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- 저자 : Lingfeng Liu (검색결과 4 건)
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Macrophage Migration Inhibitory Factor (MIF) Interacts with Bim and Inhibits Bim-mediated Apoptosis
Lingfeng Liu,Jinzhong Chen,Chaoneng Ji,Jiayi Zhang,Junlei Sun,Yao Li,Yi Xie,Shaohua Gu,Yumin Mao 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.2
The pro-apoptotic Bcl-2 family member Bim acts as a sensor for apoptotic stimuli and initiates apoptosis through the mitochondrial pathway. To identify novel regulators of Bim, we employed the yeast two-hybrid system and isolated the human gene encoding macrophage migration inhibitory factor (MIF), a ubiquitously expressed proinflammatory mediator that has also been implicated in cell proliferation, the cell cycle and carcinogenesis. The interaction between MIF and Bim was confirmed by both in vitro and in vivo protein interaction assays. Intriguingly, protein complexes between MIF and the three major Bim isoforms (BimEL/BimL/BimS) could be detected in HEK293 and K562 cells, especially in cells undergoing apoptosis. Moreover, exogenous expression of MIF partially inhibited Bim-induced apoptosis in HEK293 cells. SiRNA-mediated knockdown of MIF increased apoptosis in K562 cells exposed to the chemical oxidant diamide. Endogenous MIF may regulate the pro-apoptotic activity of Bim and inhibit the release of cytochrome c from mitochondria.
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Analysis on the safe distance between shield tunnel through sand stratum and underlying karst cave
Wei Wan,Shiming Gao,Lingfeng Liu,Wushuang Wen,Ping Li,Jianping Chen 한국자원공학회 2019 Geosystem engineering Vol.22 No.2
When a subway tunnel passes through a karst geological area, in order to ensure the stability of the tunnel, the safe distance between the tunnel and karst cave needs to be researched. This article is based on the construction project of Wuhan metro line 6 from Qianjincun station to Mayinglu station. In view of the geological condition of overlying sand and underlying limestone, by using numerical simulation and theoretical calculation and selecting a characteristic section, the influence law and degree of karst cave span, height-span ratio, and filling degree on the safe thickness of karst cave roof are studied and a forecasting model of the safe thickness of karst cave roof is established. Combined with dichotomy and numerical simulation, the critical horizontal safe distance beyond which cave collapse does not cause tunnel instability is calculated. The results show that: (1) the safe thickness of karst cave roof increases linearly with the increase of karst cave span, and decreases with the increase of height-span ratio and filling degree; (2) among the three factors, the effect of karst cave span is the most significant, the filling degree of karst cave is the second, and the influence of height-span ratio of karst cave is the weakest; (3) the proposed forecasting model passes the significance test, indicating that the model is very reasonable; and (4) the critical horizontal safe distance from the tunnel border to the karst cave boundary is 22.4 m. The research results can provide guidance for the design and construction of shield tunnels and karst cave treatment in karst areas.
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An investigation on the dynamics of domain switching of Bi0.5Na0.5TiO3-based ferroelectric ceramics
Zhipeng Gao,Hang Zhang,Yi Liu,Lingfeng Wu,Jia Yang,Tao Zhang,Haiyan Wang,Xuefeng Chen,Genshui Wang,Hongliang He 한국물리학회 2017 Current Applied Physics Vol.17 No.4
The dynamics of domain switching of Bi0.5Na0.5TiO3-based ferroelectric ceramic was investigated. With the electric field increasing, the domain switch experienced three sections of no domain switch region, creep region and flow region. In the creep region, the domain switch is dominated by the thermally activated domain wall movement. In flow region, the domain wall experience the viscous flow motion. For the BNT-BA-Zn ceramic, the activation energy of creep domain switch is much higher than it in flow region. With temperature increasing, the sensitivity of domain wall motion to the frequency is decreasing. This result demonstrated the domain switch of different ferroelectric materials could be quantitatively analyzed and compared based on the simple polarization - current - electric field data.
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Analytical Solution of Loosening Pressure Model for Shallow Tunnel Based on Pile-beam-arch Method
Tao Li,Zhongyu Zhang,Muchi Luo,Bo Liu,Yanlong Wang,Lingfeng Li 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8
Loosening of earth pressure by tunnels is an important parameter for the structural design of subway stations, this study analyzes the difference between the loosening pressures of each span of a shallow multi-span tunnel station using the pile-beam-arch (PBA) method. By conducting a similarity model test of the PBA method, we simulate the complete excavation process. We study the sliding failure mode of the overlying soil of the shallow-buried station and the law of change of the loosening pressure of each span. A simplified calculation model for the loosening pressure of shallow buried multi-span tunnels by the cavity pile method was developed, and the applicability of the formulae and sensitivity analysis of the parameters were carried out. The results reveal that the loosening pressure of the mid-span is transferred to the stress of the side-span during tunnel excavation. This finding contradicts Terzaghi’s and Bierbaumer’s methods, which do not consider the influence of tunnel structure on the loosening pressure of the overlying soil. The side span relaxation pressure is only related to the soil capacity and the depth of burial of the tunnel This research can provide an important theoretical reference for the design of the overburden load and lateral confining pressure of the PBA structure design.
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