening with non-invasive strategies can detect the disease at early stage and intervention could be initiated. To determine correlation between serum ferritin levels and liver stiffness values in patients of chronic hepatitis C. Methods: A cross-sectional study was conducted at 103 Cam Khe Clinic from May 2019 to April 2020. 93 patients with chronic hepatitis C fulfilling inclusion criteria were included in this study. Liver fibrosis stages was appreciated using transient hepatic elastography by Fibroscan, the activities of serum liver function biomarker enzymes and serum ferritin levels were determined by automated analyser. Results: The average age of patients was 48 years, with men accounted for 78% of the total. The mean serum ferritin value was 148.19 ng/ml, liver stiffness measurements range from 12.5 to 75.5 kPa, with a median value of 17.39 ± 15.98 kPa. Significantly elevated levels of serum ferritin (P<0.001), were detected in patients with severe fibrosis compared to mild fibrosis. Concentration of serum ferritin was increased with the evolution of fibrosis in all stages from F0 to F4 and this increase was significant (P<0.01) in cirrhotic patients (F4). There was a positive correlation between serum level of ferritin and progression of fibrosis (0.979391) (r = 0.976). Conclusions: There is significant correlation between serum ferritin and liver stiffness. Serum ferritin concentration may be used as liver fibrosis biomarkers.
Thai Thanh Hoang Thi,Binh D.T. Trinh,Phuong Le Thi,Dieu Linh Tran,박기동,Dai Hai Nguyen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Because of the toxic glutaraldehyde, the chitosan-glutaraldehyde hydrogels are seriously limited inbiomedical applications. In this study, exploiting bioactive compounds of Aloe barbadensis Miller, the chitosan/Aloe barbadensis Miller-glutaraldehyde (CS/AV-GDA) hydrogels were fabricated with 4-fold lowerglutaraldehyde concentration without compromising hydrogel characteristics. The gelation time wascontrolled from a few seconds to several hours. The elastic modulus was varied from 483 to 99940 Pa. The CS/AV-GDA hydrogels could release the natural nitrite amount from 24.0 to 89.6 lM within the firsthour for antibacterial activity, then continuously deliver a few lM every next hour for cell activities. Theantibacterial test against Escherichia coli and Staphylococcus aureus revealed that the CS/AV-GDA hydrogelscould kill the planktonic bacteria 5-fold more highly than control and prevent bacteria attachmenton hydrogel surface effectively. Although the CS/AV-GDA hydrogels consumed only 0.25% glutaraldehydeconcentration, their antibacterial capacities were comparable to chitosan-only hydrogels with 2% glutaraldehyde. For cytotoxicity tests, the CS/AV-GDA hydrogels using 0.25% glutaraldehyde concentrationinduce the human dermal fibroblasts proliferation significantly. All CS/AV-GDA hydrogels with glutaraldehydecrosslinker less than 1% showed non-cytotoxicity. As a result, the new CS/AV-GDA hydrogelsmight become an attractive candidate for medicine regeneration and tissue engineering.
Novel antibiotic delivery using graphene oxide immobilized surfaces
( Tran Dieu Linh ),( Thai Thanh Hoang Thi ),( Phuong Le Thi ),박기동 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Implant-related infection is a noteworthy issue because of their negative effect to the success of implantation, and the cost of treatment. To solve this problem, the development of antimicrobial surface has been considered as an urgent mission. Herein, we demonstrated that graphene oxide (GO)-immobilized TiO<sub>2</sub> surface is an efficient carrier for the local delivery of antibiotic. The phenol-functionalized GO deriva-tive was synthesized and immobilized on TiO<sub>2</sub> under the catalysis of tyrosinase, following by the loading of doxycycline hyclate (Dox). The modified surface was able to carry 36 μg of Dox and ensured the release for a month. These surfaces also showed good antibacterial activity against both E. coli and S. aureus, without the cytotoxic effect on hDFBs. It is expected that the release of Dox from GO-immobilized surfaces can solve the pressing need for enhanced infection control
( Tran Dieu Linh ),( Thai Thanh Hoang Thi ),( Phuong Le Thi ),류승배,박기동 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Nowadays, to overcome the implant-related infection issue, many researches have been done to develop the antimicrobial surfaces, including the immobilization of antibacterial agents. Herein, graphene oxide (GO), a popular antibacterial agent with long-term and excellent activity, was immobilized on titanium dioxide (TiO<sub>2</sub>) substrates via tyrosinase-catalyzed reaction. GO was oxidized from graphene, following by the conjugation of the phenol groups using EDC/NHS chemistry, making GO capable to be oxidized by tyrosinase. These phenol moieties were oxidized into o-quinones by tyrosinase, can easily attach to TiO<sub>2</sub>. The GO immobilized surface show the antibacterial effect against both E.coli and S.aureus. Besides, they also show the biocompatibility with human dermal fibroblasts (hDFBs). This study presents a facile and rapid approach for enhancing antibacterial activity of TiO<sub>2</sub>.
Minh-Huy Dinh Dang,Linh Ho Thuy Nguyen,Trang Thi Thu Nguyen,Ngoc Xuan Dat Mai,Phuong Hoang Tran,Tan Le Hoang Doan 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Functionalized metal–organic frameworks have recently received significant attention in heterogeneouscatalysis applications due to their high catalytic activity. In this work, a sulfate-functionalized Hf-clusterbasedmetal–organic framework was prepared via sulfation of a Hf-MOF, named Hf-BTC, constructed byHf6 clusters and 1,3,5-tricarboxylate linkers. The Hf-BTC-SO4 material was consequently demonstrated tobe an efficiently reusable superacid catalyst for a one-pot three-component reaction of pyrimido[1,2-a]benzimidazoles synthesis. The reaction catalyzed by the sulfated Hf-BTC could be carried out under mildand solvent-free conditions and give superior performance in a wide range of substrates. According todetailed investigation, the good catalytic performance of the sulfated-functionalized MOF likely originatesfrom the high-porosity framework and the high active sites of the functionalized clusters. Importantly, the catalyst could be easy to recover and reuse the functionalized framework several timeswith minor changes in catalytic efficiency.
Vingroup: The Rising Dragon That Put Vietnam on the Global Map
Giap Vu Nam Duong,Hoang Khanh Linh,정경화,Nguyen Khanh Linh,Nguyen Phuong Hoa,Phan Hai Dang,Thai Thi Phuong Nga Academy of Asian Business (AAB) 2022 Academy of Asian Business Review Vol.8 No.1
Vingroup JSC (formerly Technocom) was founded in Ukraine in 1993 as an instant noodle factory. Since then, the Group has expanded into many other industries, placing tourism and hospitality as their first stepping-stone, then venturing into retail, real estate, education, and recently shifting towards a promising industrial and technology industry. Vingroup has now become the largest conglomerate in Vietnam in terms of market capitalization (VnExpress International, 2019). Having established a solid foundation in the Vietnamese market, Vingroup is eyeing the new promising yet challenging international market, with its competitive advantage in industrials and technology. Standing at a crucial juncture in its ascent, the conglomerate must implement a comprehensive and long-term strategy to reach its next milestone. In 2016, Vingroup primarily focused on four main business segments, encompassing property, hospitality - entertainment, consumer retail, and social infrastructure services. Over the course of two decades, Vinpearl and Vincom have grown into the market-leading hospitality and shopping malls brand in Vietnam. The brands’ establishment coincided with the flourishing economy of the country in the early 2000s, therefore, quickly achieved market dominance. Having such favorable conditions, the Group continued its expansion and investment in other backboned industries, which has reaped correspondingly fruitful results. The key success factors of Vingroup lies in an entrepreneurial mindset, speed, perfectionism and discipline, and last but not least, the national spirit. These traits have allowed the Group to unleash its potential capabilities and go beyond all boundaries. Both small-and-medium-sized companies and big firms can take Vingroup as a lesson for their strategy and corporate culture so that they can lead successful and sustainable growth in today’s competitive market.
Minh-Huy Dinh Dang,Trang Thi Thu Nguyen,Bao Quang Gia Le,Linh Ho Thuy Nguyen,Ngoc Xuan Dat Mai,My Van Nguyen,Phuong Hoang Tran,Tan Le Hoang Doan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
Pd-incorporated Zr-based metal–organic framework containing sulfone groups, named Pd(II)BUT-11, wassuccessfully prepared by dispersing the sulfone-functionalized MOF in Pd(OAc)2 solution. X-ray diffraction,scanning electron microscopy, N2 isotherm sorption, X-ray photoelectron spectroscopy, and thermogravimetricanalysis were applied to determine the features of the Pd-incorporated MOF. In the catalyticstudies, Pd(II)@BUT-11 was shown to be an efficient heterogeneous catalyst for synthesizing various stilbenederivatives via the cross-coupling Heck reaction with DABCO-derived deep eutectic solvent (DES) asa green solvent. Notably, the catalyst and the solvent could be recovered and reused, with their activityand structure remaining stable throughout several trials. The method provides an alternative solution tothe conventional catalysts and solvents, resulting in a green and efficient stilbene synthesis process. Furthermore, the stilbenes were separated by extraction with ethyl acetate due to the low solubility ofDES with this solvent.