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Yufeng Wang,Lihuan Mo,Kefu Chen,Jun Li,Jun Xu 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.2
A coagulation–flocculation process was used to treat papermaking-reconstituted tobacco slicewastewater with polyaluminium chloride (PAC) as coagulant and a cationic polyacrylamide (CPAM)as flocculant. To maximize the reduction of chemical oxygen demand (COD) and color, the jar tests werecarried out in the experiments and response surface methodology (RSM) was applied to optimize theprocess. A central composite design, i.e., a standard approach in RSM, was used to evaluate the effectsand interactions of three factors, i.e. PAC dosage, CPAM dosage and pH on the treatment efficiency. Results revealed that the maximum reduction of COD and color could be achieved at an optimalconditions, i.e., PAC = 715 mg/L, CPAM = 4.8 mg/L and pH = 6.6, from which the reduction of COD andcolor were 67.8% and 77.7%, respectively. The study also showed that the regression equations could beused as the theoretical basis for coagulation–flocculation process of papermaking-reconstituted tobaccoslice wastewater. They will be very helpful to flexibly select the appropriate process parameters in theengineering applications
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GTP Binding Is Required for SEPT12 to Form Filaments and to Interact with SEPT11
Xiangming Ding,Wenbo Yu,Ming Liu,ShuQing Shen,Fang Chen,Lihuan Cao,Bo Wan,Long Yu 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.3
Septins are a family of filament-forming GTP-binding proteins involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics. Here we report the biochemical and immunocytochemical characterization of a recently identified mammalian septin, SEPT12. SEPT12 binds GTP in vitro, and a mutation (Gly56 to Asn) in the GTPbinding motif abolished binding. Immunocytochemical analysis revealed that wild-type SEPT12 formed filamentous structures when transiently expressed in Hela cells whereas SEPT12G56A generated large aggregates. In addition, wild-type SEPT12 failed to form filaments when coexpressed with SEPT12G56A. We also observed that GTP-binding by SEPT12 is required for interaction with SEPT11 but not with itself.
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Penghui Cao,Junjie Tan,Xuezhen Liao,Jinwei Wang,Lihuan Chen,Ziyan Fang,Nannan Pan 대한소아청소년 정신의학회 2024 소아청소년정신의학 Vol.35 No.1
Objectives: This study aimed to explore the influence of depression severity, disease course, treatment status, and other factors on cognitive function in adolescents with depressive disorders. Methods: Participants who met the inclusion criteria were enrolled in the study. Sociodemographic data of each participant were recorded, including age, sex, and family history of mental disorders. Zung’s Self-Rating Depression Scale was used to assess depression status in adolescents. Moreover, P300 and mismatch negativity (MMN) were used to objectively evaluate the participants’ cognitive function. Results: Only 26.8% of the adolescents with depression received standard antidepressant treatment. The latencies of N2 (267.80±23.34 ms), P3 (357.71±32.09 ms), and MMN (212.10±15.61 ms) in the adolescent depression group were longer than those in the healthy control group (p<0.01). Further analysis revealed that the latency of MMN was extended with increased levels of depression in adolescents. The MMN latency was short in participants with depression receiving standardized treatment. Furthermore, the latency of MMN was positively correlated with the severity and duration of depression (correlation coefficients were 0.465 and 0.479, respectively) (p<0.01). Conclusion: Receiving standardized treatment and shortening the course of depression can reduce cognitive impairment in adolescents with depression.
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