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Lee, Han-Byoel,Kang, Un-Beom,Moon, Hyeong-Gon,Lee, Jiwoo,Lee, Kyung-Min,Yi, Minju,Park, Yong Sun,Lee, Jong Won,Yu, Jong-Han,Choi, Seung Ho,Cho, Sang Heon,Lee, Cheolju,Han, Wonshik,Noh, Dong-Young Potamitis Press 2015 Anticancer research Vol.35 No.11
<P>We aimed to develop a plasma protein signature for breast cancer diagnosis by using multiple reaction monitoring (MRM)-based mass spectrometry.</P>
Young Mi Yoon, Hyung-Suk Lee, Shin-Hye Baek, Hye Lim Lee, Minju Yeo, Seo Young Choi, Ji Seon Kim, Sung-Hyun Lee, Sang-Soo Lee, Dong-Ick Shin 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.2
Background and Purpose: The Ankle-Brachial Index (ABI) is the ratio of blood pressure in the lower legs to that in the arms. The intima-media thickness (IMT) of extracranial carotid arteries determined by B-mode ultrasound is a measurable index of the presence of atherosclerosis. A low ABI and a high carotid IMT are independently related to increased risk of cardiovascular events. This study examined the association between carotid IMT and ABI in patients with ischemic stroke. Materials and Methods: Retrospectively, 116 hospitalized patients with ischemic stroke were recruited. Using a pulse wave velocity ABI device along with carotid duplex sonography, we measured carotid IMT and ABI and investigated the correlation between average values. Results: There was a significant difference in carotid IMT between the normal and abnormal ABI groups (P=0.0262). The group with an abnormal ABI was more than five times as likely to have increased carotid IMT as the group with a normal ABI (age, sex-adjusted OR 5.67 (95% CI 1.85~17.38)). The ABI and carotid IMT showed a weak inverse linear correlation in patients with ischemic stroke (correlation coefficient −0.378 after adjusting for age and sex). Conclusion: Our study suggests that an abnormal ABI is associated with a high carotid IMT in patients with ischemic stroke.
Lee, Yunho,Gerrity, Daniel,Lee, Minju,Bogeat, Angel Encinas,Salhi, Elisabeth,Gamage, Sujanie,Trenholm, Rebecca A.,Wert, Eric C.,Snyder, Shane A.,von Gunten, Urs American Chemical Society 2013 Environmental science & technology Vol.47 No.11
<P>Ozonation is effective in improving the quality of municipal wastewater effluents by eliminating organic micropollutants. Nevertheless, ozone process design is still limited by (i) the large number of structurally diverse micropollutants and (ii) the varying quality of wastewater matrices (especially dissolved organic matter). These issues were addressed by grouping 16 micropollutants according to their ozone and hydroxyl radical (<SUP>•</SUP>OH) rate constants and normalizing the applied ozone dose to the dissolved organic carbon concentration (i.e., g O<SUB>3</SUB>/g DOC). Consistent elimination of micropollutants was observed in 10 secondary municipal wastewater effluents spiked with 16 micropollutants (∼2 μg/L) in the absence of ozone demand exerted by nitrite. The elimination of ozone-refractory micropollutants was well predicted by measuring the <SUP>•</SUP>OH exposure by the decrease of the probe compound <I>p</I>-chlorobenzoic acid. The average molar <SUP>•</SUP>OH yields (moles of <SUP>•</SUP>OH produced per mole of ozone consumed) were 21 ± 3% for g O<SUB>3</SUB>/g DOC = 1.0, and the average rate constant for the reaction of <SUP>•</SUP>OH with effluent organic matter was (2.1 ± 0.6) × 10<SUP>4</SUP> (mg C/L)<SUP>−1</SUP> s<SUP>–1</SUP>. On the basis of these results, a DOC-normalized ozone dose, together with the rate constants for the reaction of the selected micropollutants with ozone and <SUP>•</SUP>OH, and the measurement of the <SUP>•</SUP>OH exposure are proposed as key parameters for the prediction of the elimination efficiency of micropollutants during ozonation of municipal wastewater effluents with varying water quality.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2013/esthag.2013.47.issue-11/es400781r/production/images/medium/es-2013-00781r_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es400781r'>ACS Electronic Supporting Info</A></P>
Lee, Haeun,Song, Woon Young,Kim, Minju,Lee, Min Wook,Kim, Soojeung,Park, Ye Song,Kwak, Kyungwon,Oh, Man Hwan,Kim, Hak Joong American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.20
<P>Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for <I>Acinetobacter baumannii</I>. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against <I>A. baumannii</I>.</P> [FIG OMISSION]</BR>
Lee, Minju,Jung, Je Won,Kim, Daesan,Ahn, Young-Joon,Hong, Seunghun,Kwon, Hyung Wook American Chemical Society 2015 ACS NANO Vol.9 No.12
<P>We report a floating electrode-based bioelectronic tongue mimicking insect taste systems for the detection and discrimination of umami substances. Here, carbon nanotube field-effect transistors with floating electrodes were hybridized with nanovesicles containing honeybee umami taste receptor, gustatory receptor 10 of <I>Apis mellifera</I> (AmGr10). This strategy enables us to discriminate between <SMALL>l</SMALL>-monosodium glutamate (MSG), best-known umami tastant, and non-umami substances with a high sensitivity and selectivity. It could also be utilized for the detection of MSG in liquid food such as chicken stock. Moreover, we demonstrated the synergism between MSG and disodium 5′-inosinate (IMP) for the umami taste using this platform. This floating electrode-based bioelectronic tongue mimicking insect taste systems can be a powerful platform for various applications such as food screening, and it also can provide valuable insights on insect taste systems.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-12/acsnano.5b03031/production/images/medium/nn-2015-03031z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b03031'>ACS Electronic Supporting Info</A></P>