An Interview with Lynne Pearce

Lynne Pearce ; Jinhyoung Lee Academy of Mobility Humanities 2023 Mobility Humanities Vol.2 No.2

Lynne Pearce is Professor of Literary and Cultural Theory in the Department of English Literature and Creative Writing at Lancaster University, UK. She is also Co-Director (Humanities) of the University’s Centre for Mobilities Research (CeMoRe) and has been involved in the Centre as an Associate Director since 2015. With Peter Merriman (Aberystwyth University, UK), she has played a leading role in developing the field of Mobility Humanities following a landmark colloquium hosted by CeMoRe in 2014 (see special issue of Mobilities12.4). While her early publications were in the field of feminist theory and reader theory (e.g., Woman/Image/Text (1991); Reading Dialogics(1994); Feminism and the Politics of Reading (1997); Romance Writing (2007)), since 2010 her research has focused on mobilities (see Drivetime (2016) and Mobility, Memory and the Lifecourse (2019)). She is also co-editor of the book series Palgrave Studies in Mobilities, Literature and Culture.

Yang–Baxter solution of dimers as a free-fermion six-vertex model

Pearce, Paul A,Vittorini-Orgeas, Alessandra IOP 2017 JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL Vol.50 No.43

<P>It is shown that Dimers is Yang–Baxter integrable as a six-vertex model at the free-fermion point with crossing parameter <img ALIGN='MIDDLE' ALT='$ \newcommand{\la}{\lambda} \lambda=\frac{\pi}{2}$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn001.gif'/>. A one-to-many mapping of vertices onto dimer configurations allows the free-fermion solutions to be applied to the anisotropic dimer model on a square lattice where the dimers are rotated by <img ALIGN='MIDDLE' ALT='$45^{\circ}$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn002.gif'/> compared to their usual orientation. This dimer model is exactly solvable in geometries of arbitrary finite size. In this paper, we establish and solve inversion identities for Dimers with periodic boundary conditions on the cylinder. In the particle representation, the local face tile operators give a representation of the fermion algebra, and the fermion particle trajectories play the role of nonlocal (logarithmic) degrees of freedom. In a suitable gauge, the dimer model is described by the Temperley–Lieb algebra with loop fugacity <img ALIGN='MIDDLE' ALT='$ \newcommand{\la}{\lambda} \beta=2\cos\lambda=0$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn003.gif'/>. At the isotropic point, the exact solution allows for the explicit counting of <img ALIGN='MIDDLE' ALT='$45^{\circ}$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn004.gif'/> rotated dimer configurations on a periodic <img ALIGN='MIDDLE' ALT='$M\times N$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn005.gif'/> rectangular lattice. We show that the modular invariant partition function on the torus is the same as that of symplectic fermions and critical dense polymers. We also show that nontrivial Jordan cells appear for the dimer Hamiltonian on the strip with vacuum boundary conditions. We therefore argue that, in the continuum scaling limit, the dimer model gives rise to a <I>logarithmic</I> conformal field theory with central charge <img ALIGN='MIDDLE' ALT='$c=-2$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn006.gif'/>, minimal conformal weight <img ALIGN='MIDDLE' ALT='$ \newcommand{\D}{\Delta} \Delta_{{\rm min}}=-1/8$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn007.gif'/> and effective central charge <img ALIGN='MIDDLE' ALT='$c_{{\rm eff}}=1$ ' SRC='http://ej.iop.org/images/1751-8121/50/43/434001/aaa86bcieqn008.gif'/>.</P>

Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1)

Pearce, Larry V.,Ann, Jihyae,Jung, Aeran,Thorat, Shivaji A.,Herold, Brienna K. A.,Habtemichael, Amelework D.,Blumberg, Peter M.,Lee, Jeewoo American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.19

<P>Transient receptor potential vanilloid 1 (TRPV1) has emerged as a promising therapeutic target. While radiolabeled resiniferatoxin (RTX) has provided a powerful tool for characterization of vanilloid binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human TRPV1 than to the rodent TRPV1. We now describe a tritium radiolabeled synthetic vanilloid antagonist, 1-((2-(4-(methyl-[<SUP>3</SUP>H])piperidin-1-yl-4-[<SUP>3</SUP>H])-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(3-oxo-3,4-dihydro-2<I>H</I>-benzo[<I>b</I>][1,4]oxazin-8-yl)urea ([<SUP>3</SUP>H]MPOU), that embodies improved absolute affinity for human TRPV1 and improved synthetic accessibility.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2017/jmcmar.2017.60.issue-19/acs.jmedchem.7b00859/production/images/medium/jm-2017-008593_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm7b00859'>ACS Electronic Supporting Info</A></P>

IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

Pearce, Neil,Blair, Aaron,Vineis, Paolo,Ahrens, Wolfgang,Andersen, Aage,Anto, Josep M.,Armstrong, Bruce K.,Baccarelli, Andrea A.,Beland, Frederick A.,Berrington, Amy,Bertazzi, Pier Alberto,Birnbaum, L U.S. Dept. of Health, Education, and Welfare, Publ 2015 Environmental health perspectives Vol.123 No.6

<P>Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.</P><P>Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed.</P><P>Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed.</P><P>Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health.</P><P>Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, ‘t Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123:507–514; http://dx.doi.org/10.1289/ehp.1409149</P>

Building the Study of Tourism in the Asia Pacific Region

Pearce, Philip L. 한국호텔경영학회 ( 구 한국호텔외식경영학회 ) 1999 Korean Journal of Hotel Administration Vol.1 No.1

While the world of tourism itself is a glamorous, growing and exciting phenomenon, the world of the tourism researcher has suffered from two major difficulties in its own development. The first issue concerns the difficulty of building a cumulative body of knowledge, particularly in the Asia Pacific region where language and cultural differences as well as the state of tourism development produces very diverse tourism research endeavours. A record problem lies in the questionable objectivity of some tourism research. Some work, it can be argued, lacks the quality control mechanisms to guarantee its objectivity and soundness. In this paper these two difficulties are explained by reference to three cultures of tourism research; an academic culture, a government culture and a consultancy culture. It is argued that a range of individual and organisational solutions are available to hasten the growth of Asia Pacific tourism study. Suggested solutions include the building of the “invisible” college of scholars, the development of researchers with bi- or multi-cultural skills, partnerships between institutions at different levels of tourism study and the development of cooperative research centres. The value of the Asia Pacific Tourism Association in this web of solutions is highlighted.

A systematic investigation of the thermoelectric stability of Pt–Rh thermocouples between 1300 °C and 1500 °C

Pearce, J V,Edler, F,Elliott, C J,Greenen, A,Harris, P M,Izquierdo, C Garcia,Kim, Y-G,Martin, M J,Smith, I M,Tucker, D,Veltcheva, R I BUREAU INTERNATIONAL DES POIDS ET MESURES 2018 METROLOGIA -BERLIN- Vol.55 No.4

<P>By using a simple model to relate the electromotive force drift rate of Pt–Rh thermoelements to d<I>S</I>/d<I>c</I>, i.e. the sensitivity of the Seebeck coefficient, <I>S</I>, to rhodium mass fraction, <I>c</I>, the composition of the optimal pair of Pt–Rh wires that minimizes thermoelectric drift can be determined. The model has been applied to four multi-wire thermocouples each comprising 5 or 7 Pt–Rh wires of different composition. Two thermocouples were exposed to a temperature of around 1324 °C, one thermocouple to around 1492 °C, i.e. the melting points of the Co–C and Pd–C high temperature fixed points, respectively, and one thermocouple to a series of temperatures between 1315 °C and 1450 °C. The duration of exposure at each temperature was several thousand hours. By performing repeated calibrations <I>in situ</I> with the appropriate fixed point during the high temperature exposure, the drift performance has been quantified with high accuracy, entirely free from errors associated with thermoelectric homogeneity. By combining these results it is concluded that the Pt-40%Rh versus Pt-6%Rh is the most stable at the temperatures investigated. A preliminary reference function was determined and is presented.</P>

Negotiating a way in: Conducting narrative inquiry with young children

M.P.Pearce,Yeom, Ji-Sook 건국대학교 중원인문연구소 2001 동화와 번역 Vol.1 No.-

본 연구에서는 이제까지의 유아교육연구가 유아들의 지식이나 경험에 대한 체험이야기(stories of lived experiences)에 관심을 기울여오지 않았음을 지적하면서, 유아를 대상으로 하는 교육 연구를 위한 하나의 의미 있는 방법으로서 질적 연구의 한 갈래인 내러티브 탐구(Narrative Inquiry)를 적용하는 과정을 기술한다. Pearce(1995)와 Yeom(1996)의 연구를 예로 들어 내러티브 탐구의 자료수집과정, 연구자의 역할, 관계의 전개, 윤리적인 이슈 등을 구체적으로 다룬다. 유아들과의 연구에 몰입하는 일이 무엇을 의미하는가에 대한 저자들의 숙고 및 탐색을 통해, 유아들의 경험을 드러내주고 그들의 목소리를 듣는 일이 중요함을 강조한다. 이를 위해 본 연구에서는 유아들에게 자신들의 이야기를 할 시간과 공간을 제공해 줄 것을 제안한다. 본 연구에서는 또한 대답을 제시해 줄 수는 없지만, 유아들과의 내러티브 탐구에서 고려해야 할 몇 가지 관심사에 대해 질문을 제기하고 논한다.

Introduction: Mobility and the Making of Memories

Lynne Pearce Academy of Mobility Humanities 2022 Mobility Humanities Vol.1 No.2

Mobility and memory articulate in numerous ways—and yet, until now, there has been no dedicated attempt to reflect upon the implications of this special relationship within the field of mobilities studies. My own work in the field—which straddles the disciplines of literary and cultural studies, sociology and cultural geography—suggests the reason for this lies primarily with the contemporaneity of the most influential mobilities scholarship to date. The research led by social scientists, in particular, has been preoccupied with analyses of the contemporary world in relation to the future rather than the past (including the definition of the new mobilities paradigm [“NMP”] itself by Sheller and Urry in 2006 [Sheller and Urry; Urry]). This is despite the fact that others working within the field, such as Colin Pooley (whose work is featured in this special issue), have long shown how the mobility tipping points of history echo and foreshadow those taking place today (e.g., Pooley; Pooley, Turnbull and Adams). While there is, of course, no necessary connection between historical research and the practice of personal and/or collective memory per se, an interest in thinking-backwards as well as thinking-forwards with respect to the operation of the mobilities paradigm is helpful. In this regard, the work of geographers and historians working within the mobilities field has been an especially important counterweight to the “futures-thinking” of the social scientists with innovative “retrospective” research on (for example): the mobilities of loss, grief and mourning (e.g., Maddrell, “Living with the Deceased” and “Mapping Grief”); family and social mobility (e.g., Holdsworth); and the legacies of Empire across a range of settings and applications (e.g., Clarsen; Coleborne, Insanity and “Consorting with ‘Others”’; Lambert and Merriman). Whether explicitly or implicitly, these subfields also engage with the issue of how we, as individuals and communities, access and remember the past through complex processes of memory and memorialisation

Applications of Computer Modeling and Simulation in Cartilage Tissue Engineering

Daniel Pearce,Sarah Fischer,Fatama Huda,Ali Vahdati 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.1

BACKGROUND: Advances in cartilage tissue engineering have demonstrated noteworthy potential for developing cartilage for implantation onto sites impacted by joint degeneration and injury. To supplement resource-intensive in vivo and in vitro studies required for cartilage tissue engineering, computational models and simulations can assist in enhancing experimental design. METHODS: Research articles pertinent to cartilage tissue engineering and computer modeling were identified, reviewed, and summarized. Various applications of computer modeling for cartilage tissue engineering are highlighted, limitations of in silico modeling are addressed, and suggestions for future work are enumerated. RESULTS: Computational modeling can help better characterize shear stresses generated by bioreactor fluid flow, refine scaffold geometry, customize the mechanical properties of engineered cartilage tissue, and model rates of cell growth and dynamics. Thus, results from in silico studies can help resourcefully enhance in vitro and in vivo studies; however, the limitations of these studies, such as the underlying assumptions and simplifications applied in each model, should always be addressed and justified where applicable. In silico models should also seek validation and verification when possible. CONCLUSION: Future studies may adopt similar approaches to supplement in vitro trials and further investigate effects of mechanical stimulation on chondrocyte and stem cell dynamics. Additionally, as precision medicine, machine learning, and powerful open-source software become more popular and accessible, applications of multi-scale and multiphysics computational models in cartilage tissue engineering are expected to increase.

Essential elements of the iter pumping system for integrated commissioning and first operation

Robert PEARCE,Alexander ANTIPEKOV,Florin CHITU,Matthius DREMEL,Laim WORTH 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8