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Lee, Ji-Young,Kim, Bong Jo,Sim, Gyujin,Kim, Gyu-Tae,Kang, Dawon,Jung, Jae Hun,Hwa, Jeong Seok,Kwak, Yeon Ju,Choi, Yeon Jin,Park, Young Sook,Han, Jaehee,Lee, Cheol Soon,Kang, Kee Ryeon The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.6
<P>The influence of spinal cord injury (SCI) on protein expression in the rat urinary bladder was assessed by proteomic analysis at different time intervals post-injury. After contusion SCI between T9 and T10, bladder tissues were processed by 2-DE and MALDI-TOF/MS at 6 hr to 28 days after SCI to identify proteins involved in the healing process of SCI-induced neurogenic bladder. Approximately 1,000 spots from the bladder of SCI and sham groups were visualized and identified. At one day after SCI, the expression levels of three protein were increased, and seven spots were down-regulated, including heat shock protein 27 (Hsp27) and heat shock protein 20 (Hsp20). Fifteen spots such as S100-A11 were differentially expressed seven days post-injury, and seven proteins including transgelin had altered expression patterns 28 days after injury. Of the proteins with altered expression levels, transgelin, S100-A11, Hsp27 and Hsp20 were continuously and variably expressed throughout the entire post-SCI recovery of the bladder. The identified proteins at each time point belong to eight functional categories. The altered expression patterns identified by 2-DE of transgelin and S100-A11 were verified by Western blot. Transgelin and protein S100-A11 may be candidates for protein biomarkers in the bladder healing process after SCI.</P>
2 스풀 혼합흐름 배기방식 터보팬 엔진 성능해석 모델링
이승헌(Seungheon Lee),이형진(Hyoung Jin Lee),김상조(Sangjo Kim),나규진(Gyujin Na),김중회(Jung Hoe Kim) 한국추진공학회 2023 한국추진공학회지 Vol.27 No.1
n this study, performance analysis modeling of two spool mixed flow type turbofan engine according to steady-state and transient is performed. The target engine is selected as F100-PW-229 from Pratt & Whitney, and main engine components including fan, high pressure compressors, combustion, high pressure turbines, low pressure turbines, mixer, convergent-divergent nozzle are modeled. The cooling effect of turbine through secondary flow path are considered in engine simulation model. We develop in-house Matlab/Simulink-based engine performance analysis program capable of analyzing internal engine state and compare it with GASTURB which is generally used as a commercial engine analysis program.