Research on an Anchor Point Lever Beam Coupling Type Tuning Fork Micro-gyroscope

Lian-min Cao,Jian-wei Li,Xian-wen Liu,Feng-yao Sun 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6

This paper has designed an anchor point lever beam coupled tuning fork micro-gyroscope and tested its output performance. The tuning fork micro-gyro is designed to eliminate the output error caused by orthogonal coupling and in-phase-inverting coupling by structural decoupling and electrical decoupling, and can improve the anti-vibration performance and the modal optimization ability. It has derived the dynamic response working model of the non-ideal tuning fork micro-gyroscope, and optimized the structural parameters of the micro-gyroscope by simulation analysis. The microstructure processing has been realized by the SOI-MEMS process, sealed the processed structural prototype, and tested the performance through the established experimental system. According to the test results, the designed micro-gyroscope driving direction has greatly reduced the in-phase-inverting coupling through the anchor coupling lever beam, and the detection direction eff ectively suppressed the in-phase-inverting coupling through the stiff ness matching electrode. While closed-loop detecting, the measured Aallan variance zero-bias stability is 1.779°/h, and the 1σ zero-bias stability is 8.3°/h. While applying a stiff ness matching voltage, the measured vibration sensitivity is 23.9°/h/g.

Research on Output Characteristics of Double-Ended Fixed Beam Piezoelectric Energy Harvester Under Random Excitation

Lian-min Cao,Yong Cai,Guotai Xu,Jiulong Cui 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6

By use of the concept of impedance, this paper establishes a random energy harvester output model of double-ended fi xed beam piezoelectric energy harvester under random White Gaussian noise excitation, which is based on the discussion of the output characteristics infl uenced by changing vibration beam shape and piezoelectric sheet length under random excitation, while improving piezoelectric structure of double-ended fi xed beam piezoelectric energy harvester. It also deduces the output voltage, current and power of energy harvester with Fokker–Planck equation, which are verifi ed by Monte Carlo simulation and experimental testing. It can be found that improving vibration beam shape can reduce resonant frequency and increase average output power of the system. The optimal value of piezoelectric sheet length can be diff erent corresponding to diff erent structures, which proves that double-ended fi xed beam piezoelectric energy harvester under random White Gaussian noise excitation can achieve maximum output with optimal piezoelectric sheet length. In addition, in order to further improve the output performance of piezoelectric energy harvester under random excitation, it is necessary to increase the acceleration spectral density under random excitation and set an optimal value of the piezoelectric loading resistance, which is more suitable for energy harvester applied under random low-frequency environment.

Design and Test of the MEMS Coupled Piezoelectric- Electromagnetic Energy Harvester

Lian-min Cao,Zhi-xu Li,Cheng Guo,Peng-peng Li,Xiang-qiang Meng,Ting-ming Wang 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.4

This paper researches on the design and test of the output performance of double-end clamped MEMS coupled piezoelectric–electromagnetic energy harvester. It establishes the theoretical output model of the double-end clamped rectangular beam and trapezoidal beam piezoelectric–electromagnetic energy harvester, and optimizes the structure parameters of piezoelectric and electromagnetic unit with simulation analysis. It also respectively realizes the processing of piezoelectric and electromagnetic unit by MEMS and flexible PCB technology, and completes the performance test of structure prototype through the experimental system. The result showed that the capacity of MEMS coupled piezoelectric–electromagnetic energy harvester, which taked four coil piezoelectric with integrated electromagnetic in series, was 12.23 times higher than that of piezoelectric energy harvester. Also the output voltage and power of coupled trapezoidal beam energy harvester were respectively increased 18.89% and 2.26%, compared with coupled rectangular beam energy harvester.

Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer

Si-Qi Dong,Tong-Min Wang,Jiang-Bo Zhang,Yong-Qiao He,Wen-Qiong Xue,Zi-Yi Wu,Da-Wei Yang,Lian-Jing Cao,Jing-Wen Huang,Xi-Zhao Li,Pei-Fen Zhang,Xiao-Hui Zheng,Wei-Hua Jia 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role for 5-fluorouracil metabolism and has been associated with some side effects caused by capecitabine. The aim of our study is to identify the possible genetic predictors of capecitabine-induced HFS (CAP-HFS) in Chinese colorectal cancer patients.Materials and Methods Whole exons of TYMS were sequenced for 288 extreme phenotype HFS patients, including 144 severe or early-onset (first 2 cycles) moderate HFS extreme cases and 144 extreme controls with no reported HFS. The associations between polymorphisms and CAP-HFS were analyzed using logistic regression under an additive model.Results We identified a novel risk mutation (c.1A>G, chr18:657743), was associated with severe HFS in an extreme case who was affected during the first cycle of treatment. Moreover, we identified three new variants, rs3786362, rs699517, rs2790, and two previously reported variants, 5’VNTR 2R/3R and 3′-untranslated region 6-bp ins-del, which were significantly associated with CAP-HFS (p < 0.05). In silico analysis revealed that the effect of these polymorphisms in the TYMS region on the development of HFS might not be restricted solely to the regulation of TYMS expression, but also the TYMS catalytic activity through the indirect effect on ENOSF1 expression.Conclusion This study identified new polymorphisms in TYMS gene significantly associated with CAP-HFS, which may serve as useful genetic predictors for CAP-HFS and help to elucidate the underlying mechanism of HFS.

구강악안면재건을 위한 비골복합유리피판의 해부학적 고찰

김성민,조화련,서미현,명훈,이종호,Kim, Soung Min,Cao, Hua Lian,Seo, Mi Hyun,Myoung, Hoon,Lee, Jong Ho 대한악안면성형재건외과학회 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.6

The fibula is one of the most useful sources for harvest of a vascularized bone graft. The fibula is a straight, long, tubed bone, much stronger than any other available bone that can currently be used for a vascularized graft. It has a reliable peroneal vascular pedicle with a large diameter and moderate length. There is a definite nutrient artery that enters the medullary cavity, as well as multiple arcade vessels, which add to the supply of the bone through periosteal circulation. The vascularized fibula graft is used mainly for long segment defects of the long tubed bone of the upper and lower extremities. It can provide a long, straight length up to 25 cm in an adult. The fibula can be easily osteotomized and can be used in reconstruction of the curved mandible. Since the first description as a vascularized free fibula bone graft by Taylor in 1975 and as a mandibular reconstruction by Hidalgo in 1989, the fibula has continued to replace the bone and soft tissue reconstruction options in the field of maxillofacial reconstruction. For the better understanding of a fibular free flap, the constant anatomical findings must be learned and memorized by young doctors during the specialized training course for the Korean National Board of Oral and Maxillofacial Surgery. This article reviews the anatomical basis of a fibular free flap with Korean language.