1995-96년 한반도 남동부 지역의 미소지진 자료를 이용한 지각구조 모델의 비교 연구

이기화,정태웅,Lee, Gi Hwa,Jeong, Tae Ung 한국지구물리물리탐사학회 1999 지구물리 Vol.2 No.1

한국자원연구소 지진관측망의 1995-96년 미소지진 자료를 바탕으로 한반도 남동지역의 지각구조에 대하여, Lee (1979), 김상조·김소구(1983), 김성균·정부흥(1985)의 세 지각 모델 중 어느 것이 잔차의 최소자승을 만족하는지 검증하였다. 세 모델 잔차의 뚜렷한 차이가 관찰되지 않았으나, Lee 의 지각 모델이 약간 깊은 진원을 산출하는 경향이 있다. 한반도 지각의 층상구조는 아직 명백하지 않으므로 앞으로 더 많은 자연지진 자료 또는 인공지진 자료를 통해서 규명되어져야 한다. Using the microearthquake data acquired from 1995 to 1996 through the seismic network operated by the Korea Institute of Geology, Mining & Materials (KIGAM), the three P-wave velocity models proposed by Lee (1979), Kim·Kim (1983) and Kim·Jung (1985) concerning the structure of the southeastern part of the Korean peninsula were examined in terms of the least square errors of the P-wave arrival times. The three models do not differ significantly in arrival time residuals except that the Lee's model gives slightly deeper focuses than the others. The layering of the crust of the peninsula is not clear as yet and to be studied by more earthquake and explosion data in the future.

기구인영맥(氣口人迎脈)에 관한 연구

석진한,심철웅,최현배,이시형,Seok, Jin-Han,Sim, Cheol-Ung,Choi, Hyun-Bae,Lee, Si-Hyeong 대한한의정보학회 2012 大韓韓醫情報學會誌 Vol.18 No.1

Pulse diagnosis has been highly valued in many East Asian medical books, since "Huangdaineijing(黃帝內經)" published. Gigoo-inyoung pulse method(氣口人迎脈法) is one of the four pulse diagnostic methods originally written in"Huangdaineijing(黃帝內經)". At the late 3rd century, "Maijing(脈經)" redefined the positions of Gigoo-inyoung pulse(氣口人迎脈). According to "Maijing(脈經)", both spots were 1fen(分) in front of guan(關) but Gigoo on the right hand and Inyoung on the left hand. At the middle of 13th century, "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" had detailed view points about the manner of reading Gigoo-inyoung pulse. "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" explained clearly the position of 1fen(分) in front of guan(關) by sketch of wrist. The location indicated the border of cun(寸) and guan(關). It also explained clearly corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse by sketch. "Euihackipmoon(醫學入門)" is a comprehensive book on medicine written by Lee-Cheon(李?) in Ming(明) dynasty. In this book, pulse diagnosis is the most emphasized method among the four techniques of diagnosis(四診). Furthermore, it introduces detailed information about Gigoo-inyoung pulse method(氣口人迎脈法) in "Gigoo-inyoungmaekgyole(氣口人迎脈訣)". Lee-Cheon concured in the theory of "Yeongruegumbang(永類鈐方)" and "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and put a short essay about Gigoo-inyoung pulse named "Gigoo-inyoungmaekgyole(氣口人迎脈訣)" quoted from the two books. Therefore, throughout many chapters of "Euihackipmoon(醫學入門)", Gigoo-inyoung pulse is used in order to distinguish internal damage(內傷) and external contraction(外感). "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and "Euihackipmoon(醫學入門)" understood Gigoo-inyoung pulse commonly by corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse. Therefrom, Gigoo-inyoung pulse can distinguish seven emotions(七情) of internal damage(內傷) or six excesses(六淫) of external contraction(外感).

Anthraquinone계 화합물의 변이원성 및 유전독성 발현에 관한 연구(I) : Mutagenicity of emodin activated with cytochrome P-450 Cytochrome P-450에 의해 활성화된 emodin의 변이원성

李雄洙 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.2

It has been reported that several anthraquinone compounds possess mutagenicity and carcinogenicity. Emodin is one of the anthraquinone mycotoxins, and a constituent of several herb medicine used as laxative such as Rhei Rhizoma(rhubarb), Cassiae Semen(cassia seed) and Aloe. Emodin was selected as a model compound to solve a carcinogenic mechanism of the anthraquinone mycotoxins and to evaluate the safety of herb medicine. In this research, the mutagenicity and metabolic reaction of emodin were investigated with the purified cytochrome P-450s. In Ames test with the reconstituted cytochrome P-450 system derived from the hepatic microsomes of PB-induced rats, the mutagenicity of emodin activated with the fractionⅡ(P-448 type) was significantly higher than with the fraction Ⅰ(P-450 type). TLC analysis of the metabolites revealed that among 8 isozymes of P-450 type(Ⅰ-a, b, c, d) and P-448 type(Ⅱ-a, b, c, d), only ω-OH-emodin was detected on the TLC plate when emodin was incubated with 4 isozymes of P-450 type(Ⅰ-a, b, c, d). Whereas, 2-, 4-, 7-, ω-OH-emodin were detected in the metabolites produced by P-448 type(Ⅱ-a, b, c, d). Of 8 isozymes, Ⅱ-a possessed the highest activity in the production of 2-OH-emodin, a direct-acting mutagen. This Ⅱ-a was also represented to catalyze the hydroxylation of aflatoxin B1 and ochratoxin A into aflatoxin M1 and 4(R)-4-hydroxy-ochratoxin A, respectively. It was suggested that P-448 types play an important role in the metabolic activation of emodin.

여주 건조분말 함유식이가 고콜레스테롤 혈증 Rat의 혈청성분에 미치는 영향

이웅수 忠州大學校 2007 한국교통대학교 논문집 Vol.42 No.-

This research was carried out to investigate the hypocholesterolemic effects of diets containing bitter gourd(Momordica charantia, MC; Yeoju) powder in Sprague-Dawley male rats. After 2 weeks feeding with basal diet, 6 week old rats were fed with basal diet, diets containing 1% cholesterol, and 1% MC, 5% MC and 10% MC powder with 1% cholesterol for 2, 4 and 6 week. And then I measured the levels of glucose, triglyceride, total-, HDL-and LDL-cholesterol, and the activities of GOT, GPT in the serum of rats. The levels of triglyceride and total-cholesterol in the serum of rats were decreased remarkably in the groups fed with diet contained more 5% MC powder compared to the basal diet group for 2weeks. The levels of LDL-cholesterol were decreased in the all groups fed with diet contained MC power for 4weeks, especially groups fed with contained more 5% MC powder were more effective than the other groups, but the decrease of HDL-cholesterol level was not effective in all diet groups contained MC powder. The levels of blood sugar were decreased in all MC powder diet groups, and the decreased levels were more effective in the groups fed with diet contained more MC powder. The activities of GOT and GPT were also decreased in all MC powder diet groups. In conclusion, diets contained MC powder were effective in the decrease of triglyceride, total- and LDL-cholesterol, and glucose levels, and GOT and GPT activities in the serum of rats

Indoprofen 및 Indoprofen Lysinate와 Human Serum Albumin의 結合에 관한 硏究

李琬夏,柳柄泰,智雄吉,金東吉 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

Indoprofen, 4- (1, 3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzene acetic acid, has many advantages over the other antiinflammatory drugs, such as salicylates, naproxen. Although indoprofen is widely used as an antiinflammatory agent, it shows poor solubility in water. In order to inhance water solubility, indoprofen was made as lysine salt. The purpose of this study was to inspect the binding of the 1-anilinonaphthalene-8-sulfonatc(ANS) to human serum albumin (HSA) and to be to comparative studies on indoprofen lysinate and indoprofen in aspect of the binding to HSA and the number of binding sites was obtained using a fluorescent probe technique. The numbers of binding sites for indoprofen and indoprofen lysinate appear to be 3.35, 3.4, respectively and the association constants were found as follows; HSA-Indoprofen. ; K_b1 = 6.62 × 10 exp(5), K_b2 = 5.44 × 10 exp(4) HSA-Indoprofen lysinate ; K_b1 = 2.32 × 10 exp(5), K_b2 = 5.03 × 10 exp(4)

Fusarium 속 곰팡이가 생산하는 Mycotoxin인 Nivalenol의 발암성에 관한 연구

李雄洙 충주대 산업과학기술연구소 2000 産業科學論文集 Vol.8 No.-

Nivalenol(NIV), a trichothecene mycotoxin produced by Fusarium spp., was significantly contaminated to cereals such as barley, polished barley, wheat, malt and corn, and animal feeds at high level and high frequency throughout the world. Therefore, I was carried out this research to evaluate the toxicological effects especially carcinogenicity of NIV in mice during 2 years feeding trial. In 2 years feeding period, the survival rates were 52, 52, 48 and 69% in the groups given 0, 6, 12 and 30ppm NIV, respectively. Lethal case was not observed in the 30ppm group until 18 months feeding period. Mean survival days in each group for 2 years feeding period were 565, 629, 654 and 719 days. These results indicated the increase of life span in the NIV-treated groups. The incidence rates of total tumor after 2 years feeding trial were 50, 66, 59 and 56% in each groups, respectively. Most of tumors observed in control and NIV-treated groups were lymphomas which spontaneously occurred at high frequency. There was no significant difference in the tumor incidence rate between control and NIV-treated groups. The results of this research showed that NIV was not carcinogenic substance, and reversely increased life scan according to the concentration of NIV in mice.

Effect of Dietary Vitamin E on the Release of Iron and Generation of Mitochondrial Hydrogen Peroxide in Rat

이웅수 忠州大學校 2003 한국교통대학교 논문집 Vol.38 No.2

In this research, whether dietary vitamin E has a direct functional effect on the production of reactive oxygen species(ROS) in mitchondria, and whether dietary vitamin E influence the formation of free iron in rat tissues were determined. Additionally, if altered iron release is linked to the degree of peroxidative damage was determined. The results clearly showed that dietary vitamin E markedly reduced hydrogen peroxide production in the mitochondria of liver and skeletal muscle of both male and female rats in a dose-dependent manner. Also, the data showed that deprivation of vitamin E resulted in an increase of free iron in the skeletal muscle and spleen of male rats and liver, skeletal muscle, heart, kidney, and spleen of female rats. Supplementation with vitamin E significantly decreased the levels of free iron in the skeletal muscle of both male and female rats. Also, the levels of free iron were significantly inversely related to the concentration of supplemented vitamin E in the skeletal muscle, kidney, and spleen of male rats and liver, skeletal muscle, heart, kidney, and spleen of female rats. Deprivation of vitamin E caused a significant increase in the levels of thiobarbituric acid reactants(TBARS) in the liver, skeletal muscle, heart, kidney, and spleen of both male and female rats. Vitamin E does-dependently decreased TBARS in the liver and kidney of male rats and liver, skeletal muscle, and kidney of female rats. The results obtained from this research indicate that vitamin E regulates mitochondrial generation of ROS and attenuates the release of iron from its protein complexes. The results also suggest that the overprodution of mitochondrial ROS is the first event leading to tissue damage observed in vitamin E-deficiency syndromes and that formation of free iron is the first event of oxidative tissue damage.

전력 송·배전 시스템 상에서 발생하는 이벤트에 대한 데이터 마이닝 가상 트랜잭션과 연관 규칙의 적용

이준섭,이창언,윤상일,김응모 成均館大學校 科學技術硏究所 2002 論文集 Vol.53 No.1

There has been much research on data mining techniques for applying more advanced applications. In this paper, we introduce a approach to convert time series data into virtual transaction data for analysis power electronic transmission and distribution system. However, most of these techniques has focused on transaction data rather than time series data. We present a new way which is discovered and repaired faults of Electric Power system using Data Mining techniques.

Rat의 간세포 항산화계 및 지질 과산화에 미치는 Mycotoxins의 영향 : I. Effects of Fumonisin B₁, a Mycotoxin produced by Fusarium moniliforme I. Fumonisin B₁의 영향

李雄洙 忠州大學校 1994 한국교통대학교 논문집 Vol.29 No.2

The purpose of this study was to determine if fumonisin B₁(FB₁), a promoter for hepa tocarcinogenesis in rat, induces lipid peroxidation and alters the concentrations of antioxidant systems in rat liver cell. The hepatocytes were isolated from male Harlan Sprague-Dawley rat by using aseptic procedures, and treated with varying concentrations of FB₁(1μM,10μM and 50μM). The levels of malondialdehyde(MDA), conjugated diene(CD), vitamin A(V-A), vitamin E(V-E),γ-tocopheryl quinone(γ-TQ), vitaminC(V-C), glutathione(GSH), total lipids(TL), and protein were determined to assess oxidative damage and antioxidant status on the hepatic cell. FB₁ increased the levels of MDA and CD, oxidative products of cellular lipid. And FB₁ decreased the levels of cellular antioxdants such as V-E, and V-A, and V-C, but increased GSH level. This study shows that the adiministration of FB₁, a mycotoxin produced by Fusarium moniliforme, did increase indices of lipid peroxidation, but that cellular antioxidant defences were inhibited by FB₁.

集團給食所 및 家庭의 廚房에서 使用하는 행주의 衛生學的 處理에 관한 硏究

李雄洙,崔錫南 충주대 2003 産業科學論文集 Vol.11 No.-

This study was carried out to find out the method on hygienic treatment of dishcloth used at the cookroom of mass meal service center and household in order to prevent food poisoning and oral infectious disease. This research was examined with three methods(washing, boiling and chlorine solution treatment) based on materials for the questionnaire by 28 persons who engaged in mass meal service center and telephone interview by 100 housewives. The indicator bacteria on the fecal contamination in food hygiene such as Escherichia coli, Staphylococcus aureus, Brochothrix thermosphacta, Salmonella typhimurium, vibrio parahae-molyticus and pseudomonas aeruginosa, and Shigella sonnei, one of oral epidemic bacteria, were used in this study. The results of this study related to food hygienic and micro-biological tests were the following : 1) By washing treatment, the indicator bacteria and Shigella sonnei were detected less 1/2 to 1/4 than initial viable cell counts. 2) After boiling treatment for 10min, E. coli, Pseudo. aeruginosa and Brocho. thermo-sphacta were found 63-340 CFU/㎖, and Staphy. aureus and Sal. typhimurium were detected 1-2CFU/℃, but Vibrio parahaemolyticus and Shigella sonnei not detected. 3) After boiling treatment for 20min, E. coli, Brocho. thermosphacta and Pseudo. aeru-ginosa were detected 4-130CFU/℃, but Staphy. aureus, Sal. typhimurium, Vibrio par-ahaemolyticus and Shigella sonnei died out completely. 4) After boiling treatment for 30min, only Pseudo. aeruginosa was found, and the other bacteria were not detected. 5) In case of soaking treatment in chlorine solution, all tested bacteria were detected to 1-2500 CFU/℃ in 80ppm solution. In 160ppm chlorine solution, Brocho. thermosphacta, Sal. typhimurium, Vibrio parahaemolyticus, Pseudo. aeruginosa and Shigella sonnei were existed to 2-32CFU/℃, but E. coli and Staphy. aureus were died out. In 320ppm chlorine solution, only Pseudo. aeruginosa was found to 13CFU/℃, and the other bacteria were not detected. In 640ppm chlorine solution, all tested bacteria were not detected. In conclusion, this study suggested that boiling over 30min and soaking in 640ppm chlorine solution are very good methods as the hygienic treatment of dishcloth contaminated with food poisoning and oral infectious disease bacteria.