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Some results on total colorings of planar graphs
Jianfeng Hou,Guizhen Liu,Yongxun Xin,Mei Lan 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.3-4
Let G be a planar graph. It is proved that if G does not contain a k-cycle with a chord for some k ∈ {4, 5, 6}, then G is total-(△(G) + 2)-colorable.
SOME RESULTS ON TOTAL COLORINGS OF PLANAR GRAPHS
Hou, Jianfeng,Liu, Guizhen,Xin, Yongxun,Lan, Mei Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.3-4
Let G be a planar graph. It is proved that if G does not contain a k-cycle with a chord for some k ${\ni}$ {4,5,6}, then G is total-($\Delta(G)+2$)-colorable.
Zerong Cai,Xiaosheng He,Jianfeng Gong,Peng Du,Wenjian Meng,Wei Zhou,Jinbo Jiang,Bin Wu,Weitang Yuan,Qi Xue,Lianwen Yuan,Jinhai Wang,Jiandong Tai,Jie Liang,Weiming Zhu,Ping Lan,Xiaojian Wu 대한장연구학회 2023 Intestinal Research Vol.21 No.2
Background/Aims: The aim of this study was to analyze the chronological changes in postoperative complications in surgical ulcerative colitis patients over the past decade in China and to investigate the potential parameters that contributed to the changes. Methods: Ulcerative colitis patients who underwent surgery during 2008–2017 were retrospectively enrolled from 13 hospitals in China. Postoperative complications were compared among different operation years. Risk factors for complications were identified by logistic regression analysis. Results: A total of 446 surgical ulcerative colitis patients were analyzed. Fewer short-term complications (24.8% vs. 41.0%, P=0.001) and more laparoscopic surgeries (66.4% vs. 25.0%, P<0.001) were found among patients who received surgery during 2014–2017 than 2008–2013. Logistic regression suggested that independent protective factors against short-term complications were a higher preoperative body mass index (odds ratio [OR], 0.870; 95% confidence interval [CI], 0.785–0.964; P=0.008), laparoscopic surgery (OR, 0.391; 95% CI, 0.217–0.705; P=0.002) and elective surgery (OR, 0.213; 95% CI, 0.067–0.675; P=0.009). The chronological decrease in short-term complications was associated with an increase in laparoscopic surgery. Conclusions: Our data revealed a downward trend of short-term postoperative complications among surgical ulcerative colitis patients in China during the past decade, which may be due to the promotion of minimally invasive techniques among Chinese surgeons.
Dongwei Yuan,Li Qing,Lu Xing,Lan Jianfeng,Qiu Zhidong,Wang Xuehong,Wang Junnan,Zheng Xiaojiao,Chen Sifan,Zhang Chong,Jin Junfei 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury. A functional study confirmed that CERK and C1P attenuate hepatic injury both in vitro and in vivo through antioxidant effects. Mechanistic studies have shown that CERK and C1P positively regulate the protein expression of NRF2, which is a crucial protein that helps maintain redox homeostasis. Furthermore, our results indicated that C1P disrupted the interaction between NRF2 and KEAP1 by competitively binding to KEAP1, which allowed for the nuclear translocation of NRF2. In addition, pull-down assays and molecular docking analyses revealed that C1P binds to the DGR domain of KEAP1, which allows it to maintain its interaction with NRF2. Importantly, these findings were verified in human primary hepatocytes and a mouse model of hepatic ischemia‒reperfusion injury. Taken together, our findings demonstrated that CERK-mediated C1P metabolism attenuates acute liver injury via the binding of C1P to the DGR domain of KEAP1 and subsequently the release and nuclear translocation of NRF2, which activates the transcription of cytoprotective and antioxidant genes. Our study suggested that the upregulation of CERK and C1P expression may serve as a potential antioxidant strategy to alleviate acute liver injury.