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FIXED POINTS AND HOMOTOPY RESULTS FOR ĆIRIĆ-TYPE MULTIVALUED OPERATORS ON A SET WITH TWO METRICS
Lazar, Tania,O'Regan, Donal,Petrusel, Adrian Korean Mathematical Society 2008 대한수학회보 Vol.45 No.1
The purpose of this paper is to present some fixed point results for nonself multivalued operators on a set with two metrics. In addition, a homotopy result for multivalued operators on a set with two metrics is given. The data dependence and the well-posedness of the fixed point problem are also discussed.
New Adaptive Compandor for LTE Signal Compression Based on Spline Approximations
Lazar Zoran Velimirovic,Svetislav Maric 한국전자통신연구원 2016 ETRI Journal Vol.38 No.3
With the constant increase in network traffic, wireless operators are finding it more challenging to keep network hardware costs to a minimum. At the same time, the energy cost associated with operating a network has increased proportionally. Therefore, the search for higher network capacity is simultaneously accompanied by the search for a cost-efficient network deployment. In this paper, we show that a saving in transmitted signal energy can be achieved at the signal design level by deploying very specific signal processing techniques. Using an orthogonal frequency-division multiplexing signal for Long-Term Evolution networks as an example, we utilize a novel non-uniform companding quantizer to save a transmitted signal energy. Our results show that by using non-uniform quantization it is possible to further optimize 4G wireless networks.
Lazar, Prettina,Lee, Yun-O,Kim, Song-Mi,Chandrasekaran, Meganathan,Lee, Keun-Woo Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.6
The behavior of peptide or protein solutes in saline aqueous solution is a fundamental topic in physical chemistry. Addition of ions can strongly alter the thermodynamic and physical properties of peptide molecules in solution. In order to study the effects of added ionic salts on protein conformation and dynamics, we have used the molecular dynamics (MD) simulations to investigate the behavior of Staphylococcus aureus Hfq protein under two different ionic concentrations: 0.1 M NaCl and 1.0 M NaCl in presence and absence of RNA (a hepta-oligoribonucleotide AU5G). Hfq, a global regulator of gene expression is highly conserved and abundant RNA-binding protein. It is already reported that in vivo the increase of ionic strength results in a drastic reduction of Hfq affinity for $Q{\beta}$ RNA and reduces the tendency of aggregation of Escherichia coli host factor hexamers. Our results revealed the crucial role of 0.1 M NaCl Hfq system on the bases with strong hydrogen bonding interactions and by stabilizing the aromatic stacking of Tyr42 residue of the adjacent subunits/monomers with the adenine and uridine nucleobases. An increase in RNA pore diameter and weakened compactness of the Hfq-RNA complex was clearly observed in 1.0 M NaCl Hfq system with bound RNA. Aggregation of monomers in Hfq and the interaction of Hfq with RNA are greatly affected due to the presence of high ionic strength. Higher the ionic concentration, weaker is the aggregation and interaction. Our results were compatible with the experimental data and this is the first theoretical report for the experimental study done in 1980 by Uhlenbeck group for the present system.
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Lazar, Jozsef,Braun, Derek C,Tó,th, Attila,Wang, Yun,Pearce, Larry V,Pavlyukovets, Vladimir A,Blumberg, Peter M,Garfield, Susan H,Wincovitch, Stephen,Choi, Hyun-Kyung,Lee, Jeewoo American Society for Pharmacology and Experimental 2006 Molecular pharmacology Vol.69 No.4
<P>Evidence that the ligand binding site of TRPV1 lies on the inner face of the plasma membrane and that much of the TRPV1 itself is localized to internal membranes suggests that the rate of ligand entry into the cell may be an important determinant of the kinetics of ligand action. In this study, we synthesized a BODIPY TR-labeled fluorescent capsaicin analog (CHK-884) so that we could directly measure ligand entry. We report that CHK-884 penetrated only slowly into Chinese hamster ovary (CHO) cells expressing rat TRPV1, with a t1/2 of 30 +/- 4 min, and localized in the endoplasmic reticulum and Golgi. Although CHK-884 was only weakly potent for TRPV1 binding (Ki = 6400 +/- 230 nM), it was appreciably more potent when assayed by intracellular calcium imaging and was 3.2-fold more potent with a 1-h incubation time (37 nM) than with a 5-min incubation time. Olvanil, a highly lipophilic vanilloid, yielded an EC50 of 4.3 nM upon intracellular calcium imaging with an incubation time of 1 h, compared with an EC50 value of 29.5 nM for calcium imaging assayed at 5 min. Likewise, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2 pM if incubated with CHO-TRPV1 cells for 2 h before addition of capsaicin compared with 1.5 nM if added simultaneously. We conclude that some vanilloids may have slow kinetics of uptake; this slow uptake may affect assessment of structure activity relations and may represent a significant factor for vanilloid drug design.</P>
Prettina Lazar,이윤호,Songmi Kim,Meganathan Chandrasekaran,이근우 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.6
The behavior of peptide or protein solutes in saline aqueous solution is a fundamental topic in physical chemistry. Addition of ions can strongly alter the thermodynamic and physical properties of peptide molecules in solution. In order to study the effects of added ionic salts on protein conformation and dynamics, we have used the molecular dynamics (MD) simulations to investigate the behavior of Staphylococcus aureus Hfq protein under two different ionic concentrations: 0.1 M NaCl and 1.0 M NaCl in presence and absence of RNA (a hepta-oligoribonucleotide AU5G). Hfq, a global regulator of gene expression is highly conserved and abundant RNA-binding protein. It is already reported that in vivo the increase of ionic strength results in a drastic reduction of Hfq affinity for Qβ RNA and reduces the tendency of aggregation of Escherichia coli host factor hexamers. Our results revealed the crucial role of 0.1 M NaCl Hfq system on the bases with strong hydrogen bonding interactions and by stabilizing the aromatic stacking of Tyr42 residue of the adjacent subunits/monomers with the adenine and uridine nucleobases. An increase in RNA pore diameter and weakened compactness of the Hfq-RNA complex was clearly observed in 1.0 M NaCl Hfq system with bound RNA. Aggregation of monomers in Hfq and the interaction of Hfq with RNA are greatly affected due to the presence of high ionic strength. Higher the ionic concentration, weaker is the aggregation and interaction. Our results were compatible with the experimental data and this is the first theoretical report for the experimental study done in 1980 by Uhlenbeck group for the present system.
Eversion Carotid Endarterectomy : A Short Review
Davidovic, Lazar B.,Tomic, Ivan Z. The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.3
Carotid endarterectomy (CEA) is the main procedure in carotid surgery, as well as the most frequent vascular procedure. Two techniques of CEA are available : eversion and conventional plus patch angioplasty. Eversion CEA is anatomic procedure that reduces ischemic and total operative time. Simultaneous correction of the joined carotid kinking and coiling is possible, easy and safe, while the usage of patch is excluded. Thanks to oblique shape of anastomosis, eversion CEA is associated with low risk of long-term restenosis. The false anastomotic aneurysms occurrence is very rare, almost impossible after eversion CEA. However, the usage of carotid shunt during eversion CEA is not always simple, while proximal or distal extension of the carotid plaque can make eversion CEA more difficult and risky. Eversion CEA should be the first choice in carotid surgery. Conventional CEA is indicated in cases when carotid plaque is extended more than usual, as well as, if the usage of carotid shunt is necessary.